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公开(公告)号：US20050119320A1
公开(公告)日：2005-06-02
申请号：US10504259
申请日：2003-02-27
申请人： Ian Bruce , Peter Finan , Catherine Leblanc , Clive McCarthy , Lewis Whitehead , Nicola Press , Graham Bloomfield , Judy Hayler , Louise Kirman , Mrinalini Oza , Lena Shukla
发明人： Ian Bruce , Peter Finan , Catherine Leblanc , Clive McCarthy , Lewis Whitehead , Nicola Press , Graham Bloomfield , Judy Hayler , Louise Kirman , Mrinalini Oza , Lena Shukla
IPC分类号： C07D277/20 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P1/04 , A61P3/04 , A61P3/10 , A61P7/08 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/48 , C07D417/04 , C07D417/12 , C07D417/02 , C07D277/18
CPC分类号： C07D277/40 , C07D277/46 , C07D277/48 , C07D417/04 , C07D417/12
摘要： Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中R 1，R 2，R 3，R 4， 和R 5具有如说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US07687637B2
公开(公告)日：2010-03-30
申请号：US10504259
申请日：2003-02-27
申请人： Ian Bruce , Peter Finan , Catherine Leblanc , Clive McCarthy , Lewis Whitehead , Nicola Press , Graham Charles Bloomfield , Judy Hayler , Louise Kirman , Mrinalini Sachin Oza , Lena Shukla
发明人： Ian Bruce , Peter Finan , Catherine Leblanc , Clive McCarthy , Lewis Whitehead , Nicola Press , Graham Charles Bloomfield , Judy Hayler , Louise Kirman , Mrinalini Sachin Oza , Lena Shukla
IPC分类号： A61K31/426 , C07D277/46
CPC分类号： C07D277/40 , C07D277/46 , C07D277/48 , C07D417/04 , C07D417/12
摘要： Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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3.发明申请公开(公告)号：US20060148822A1
公开(公告)日：2006-07-06
申请号：US10547691
申请日：2004-03-05
申请人： Graham Bloomfield , Ian Bruce , Catherine Leblanc , Mrinalini Oza , Lewis Whithead , Bernard Cuenoud , Thomas Keller , Louise Kirman , Clive McCarthy , Gaynor Woodward
发明人： Graham Bloomfield , Ian Bruce , Catherine Leblanc , Mrinalini Oza , Lewis Whithead , Bernard Cuenoud , Thomas Keller , Louise Kirman , Clive McCarthy , Gaynor Woodward
IPC分类号： C07D417/02 , A61K31/497 , A61K31/4439
CPC分类号： C07D417/14 , C07D277/42 , C07D417/12
摘要： Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中R 1，R 2，R 3，R 4， 和R 5具有说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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4.发明授权公开(公告)号：US08017608B2
公开(公告)日：2011-09-13
申请号：US10547691
申请日：2004-03-05
申请人： Graham Charles Bloomfield , Ian Bruce , Catherine Leblanc , Mrinalini Sachin Oza , Lewis Whithead , Bernard Cuenoud , Thomas Hugo Keller , Louise Kirman , Clive McCarthy , Gaynor Elizabeth Woodward
发明人： Graham Charles Bloomfield , Ian Bruce , Catherine Leblanc , Mrinalini Sachin Oza , Lewis Whithead , Bernard Cuenoud , Thomas Hugo Keller , Louise Kirman , Clive McCarthy , Gaynor Elizabeth Woodward
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4523 , A61K31/41 , A61K31/426 , A61K31/427 , C07D413/02 , C07D401/02 , C07D403/02 , C07D285/12
CPC分类号： C07D417/14 , C07D277/42 , C07D417/12
摘要： Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中指出的含义，可用于治疗由磷脂酰肌醇3-激酶介导的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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5.发明申请Pyrazole Derivatives for Treating Condit Ions Mediated by Activation of the Adeno Sine A2B or A3 Receptor 审中-公开用于治疗由Adeno Sine A2B或A3受体激活介导的杂化子的吡唑衍生物公开(公告)号：US20070225335A1
公开(公告)日：2007-09-27
申请号：US11573273
申请日：2005-08-10
IPC分类号： A61K31/415 , A61K31/4439 , C07D231/10 , C07D401/00
CPC分类号： C07D231/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04
摘要： Compounds of formula I in free or salt form, wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating a condition mediated by activation of the adenosine A2b receptor or the adenosine A3 receptor, particularly an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中R 1，R 2，R 3和R 4， 具有说明书中所示的含义，可用于治疗腺苷A2b受体或腺苷A3受体的活化介导的病症，特别是炎性或阻塞性气道疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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6.发明申请5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开5-苯基-4-甲基 - 噻唑-2-基胺衍生物作为磷酸胆碱酯酶3激酶（PI3）的抑制剂治疗炎症性疾病公开(公告)号：US20110124693A1
公开(公告)日：2011-05-26
申请号：US13020211
申请日：2011-02-03
申请人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
发明人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
IPC分类号： A61K31/427 , A61P11/00 , A61P35/00 , A61P11/06 , A61P29/00 , A61P9/10 , A61P3/10 , A61P3/04 , A61P9/00 , A61P37/08 , A61P17/06
CPC分类号： C07D451/04 , C07D277/48 , C07D417/12 , C07D471/04
摘要： Compounds of Formula I: in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 式I化合物：游离或盐形式，其中R a，R b，R 2，R 3，R 4和R 5具有说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的病症。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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7.发明授权5-phenyl-4-methyl-thiazol-2-yl-amine derivatives as inhibitors of phosphatidylin ositol 3 kinase enzymes (PI13) for treatment of inflammatory diseases 失效5-苯基-4-甲基 - 噻唑-2-基 - 胺衍生物作为用于治疗炎症性疾病的磷脂酰骨甙硫蛋白3激酶（PI13）的抑制剂公开(公告)号：US07902375B2
公开(公告)日：2011-03-08
申请号：US10568053
申请日：2004-08-27
申请人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
发明人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D451/04 , C07D277/48 , C07D417/12 , C07D471/04
摘要： in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 其中R a，R b，R 2，R 3，R 4和R 5具有说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的病症。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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8.发明申请5-Phenyl-4-Methyl-Thiazol-2-Yl-Amine Derivatives as Inhibitors of Phosphatidylin Ositol 3 Kinase Enzymes (PI13) For Treatment of Inflammatory Diseases 失效5-苯基-4-甲基 - 噻唑-2-基胺衍生物作为磷脂酰肌醇蛋白的抑制剂Ositol 3激酶（PI13）用于治疗炎性疾病公开(公告)号：US20080280871A1
公开(公告)日：2008-11-13
申请号：US10568053
申请日：2004-08-27
申请人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
发明人： Graham Charles Bloomfield , Ian Bruce , Judy Fox Hayler , Catherine Leblanc , Darren Mark Le Grand , Clive McCarthy
IPC分类号： A61K31/426 , C07D277/42 , C07D417/12 , A61K31/5377 , A61P17/06 , A61P11/00
CPC分类号： C07D451/04 , C07D277/48 , C07D417/12 , C07D471/04
摘要： in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 游离或盐形式，其中R a，R b，R b，R 3，R 3，R SUP > 4和R 5具有说明书中所示的含义，可用于治疗由磷脂酰肌醇3-激酶介导的病症。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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公开(公告)号：US20090298824A1
公开(公告)日：2009-12-03
申请号：US10585265
申请日：2005-01-20
申请人： Neil J. Press , David Porter , Catherine Leblanc , Clive McCarthy , Nicolas Soldermann , Lyndon N. Brown
发明人： Neil J. Press , David Porter , Catherine Leblanc , Clive McCarthy , Nicolas Soldermann , Lyndon N. Brown
IPC分类号： A61K31/5377 , C07D235/30 , A61K31/4184 , C07D413/12 , C07D487/04 , A61P11/00
CPC分类号： C07D263/58 , C07D235/30 , C07D487/04
摘要： Compounds of formula I in free or salt form, where Y, R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the CXCR2 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
摘要翻译： 游离或盐形式的式I化合物，其中Y，R 1，R 2，R 3，R 4和R 5具有说明书中所示的含义，可用于治疗由CXCR2受体介导的病症。 还描述了含有化合物的药物组合物和制备该化合物的方法。
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公开(公告)号：US20170066766A1
公开(公告)日：2017-03-09
申请号：US15357195
申请日：2016-11-21
申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao
IPC分类号： C07D471/04 , C07D519/00 , C07D498/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
摘要翻译： 制备所述化合物的方法及其治疗用途。 本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。
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