公开(公告)号：US09752185B2

公开(公告)日：2017-09-05

申请号：US14824333

申请日：2015-08-12

Applicant: IntegenX Inc.

Inventor： Allen Boronkay ,  Stevan Bogdan Jovanovich ,  Iuliu Ioan Blaga

IPC: C12M1/00 ,  C12M1/34 ,  G01N15/06 ,  B01J19/08 ,  B01J19/12 ,  B01D21/00 ,  C12Q1/68 ,  B01F11/00 ,  B01F13/00 ,  C12Q1/24 ,  C12Q1/70 ,  C12N15/10 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N35/00

CPC classification number: C12Q1/6869 ,  B01F11/0071 ,  B01F13/0059 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502753 ,  B01L3/502761 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0668 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12N15/1003 ,  C12N15/1013 ,  C12Q1/24 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q1/70 ,  G01N2035/00514 ,  Y10T436/163333 ,  Y10T436/25875

Abstract: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense. Also disclosed in the present disclosure is a flow through, traveling-wave, bead-beating device which comprises a rotating pole piece, a flow through tube, and a magnetic piece. Rotation of the rotating pole piece may create a magnetic wave down the flow through tube, thereby producing sufficient acceleration of beads through the tube to disrupt or lyse target analytes flowing through the tube.