公开(公告)号：US20210361681A1

公开(公告)日：2021-11-25

申请号：US16622473

申请日：2019-04-18

申请人： INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOOD

发明人： Takehiko FUJINO ,  Shiro MAWATARI

IPC分类号： A61K31/685 ,  A61K35/57 ,  A61K35/618 ,  A61K35/655 ,  A61P29/00 ,  C12P13/00

摘要： A method for manufacturing a functional material that contains plasmalogen, the method including treating an animal tissue containing plasmalogen with protease, and extracting the animal tissue treated with protease with an extraction liquid containing ethanol.

公开(公告)号：US20180327433A1

公开(公告)日：2018-11-15

申请号：US15533528

申请日：2015-05-13

申请人： Institute of Rheological Functions of Food

发明人： Takehiko FUJINO ,  Shiro MAWATARI

IPC分类号： C07F9/10 ,  A23L2/52 ,  A23L33/12 ,  A23J7/00 ,  C11B11/00 ,  A61K31/685

CPC分类号： C07F9/103 ,  A23J7/00 ,  A23L2/52 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/685 ,  A61K35/618 ,  C07F9/10 ,  C11B11/00

摘要： [PROBLEM TO BE SOLVED] It enables any superior ether phospholipids to the conventional ones and a method for producing the same in an easy manner on a massive scale, in light of effects of treating and improving brain diseases such as Alzheimer's disease, Parkinson disease, depression and schizophrenia, metabolic diseases such as diabetes, various infectious diseases, and immune disorders. [SOLUTION] Ether phospholipids are obtained from bivalve tissues such as clams and corbicula by extraction processing. The ether phospholipids exhibit significantly superior effects of the above as compared to the conventional ether phospholipids derived from chicken tissues.

公开(公告)号：US20210238208A1

公开(公告)日：2021-08-05

申请号：US17050905

申请日：2019-04-18

申请人： INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOOD

发明人： Takehiko FUJINO ,  Shiro MAWATARI ,  Toyoharu YAMASHITA ,  Mitsuru KITAMURA ,  Tatsuo OKAUCHI ,  Shamim HOSSAIN

IPC分类号： C07F9/10 ,  A61P25/28

摘要： A compound presented by the following Chemical Formula 1, a racemic form, or a salt thereof: wherein, X represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom, R1 represents R1a—Y—R1b (wherein R1a and R1b each independently represent a saturated or unsaturated aliphatic hydrocarbon group, an aromatic group, a heterocyclic group, or a combination thereof, and Y represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom), R2 represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.

公开(公告)号：US20210255165A1

公开(公告)日：2021-08-19

申请号：US16973172

申请日：2019-06-10

申请人： INSTITUTE OF RHEOLOGICAL FUNCTIONS OF FOOD

发明人： Takehiko FUJINO ,  Shiro MAWATARI ,  Tsunemichi KAWA ,  Tetsuji KOYAMA ,  Toyoharu YAMASHITA

IPC分类号： G01N33/49 ,  G01N15/10

摘要： A method for assessing aging of erythrocytes that includes preparing an erythrocyte suspension from a blood sample; a allowing the erythrocyte suspension to pass through a first filter, separating aged erythrocytes that do not pass through the first filter, and non-aged erythrocytes that pass through the first filter, and to calculate a deformability of erythrocytes, allowing the separated non-aged erythrocyte suspension to pass through a second filter having micropores which diameter is smaller than the first filter, separating mild aged erythrocytes that do not pass through the second filter and juvenile erythrocytes that pass through the second filter, and to calculate a deformability of the non-aged erythrocytes; and assessing aging of erythrocytes, using the deformability of erythrocyte and the deformability of non-aged erythrocyte.