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公开(公告)号：US20210347890A1
公开(公告)日：2021-11-11
申请号：US17305966
申请日：2021-07-19
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , UNIVERSITE PARIS 13 - PARIS NORD , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
摘要： Disclosed is CD31shed for use as a molecular imaging target in the molecular imaging of an inflammatory condition. Administering the radiolabeled peptide P8RI as CD31shed ligand in different rat models of inflammation indeed showed that CD31shed is present on activated cells in a quantity allowing a detectable signal, whereas the noise signal corresponding to CD31shed present on activated circulating cells and on other organs or cells not involved in inflammation was little. Also disclosed is a labeled CD31shed ligand and the use thereof as a molecular imaging agent in the molecular imaging of an inflammatory condition. The molecular imaging of inflammatory sites particularly allows determining whether a subject suffers from or is at risk of having an inflammatory condition or is at risk of recurrence of an inflammatory condition after an anti-inflammatory treatment.
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公开(公告)号：US20190092858A1
公开(公告)日：2019-03-28
申请号：US16098488
申请日：2017-05-03
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ PARIS DIDEROT - PARIS 7 , UNIVERSITE PARIS 13 - PARIS NORD , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , INSTITUT PASTEUR
摘要： Disclosed is CD31shed for use as a molecular imaging target in the molecular imaging of an inflammatory condition. Administering the radiolabeled peptide P8RI as CD31shed ligand in different rat models of inflammation indeed showed that CD31shed is present on activated cells in a quantity allowing a detectable signal, whereas the noise signal corresponding to CD31shed present on activated circulating cells and on other organs or cells not involved in inflammation was little. Also disclosed is a labeled CD31shed ligand and the use thereof as a molecular imaging agent in the molecular imaging of an inflammatory condition. The molecular imaging of inflammatory sites particularly allows determining whether a subject suffers from or is at risk of having an inflammatory condition or is at risk of recurrence of an inflammatory condition after an anti-inflammatory treatment.
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3.发明申请公开(公告)号：US20200165329A1
公开(公告)日：2020-05-28
申请号：US16700788
申请日：2019-12-02
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
摘要： The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
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4.发明申请CAMELID SINGLE-DOMAIN ANTIBODY DIRECTED AGAINST AMYLOID BETA AND METHODS FOR PRODUCING CONJUGATES THEREOF 有权针对AMYLOID BETA的CAMELID单抗体抗体及其生产方法公开(公告)号：US20160347831A1
公开(公告)日：2016-12-01
申请号：US15035582
申请日：2014-11-13
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6843 , A61K49/0058 , A61K49/108 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/22 , C07K2317/51 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387 , G01N2800/52
摘要： The present invention relates to variable domain of a camelid heavy-chain antibodies directed to amyloid β and conjugates thereof. The present invention also relates to the use of these antibody conjugates for treating or diagnosing disorders mediated by amyloid β deposits.
摘要翻译： 本发明涉及针对淀粉样蛋白β的骆驼重链抗体及其缀合物的可变结构域。 本发明还涉及这些抗体缀合物用于治疗或诊断由淀粉样蛋白β沉积物介导的病症的用途。
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公开(公告)号：US20230046953A1
公开(公告)日：2023-02-16
申请号：US17938865
申请日：2022-10-07
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (NRA) , THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
发明人： John P. BANNANTINE , Gilles ETIENNE , Sylvie BAY , Franck BIET
摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map)S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
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6.发明申请公开(公告)号：US20200024307A1
公开(公告)日：2020-01-23
申请号：US16470962
申请日：2017-12-20
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) , THE UNITED STATES OF AMERICA, AS REPREESENTED BY THE SECRETARY, AGRICULTURE
发明人： John P. BANNANTINE , Gilles ETIENNE , Sylvie BAY , Franck BIET
摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
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7.发明公开公开(公告)号：US20240270790A1
公开(公告)日：2024-08-15
申请号：US18606817
申请日：2024-03-15
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE L'ALIMENTATION ET L'ENVIRONNEMENT , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
发明人： John P. BANNANTINE , Gilles ETIENNE , Sylvie BAY , Franck BIET
CPC分类号： C07K5/0812 , A61K39/04 , A61K47/542 , A61K47/60 , C07K7/06 , C12Q1/689 , G01N33/5695 , G01N2333/5428 , G01N2333/57 , G01N2469/20 , G01N2800/26
摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO: 1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
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8.发明申请CAMELID SINGLE-DOMAIN ANTIBODY DIRECTED AGAINST PHOSPHORYLATED TAU PROTEINS AND METHODS FOR PRODUCING CONJUGATES THEREOF 审中-公开针对磷酸化TAU蛋白的CAMELID单抗体抗体及其生产方法公开(公告)号：US20170058022A1
公开(公告)日：2017-03-02
申请号：US15114324
申请日：2015-01-28
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES AL TERNATIVES , CENTRE NATION DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
CPC分类号： C07K16/18 , A61K49/0041 , A61K49/0058 , A61K49/16 , A61K51/10 , C07K2317/22 , C07K2317/34 , C07K2317/569 , G01N33/6896 , G01N2333/47 , G01N2440/14 , G01N2800/2821
摘要： The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
摘要翻译： 本发明涉及针对磷酸化tau蛋白及其缀合物的骆驼重链抗体的可变结构域。 本发明还涉及这些结构域或缀合物用于治疗或诊断由神经原纤维缠结，神经纤维丝或营养不良神经突诸如tau蛋白病介导的病症的用途。
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公开(公告)号：US20160355575A1
公开(公告)日：2016-12-08
申请号：US15035602
申请日：2014-11-13
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Pierre LAFAYE , Sylvie BAY , Benoit DELATOUR , Marc DHENAIN , Charles DUYCKAERTS , Tengfei LI , Matthias VANDESQUILLE , Christian CZECH , Fiona GRUENINGER
摘要： The present invention relates to an oligopeptide and conjugates thereof. The present invention also relates to the use of these oligopeptide conjugates for treating or diagnosing disorders mediated by amyloid β deposits. Finally, the present invention also relates to a coupling method for obtaining oligopeptide coupled with a substance of interest (functional conjugates).
摘要翻译： 本发明涉及寡肽及其缀合物。 本发明还涉及这些寡肽缀合物用于治疗或诊断由淀粉样蛋白β沉积物介导的病症的用途。 最后，本发明还涉及用于获得与感兴趣物质（功能性共轭物）偶联的寡肽的偶联方法。
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