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公开(公告)号：US20180128727A1
公开(公告)日：2018-05-10
申请号：US15569730
申请日：2016-04-28
IPC分类号： G01N15/06 , G01N27/327 , C12Q1/00
CPC分类号： G01N15/0656 , C12Q1/005 , C12Q1/006 , G01N27/327 , G01N27/3272
摘要： An electrochemical test device for determining a concentration of one or more analytes in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including two or more working electrodes, each working electrode for determining the concentration of a corresponding analyte, and sensing chemistry for each working electrode, wherein the sensing chemistry for a first of the two or more working electrodes comprises a diaphorase, an electron transfer agent, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase, wherein at least some of the diaphorase for the first working electrode is disposed in a diaphorase-containing layer which extends over the first working electrode and at least a second of the two or more working electrodes.
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公开(公告)号：US20170336339A1
公开(公告)日：2017-11-23
申请号：US15523220
申请日：2015-10-29
发明人： Marco Cardosi , Stephen Blythe
IPC分类号： G01N27/327 , A61B5/145 , A61B10/00 , G01N27/30 , A61B5/1477 , A61B5/157 , G01N33/487 , C12Q1/00
CPC分类号： G01N27/3274 , A61B5/1451 , A61B5/14517 , A61B5/1477 , A61B5/157 , A61B10/0051 , A61B10/0064 , A61B10/007 , A61B2010/0067 , A61B2010/008 , A61B2010/0087 , A61B2562/0295 , C12Q1/001 , C12Q1/006 , G01N27/301 , G01N33/48707
摘要： A method of using an electrochemical device includes at least first and second electrodes; a chamber for receiving a fluid sample and defining a volume partially bounded by a first portion of the first electrode and a second portion of the second electrode, the first portion having a first characteristic for influencing an electrochemical reaction at the first portion, the second portion having a second characteristic for influencing an electrochemical reaction at the second portion, the first and second characteristics having a predetermined relationship. The method also includes receiving a fluid sample in the chamber; measuring first and second electrical outputs at least one of the first and second electrodes; and determining whether the first and second electrical outputs are related according to the predetermined relationship.
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公开(公告)号：US10788442B2
公开(公告)日：2020-09-29
申请号：US15569742
申请日：2016-04-27
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/32 , C12Q1/26 , G01N35/00
摘要： An electrochemical test device for use in determining a concentration of each of a first analyte and a second analyte in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including a first working electrode having sensing chemistry for the first analyte and a second working electrode having sensing chemistry for the second analyte, wherein the first analyte is lactate and the sensing chemistry for the lactate comprises lactate oxidase and an electron transfer agent, and wherein the sensing chemistry for the second analyte comprises a diaphorase, an electron transfer agent, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase.
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公开(公告)号：US20180143155A1
公开(公告)日：2018-05-24
申请号：US15569742
申请日：2016-04-28
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/32
CPC分类号： G01N27/3272 , C12Q1/004 , C12Q1/26 , C12Q1/32 , G01N27/3271 , G01N2035/00118
摘要： An electrochemical test device for use in determining a concentration of each of a first analyte and a second analyte in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including a first working electrode having sensing chemistry for the first analyte and a second working electrode having sensing chemistry for the second analyte, wherein the first analyte is lactate and the sensing chemistry for the lactate comprises lactate oxidase and an electron transfer agent, and wherein the sensing chemistry for the second analyte comprises a diaphorase, an electron transfer agent, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase.
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公开(公告)号：US20180128766A1
公开(公告)日：2018-05-10
申请号：US15569841
申请日：2016-04-28
发明人： Marco Cardosi , Stephanie Kirkwood
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/32
CPC分类号： G01N27/3272 , C12Q1/004 , C12Q1/32 , G01N27/3273
摘要： An electrochemical test device for determining a concentration of an analyte in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including a working electrode for the analyte and sensing chemistry for the working electrode, wherein the sensing chemistry comprises a diaphorase, an electron transfer agent having a standard redox potential in the range of −0.52 to 0.18 V, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase.
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公开(公告)号：US10371617B2
公开(公告)日：2019-08-06
申请号：US15569730
申请日：2016-04-28
IPC分类号： G01N15/06 , G01N27/327 , C12Q1/00
摘要： An electrochemical test device for determining a concentration of one or more analytes in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including two or more working electrodes, each working electrode for determining the concentration of a corresponding analyte, and sensing chemistry for each working electrode, wherein the sensing chemistry for a first of the two or more working electrodes comprises a diaphorase, an electron transfer agent, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase, wherein at least some of the diaphorase for the first working electrode is disposed in a diaphorase-containing layer which extends over the first working electrode and at least a second of the two or more working electrodes.
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公开(公告)号：US20180128764A1
公开(公告)日：2018-05-10
申请号：US15569734
申请日：2016-04-28
发明人： Marco Cardosi , Stephanie Kirkwood
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/327 , C12Q1/004 , C12Q1/006 , C12Q1/32 , G01N27/3272
摘要： An electrochemical test device for determining a concentration of an analyte in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including a working electrode for the analyte and sensing chemistry for the working electrode, wherein the sensing chemistry is disposed on the working electrode in at least one layer, each layer comprising a diaphorase, an electron transfer agent having a standard redox potential in the range of −0.52 to 0.18 V, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase.
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公开(公告)号：US20180105856A1
公开(公告)日：2018-04-19
申请号：US15569901
申请日：2016-04-28
发明人： Marco Cardosi , Stephanie Kirkwood
IPC分类号： C12Q1/00 , G01N27/327 , A61B5/145 , C07F15/00
CPC分类号： C12Q1/004 , A61B5/14532 , C07F15/0053 , C12Q1/006 , G01N27/3272 , G01N2333/904
摘要： A composition is provided. The composition comprises an enzyme and a ruthenium- or osmium-based electron transfer agent, wherein the ruthenium- or osmium-based electron transfer agent is a complex [M(A)x(B)y] (X)n wherein M is ruthenium or osmium; A is an amine ligand; each B is a ligand different to A; x is an integer selected from 1 to 5; y is an integer selected from 1 to 5; x+y is 6 or 8; n is an integer selected from 1 to 6; and X is any suitable counterion.
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