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1.ALKYNYLPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME 失效
标题翻译: 亚苄基嘧啶及其盐,其包含其的药物组合物,其制备方法及其用途公开(公告)号:US20090099219A1
公开(公告)日:2009-04-16
申请号:US12142279
申请日:2008-06-19
申请人: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Heinz Thierauch , Philip Lienau , Ulf Boemer
发明人: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Heinz Thierauch , Philip Lienau , Ulf Boemer
IPC分类号: A61K31/505 , A61P9/00 , A61P35/00 , A61P29/00 , A61P9/10 , C07D239/48 , C07D403/10 , C07D401/10 , A61K31/506
CPC分类号: C07D239/48 , C07D401/06 , C07D403/06
摘要: The invention relates to alkynylpyrimidines according to the general formula (I): in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, and salts, N-oxides, metabolites, solvates, tautomers and prodrugs thereof, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
摘要翻译: 本发明涉及根据通式(I)的炔基嘧啶:其中A,R 1,R 2,R 3,R 4,R 5和R 6如权利要求中所定义,以及盐,N-氧化物,代谢物,溶剂合物,互变异构体和 包含所述炔基嘧啶的药物组合物,制备所述炔基嘧啶的方法,及其制备用于治疗失调血管生长疾病的药物组合物或伴有血管生成失调的疾病的用途,其中, 化合物有效地干扰Tie2和VEGFR2信号。
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公开(公告)号:US08524724B2
公开(公告)日:2013-09-03
申请号:US12142279
申请日:2008-06-19
申请人: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer
发明人: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer
IPC分类号: A01N43/54 , A61K31/505 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D239/02
摘要: The invention relates to alkynylpyrimidines according to the general formula (I): in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, and salts, N-oxides, metabolites, solvates, tautomers and prodrugs thereof, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
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3.Alkynylpyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same 失效
标题翻译: 炔基嘧啶及其盐,包含其的药物组合物,其制备方法及其用途公开(公告)号:US08642611B2
公开(公告)日:2014-02-04
申请号:US12142279
申请日:2008-06-19
申请人: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer
发明人: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer
IPC分类号: A01N43/54 , A61K31/505 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D239/02
CPC分类号: C07D239/48 , C07D401/06 , C07D403/06
摘要: The invention relates to alkynylpyrimidines according to the general formula (I): in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, and salts, N-oxides, metabolites, solvates, tautomers and prodrugs thereof, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
摘要翻译: 本发明涉及根据通式(I)的炔基嘧啶:其中A,R 1,R 2,R 3,R 4,R 5和R 6如权利要求中所定义,以及盐,N-氧化物,代谢物,溶剂合物,互变异构体和 包含所述炔基嘧啶的药物组合物,制备所述炔基嘧啶的方法,及其制备用于治疗失调血管生长疾病的药物组合物或伴有血管生成失调的疾病的用途,其中, 化合物有效地干扰Tie2和VEGFR2信号。
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4.Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs 有权
标题翻译: 磺酰亚胺取代的嘧啶,其制备方法和用途作为药物公开(公告)号:US07825128B2
公开(公告)日:2010-11-02
申请号:US11642961
申请日:2006-12-21
申请人: Ulrich Lücking , Duy Nguyen , Arne Von Bonin , Oliver Von Ahsen , Martin Krüger , Hans Briem , Georg Kettschau , Olaf Prien , Anne Mengel , Krolikiewicz Konrad , Ulf Boemer , Ulrich Bothe , Ingo Hartung
发明人: Ulrich Lücking , Duy Nguyen , Arne Von Bonin , Oliver Von Ahsen , Martin Krüger , Hans Briem , Georg Kettschau , Olaf Prien , Anne Mengel , Krolikiewicz Konrad , Ulf Boemer , Ulrich Bothe , Ingo Hartung
IPC分类号: C07D239/47 , C07D239/48 , C07D403/04 , C07D403/14 , C07D409/04 , C07D409/14 , C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04 , A61K31/505 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号: C07D239/28 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs.
摘要翻译: 本发明涉及通式I的亚磺酰亚胺取代嘧啶,其制备方法及其作为药物的用途。
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5.Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs 有权
标题翻译: 磺酰亚胺取代的嘧啶,其制备方法和用途作为药物公开(公告)号:US20070232632A1
公开(公告)日:2007-10-04
申请号:US11642961
申请日:2006-12-21
申请人: Ulrich Lucking , Duy Nguyen , Arne Von Bonin , Oliver Von Ahsen , Martin Kruger , Hans Briem , Georg Kettschau , Olaf Prien , Anne Mengel , Krolikiewicz Konrad , Ulf Boemer , Ulrich Bothe , Ingo Hartung
发明人: Ulrich Lucking , Duy Nguyen , Arne Von Bonin , Oliver Von Ahsen , Martin Kruger , Hans Briem , Georg Kettschau , Olaf Prien , Anne Mengel , Krolikiewicz Konrad , Ulf Boemer , Ulrich Bothe , Ingo Hartung
IPC分类号: A61K31/506 , C07D417/02
CPC分类号: C07D239/28 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs.
摘要翻译: 本发明涉及通式I的亚磺酰亚胺取代嘧啶,其制备方法及其作为药物的用途。
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公开(公告)号:US20060074084A1
公开(公告)日:2006-04-06
申请号:US11233533
申请日:2005-09-23
申请人: Duy Nguyen , Anne Mengel , Martin Fritsch , Gernor Langer , Ulf Boemer , Knut Eis , Bernd Menzenbach , Bernd Buchmann , Seock-Kyu Khim
发明人: Duy Nguyen , Anne Mengel , Martin Fritsch , Gernor Langer , Ulf Boemer , Knut Eis , Bernd Menzenbach , Bernd Buchmann , Seock-Kyu Khim
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/405 , C07D413/02 , C07D405/02 , C07D403/02
CPC分类号: C07D405/12 , C07D209/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D417/12
摘要: The invention relates to compounds of general formula I as well as their production and use as a medication.
摘要翻译: 本发明涉及通式I的化合物及其作为药物的生产和用途。
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7.Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 失效
标题翻译: 多取代四氢萘衍生物,其制备方法及其作为抗炎剂的用途公开(公告)号:US08097627B2
公开(公告)日:2012-01-17
申请号:US12642121
申请日:2009-12-18
申请人: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
发明人: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC分类号: A61K31/50 , A61K31/517 , A61K31/47 , C07D237/30 , C07D287/72 , C07D217/22 , C07D215/02
CPC分类号: C07D217/24 , A61K31/47 , A61K31/472 , A61K31/517 , C07C215/44 , C07C255/58 , C07C2602/10 , C07D209/34 , C07D209/46 , C07D213/74 , C07D215/04 , C07D215/22 , C07D215/227 , C07D215/38 , C07D215/48 , C07D215/58 , C07D231/56 , C07D237/32 , C07D239/74 , C07D239/76 , C07D277/64 , C07D307/88 , C07D317/70 , C07D405/12 , C07D471/04
摘要: The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式(I)的多取代四氢萘衍生物的制备方法及其作为抗炎剂的用途。
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8.Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs 审中-公开
标题翻译: 三环氨基醇,其合成方法和使用与抗炎药物相同公开(公告)号:US20060167025A1
公开(公告)日:2006-07-27
申请号:US11312655
申请日:2005-12-21
申请人: Markus Berger , Norbert Schmees , Heike Schaecke , Stefan Baurle , Hartmut Rehwinkel , Anne Mengel , Konrad Krolikiewicz , Danja Grossbach , David Voigtlaender
发明人: Markus Berger , Norbert Schmees , Heike Schaecke , Stefan Baurle , Hartmut Rehwinkel , Anne Mengel , Konrad Krolikiewicz , Danja Grossbach , David Voigtlaender
IPC分类号: A61K31/517 , A61K31/403 , A61K31/381 , A61K31/343
CPC分类号: C07D409/12 , C07D405/12
摘要: The invention relates to tricyclic amino alcohols of general formula (I) method for synthesis of same and use of same as anti-inflammatory agents.
摘要翻译: 本发明涉及通式(I)的合成方法的三环氨基醇及其与抗炎剂的用途。
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9.Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 审中-公开
标题翻译: 多取代四氢萘衍生物,其制备方法及其作为抗炎剂的用途公开(公告)号:US20050222154A1
公开(公告)日:2005-10-06
申请号:US10961375
申请日:2004-10-12
申请人: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
发明人: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC分类号: A61K31/498 , A61K31/502 , A61K31/517 , A61K31/538
CPC分类号: C07D217/24 , C07D215/227 , C07D237/32 , C07D239/74
摘要: The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式(I)的多取代四氢萘衍生物的制备方法及其作为抗炎剂的用途。
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10.Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents 失效
标题翻译: 四氢萘衍生物,其生产方法及其作为抗炎剂的用途公开(公告)号:US20050209324A1
公开(公告)日:2005-09-22
申请号:US10961406
申请日:2004-10-12
申请人: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
发明人: Hartmut Rehwinkel , Stefan Baeurle , Markus Berger , Norbert Schmees , Heike Schaecke , Konrad Krolikiewicz , Anne Mengel , Duy Nguyen , Stefan Jaroch , Werner Skuballa
IPC分类号: A61K31/135 , A61K31/195 , A61K31/277
CPC分类号: C07D209/34 , C07D213/74 , C07D215/04 , C07D215/227 , C07D215/38 , C07D215/60 , C07D217/24 , C07D231/56 , C07D237/32 , C07D239/74 , C07D277/64 , C07D307/88 , C07D405/12 , C07D471/04
摘要: The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及四氢萘衍生物,其制备方法及其作为抗炎剂的用途。
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