公开(公告)号：US20240398893A1

公开(公告)日：2024-12-05

申请号：US18756768

申请日：2024-06-27

Applicant: Institute of Microbiology, Chinese Academy of Sciences ,  Hybio Pharmaceutical Co., Ltd.

Inventor： Fu GAO ,  Shaogui ZENG ,  Qihui WANG ,  Yangming TANG ,  Jiantao CHEN ,  Lili WU ,  Anqi ZHENG

IPC: A61K38/16 ,  A61K47/54 ,  A61K47/60 ,  A61P31/14

Abstract: The invention relates to an anti-coronavirus polypeptide as well as derivatives and application thereof, provides the anti-coronavirus polypeptide, and provides cholesterol-containing derivatives of the polypeptide on the basis of the anti-coronavirus polypeptide. Particularly, the original strain and the variant strain of the SARS-COV-2 have an unexpected inhibition effect, can be used for preparing medicines or vaccines for preventing or treating the new coronavirus, and have great prevention or treatment potential.

公开(公告)号：US20240173395A1

公开(公告)日：2024-05-30

申请号：US17775094

申请日：2020-11-09

Applicant: Institute of Microbiology, Chinese Academy of Sciences

Inventor： Fu GAO ,  Lianpan DAI ,  Jinghua YAN ,  Kun XU ,  Yuxuan HAN ,  Qihui WANG ,  Qingrui HUANG ,  Jinhe LI

IPC: A61K39/12 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/5254 ,  A61K2039/53 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2770/24122 ,  C12N2770/24134

Abstract: Provided in the present disclosure are a Zika/dengue vaccine and its application thereof. The present disclosure introduces a mutation into the E-protein FL fusion region of the Zika virus or dengue virus. Antigens with said mutations are unable to bind to antibodies that causes ADE. After immunization with the vaccine of the present disclosure acquired from the said antigens, production of FL epitope-induced antibodies can be prevented, thereby reducing or eliminating the ADE effect.

公开(公告)号：US20240262894A1

公开(公告)日：2024-08-08

申请号：US18566962

申请日：2022-06-13

Applicant: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES

Inventor： Fu GAO ,  Lianpan DAI ,  Jian SONG ,  Senyu XU ,  Qihui WANG

IPC: C07K16/10 ,  A61K39/00 ,  G01N33/569 ,  G01N33/577

CPC classification number: C07K16/1027 ,  G01N33/56983 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/135 ,  G01N2469/10

Abstract: Provided in the present disclosure is an antibody or an antigen-binding fragment thereof that binds to the respiratory syncytial virus F protein. Further provided in the present disclosure is the use of the antibody or the antigen-binding fragment thereof in the preparation of a drug for the treatment and/or prevention of RSV infections.