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公开(公告)号：US09981922B2
公开(公告)日：2018-05-29
申请号：US15043121
申请日：2016-02-12
IPC分类号： C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48
CPC分类号： C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , A61K2300/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US11773068B2
公开(公告)日：2023-10-03
申请号：US17481649
申请日：2021-09-22
IPC分类号： C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
CPC分类号： C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , C07B2200/05 , C07B2200/07 , C07B2200/13 , A61K31/397 , A61K2300/00 , A61K31/41 , A61K2300/00 , A61K31/4162 , A61K2300/00 , A61K31/4192 , A61K2300/00 , A61K31/4196 , A61K2300/00 , A61K31/435 , A61K2300/00 , A61K31/445 , A61K2300/00 , A61K31/454 , A61K2300/00 , A61K31/495 , A61K2300/00 , A61K31/496 , A61K2300/00 , A61K31/4995 , A61K2300/00 , A61K31/501 , A61K2300/00 , A61K31/506 , A61K2300/00 , A61K31/5377 , A61K2300/00 , A61K31/5383 , A61K2300/00 , A61K31/54 , A61K2300/00 , A61K31/541 , A61K2300/00 , A61K31/551 , A61K2300/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US11578059B2
公开(公告)日：2023-02-14
申请号：US17054126
申请日：2019-05-13
IPC分类号： A61K31/497 , C07D403/14 , A61K9/00 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D241/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D491/107
摘要： The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.
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公开(公告)号：US11230534B2
公开(公告)日：2022-01-25
申请号：US16672083
申请日：2019-11-01
IPC分类号： A61K31/397 , C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US10519118B2
公开(公告)日：2019-12-31
申请号：US15952073
申请日：2018-04-12
IPC分类号： C07D249/06 , A61K31/495 , A61K31/41 , C07D401/12 , C07D403/12 , C07D491/107 , C07D471/10 , C07D498/08 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , A61K31/4192 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D413/12 , A61K31/5377 , A61K31/5383 , A61K31/435 , C07D401/04 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US11932629B2
公开(公告)日：2024-03-19
申请号：US18066667
申请日：2022-12-15
IPC分类号： C07D403/14 , A61K9/00 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D241/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D491/107
CPC分类号： C07D403/14 , A61K9/0053 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D241/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D491/107
摘要： The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.
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公开(公告)号：US20160237043A1
公开(公告)日：2016-08-18
申请号：US15043121
申请日：2016-02-12
IPC分类号： C07D249/06 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , C07C309/30
CPC分类号： C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , A61K2300/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
摘要翻译： 本文公开了新的化合物和组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制KDM1A的方法，增加γ珠蛋白基因表达的方法以及诱导人或动物受试者中癌细胞分化的方法，用于治疗诸如急性骨髓性白血病等疾病。
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