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    Liquid feeder for automatic culture apparatus
    4.
    发明授权
    Liquid feeder for automatic culture apparatus 失效
    自动培养装置的液体给料机

    公开(公告)号：US4234023A

    公开(公告)日：1980-11-18

    申请号：US973117

    申请日：1978-12-26

    申请人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    发明人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    IPC分类号： C12M1/26 ,  G01N1/00 ,  B65B3/04

    CPC分类号： C12M33/04 ,  Y10T74/1424

    摘要： A liquid feeder comprises a liquid suction and delivery pump which withdraws a liquid such as a culture solution, buffer solution, enzyme solution or the like which is retained in a liquid storage container as refrigerated or at a reduced temperature and delivers it through a flexible tube for injection into a culture vessel located within an incubator. The tube is inserted into an inner pipe and is sealingly secured thereto. The inner pipe is detachably and hermetically mounted in an outer pipe which extends through and is secured to a wall forming an environment isolating layer of the incubator. An eccentric crankpin which is driven by a motor is connected through a link with another crankpin having a greater eccentricity, the latter crankpin being driven for rotation to cause a reciprocatory rotating motion of a driven shaft about its own axis through an angular extent of less than 180.degree.. The motion of the driven shaft is effective to selectively switch the discharge port of a pair of liquid supply tubes to a position over a single vessel. The motor also drives a cam which causes a vertical motion of a drive shaft which is also angularly driven by a cam groove, the drive shaft being effective to cause a three dimensional motion of the discharge port of a single liquid supply tube for injection into a pair of vessels.

    摘要翻译： 液体供给器包括一个液体抽吸和输送泵，其将诸如培养液，缓冲溶液，酶溶液等液体冷却或降低的温度保存在液体储存容器中并将其输送通过柔性管 用于注射到位于培养箱内的培养容器中。 将管插入内管并密封地固定在其上。 内管可拆卸地且气密地安装在外管中，该外管延伸穿过并固定到形成培养箱的环境隔离层的壁上。 由马达驱动的偏心曲柄销通过与具有较大偏心率的另一个曲柄销的连杆连接，后者的曲柄销被驱动以旋转，从而使从动轴围绕其自身轴线往复运动，角度范围小于 180度。 从动轴的运动有效地将一对液体供给管的排出口选择性地切换到单个容器上的位置。 电动机还驱动一个凸轮，该​​凸轮引起驱动轴的垂直运动，驱动轴也由凸轮槽角度地驱动，驱动轴有效地使单个供液管的排出口的三维运动注入到 一对船只。

    Liquid feeder for automatic culture apparatus
    6.
    发明授权
    Liquid feeder for automatic culture apparatus 失效
    自动培养装置的液体给料机

    公开(公告)号：US4179339A

    公开(公告)日：1979-12-18

    申请号：US876894

    申请日：1978-02-13

    申请人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    发明人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    IPC分类号： C12M1/26 ,  G01N1/00 ,  C12K1/10

    CPC分类号： C12M33/04 ,  Y10T74/1424

    摘要： A liquid feeder comprises a liquid suction and delivery pump which withdraws a liquid such as a culture solution, buffer solution, enzyme solution or the like which is retained in a liquid storage container as refrigerated or at a reduced temperature and delivers it through a flexible tube for injection into a culture vessel located within an incubator. The tube is inserted into an inner pipe and is sealingly secured thereto. The inner pipe is detachably and hermetically mounted in an outer pipe which extends through and is secured to a wall forming an environment isolating layer of the incubator. An eccentric crankpin which is driven by a motor is connected through a link with another crankpin having a greater eccentricity, the latter crankpin being driven for rotation to cause a reciprocatory rotating motion of a driven shaft about its own axis through an angular extent of less than 180.degree.. The motion of the driven shaft is effective to selectively switch the discharge port of a pair of liquid supply tubes to a position over a single vessel. The motor also drives a cam which causes a vertical motion of a drive shaft which is also angularly driven by a cam groove, the drive shaft being effective to cause a three dimensional motion of the discharge port of a single liquid supply tube for injection into a pair of vessels.

    摘要翻译： 液体供给器包括一个液体抽吸和输送泵，其将诸如培养液，缓冲溶液，酶溶液等液体冷却或降低的温度保存在液体储存容器中并将其输送通过柔性管 用于注射到位于培养箱内的培养容器中。 将管插入内管并密封地固定在其上。 内管可拆卸地且气密地安装在外管中，该外管延伸穿过并固定到形成培养箱的环境隔离层的壁上。 由马达驱动的偏心曲柄销通过与具有较大偏心率的另一个曲柄销的连杆连接，后者的曲柄销被驱动以旋转，从而使从动轴围绕其自身轴线往复运动，角度范围小于 180度。 从动轴的运动有效地将一对液体供给管的排出口选择性地切换到单个容器上的位置。 电动机还驱动一个凸轮，该​​凸轮引起驱动轴的垂直运动，驱动轴也由凸轮槽角度地驱动，驱动轴有效地使单个供液管的排出口的三维运动注入到 一对船只。

    Apparatus for liquid disposal and distribution in automatic culture system
    7.
    发明授权
    Apparatus for liquid disposal and distribution in automatic culture system 失效
    用于自动培养系统中液体处理和分配的装置

    公开(公告)号：US4210724A

    公开(公告)日：1980-07-01

    申请号：US888036

    申请日：1978-03-20

    申请人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    发明人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    IPC分类号： C12M1/32 ,  C12M1/26

    CPC分类号： C12M41/48 ,  C12M23/10 ,  C12M33/04

    摘要： An apparatus for liquid disposal and distribution in automatic culture system comprises a first turntable carrying a plurality of culture vessels disposed in an array on a common circle thereon, and a second turntable carrying a plurality of centrifuge tubes disposed in an array on a common circle thereof. The apparatus comprises a pipette holding arm which is disposed so that its free end is angularly movable between one of the culture vessels and one of the centrifuge tubes. The free end of the arm has attached thereto a tapered cylinder which detachably receives a pipette. A fixed displacement pump is connected with the cylinder, which is movable along the path of rotation, along which are disposed a pipette holder, a pipette remover and a liquid disposal pot. The apparatus also comprises a rotary and elevating mechanism associated with the arm. In this manner, the apparatus is capable of transferring a specimen being cultured from a culture vessel to a centrifuge tube, distributing grown cells from the tube into culture vessels and disposing unnecessary liquid. In addition, the apparatus is capable of agitating a culturing solution within the culture vessel to render the cells into suspension.

    摘要翻译： 一种用于自动培养系统中的液体处理和分配的装置包括：第一转盘，其承载以阵列布置在其上的公共圆上的多个培养容器;以及第二转台，其携带多个在其公共圆上阵列设置的离心管 。 该装置包括移液管保持臂，其设置成使得其自由端在一个培养容器和一个离心管之间成角度地移动。 臂的自由端附接有可拆卸地接收移液管的锥形圆筒。 固定容积泵与气缸连接，该气缸可沿旋转路径移动，沿着该移动路径设置移液管支架，吸移管移除器和液体处理罐。 该装置还包括与臂相关联的旋转和升降机构。 以这种方式，该装置能够将从培养容器中培养的样品转移到离心管中，将生长的细胞从管分配到培养容器中并处理不需要的液体。 此外，该装置能够搅拌培养容器内的培养液以使细胞悬浮。

    Apparatus for handling centrifuge tubes in automatic culture system
    8.
    发明授权
    Apparatus for handling centrifuge tubes in automatic culture system 失效
    用于在自动培养系统中处理离心管的装置

    公开(公告)号：US4208484A

    公开(公告)日：1980-06-17

    申请号：US885599

    申请日：1978-03-13

    申请人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    发明人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    IPC分类号： B04B5/04 ,  C12M3/00 ,  C12M1/00

    CPC分类号： C12M33/10 ,  B04B5/0421 ,  B04B2011/046

    摘要： An apparatus for handling a centrifuge tube in an automatic culture system includes a centrifuge, above which is disposed a centrifuge tube carrying turntable which is intermittently driven through a given angular increment. Disposed at an equal spacing on and around the periphery of the turntable are centrifuge tube holder mechanisms each carrying a centrifuge tube holder. Also disposed in surrounding relationship with the turntable and at given positions where the latter comes to a stop are a plurality of processing stations including a centrifuge delivery unit which automatically delivers a centrifuge tube into the holder, a liquid disposal unit for disposing unnecessary culture solution from the centrifuge tube which has been subjected to the action of the centrifuge, a discharge unit for discharging a used centrifuge tube subsequent to the completion of the culturing operation, a transfer unit for transferring a centrifuge tube between the centrifuge holder mechanism and a holder receiver located within the centrifuge. As the turntable is incremently driven, the centrifuge tube is successively conveyed through a culture treatment and a centrifuge tube processing position.

    摘要翻译： 用于在自动培养系统中处理离心管的装置包括离心机，其上设置有离心管，承载转盘，其间歇地通过给定的角度增量驱动。 在离合器托架机构中，转盘周边等间隔设置有离心管支架机构，每个离心管支架机构都带有离心管支架。 还设置在与转台的周围关系中以及在后者停止的给定位置处的多个处理站包括离心机输送单元，其将离心管自动输送到保持器中，液体处理单元，用于将不必要的培养液从 已经经受离心机作用的离心管，用于在完成培养操作之后排出使用的离心管的排出单元，用于将离心机管转移到离心机保持器机构和位于 在离心机内。 随着转台逐渐驱动，离心管依次通过培养处理和离心管处理位置传送。

    Drive system for automatic culture apparatus
    9.
    发明授权
    Drive system for automatic culture apparatus 失效
    自动培养仪驱动系统

    公开(公告)号：US4160699A

    公开(公告)日：1979-07-10

    申请号：US847553

    申请日：1977-11-01

    申请人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    发明人： Shinroku Sogi ,  Makoto Yoshinaga ,  Toshio Shinohara ,  Takayuki Aihara ,  Ikuo Tawara

    IPC分类号： C12M3/00 ,  B01L3/00 ,  G01N35/00 ,  G01N35/04 ,  C12K1/10

    CPC分类号： G01N35/04 ,  G01N2035/00356 ,  G01N2035/042 ,  G01N35/025

    摘要： An automatic culture apparatus includes an airtight casing, a culture vessel platform, a culture observation platform and a separation/distribution work platform disposed in layered configuration with suitable vertical spacings between them. A drive system for the apparatus comprises an opening formed centrally in each of the platforms; a culture vessel carrier for conveying a culture vessel to each of the platforms through the openings; a transfer arm for loading and unloading a culture vessel on or from the carrier and any one of the platforms; a first drive mechanism for operating the carrier and the transfer arm; and a second drive mechanism for driving any one of the platforms. The second drive mechanism is mounted hermetically in the casing. By operating suitable drive mechanisms to actuate the various parts, a culture vessel may be automatically transferred and distributed on each of the platforms without causing contamination in a safe and efficient manner, for automatic growth of the medium being cultured under an optimum environment.

    摘要翻译： 一种自动培养装置，包括密封壳体，培养皿平台，培养观察平台和分层/分配工作平台，其分层结构具有合适的垂直间距。 该装置的驱动系统包括：在每个平台中央形成的开口; 用于通过开口将培养容器输送到每个平台的培养容器载体; 用于在载体和任何一个平台上装载和卸载培养容器的转移臂; 用于操作所述载体和所述传送臂的第一驱动机构; 以及用于驱动任何一个平台的第二驱动机构。 第二驱动机构气密地安装在壳体中。 通过操作合适的驱动机构来致动各种部件，培养容器可以自动转移和分布在每个平台上，而不会以安全和有效的方式引起污染，从而在最佳环境下培养的培养基的自动生长。