公开(公告)号：US12125561B2

公开(公告)日：2024-10-22

申请号：US16143708

申请日：2018-09-27

申请人： InnoSIGN B.V.

发明人： Meng Dou ,  Wilhelmus Franciscus Johannes Verhaegh ,  Anja Van De Stolpe ,  Rick Velter

IPC分类号： G16B5/00 ,  C12Q1/6851 ,  C12Q1/6886 ,  C40B10/00 ,  C40B20/00 ,  G01N33/68 ,  G16B5/20 ,  G16B20/00 ,  G16B25/00

CPC分类号： G16B5/00 ,  C12Q1/6851 ,  C12Q1/6886 ,  C40B10/00 ,  C40B20/00 ,  G01N33/6872 ,  G16B5/20 ,  G16B20/00 ,  G16B25/00 ,  C12N2501/42 ,  C12Q2600/158 ,  G01N2333/4703 ,  G01N2800/52 ,  C12Q1/6851 ,  C12Q2537/165

摘要： A bioinformatics process which provides an improved means to detect a JAK-STAT3 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT3 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT3 cellular signaling pathway target genes.

公开(公告)号：US11649488B2

公开(公告)日：2023-05-16

申请号：US16143885

申请日：2018-09-27

申请人： InnoSIGN B.V.

发明人： Wilhelmus Franciscus Johannes Verhaegh ,  Meng Dou ,  Anja Van De Stolpe ,  Rick Velter

IPC分类号： C12Q1/6886 ,  G16B25/10 ,  C12Q1/6851 ,  C12Q1/6844 ,  G16B5/20 ,  G16B25/00 ,  G16B50/00 ,  C12Q1/6809 ,  G06N7/00

CPC分类号： C12Q1/6851 ,  C12Q1/6809 ,  C12Q1/6844 ,  C12Q1/6886 ,  G06N7/005 ,  G16B5/20 ,  G16B25/00 ,  G16B50/00 ,  C12Q2600/158 ,  G16B25/10 ,  C12Q1/6844 ,  C12Q2537/165

摘要： A bioinformatics process which provides an improved means to detect a JAK-STAT1/2 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT1/2 cellular signaling pathway target genes.