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公开(公告)号：US09970067B2
公开(公告)日：2018-05-15
申请号：US14943894
申请日：2015-11-17
发明人： Scott Rose , Kristin Beltz
IPC分类号： C12Q1/70 , C07K14/005 , C12Q1/68
CPC分类号： C12Q1/701 , C07K14/005 , C12Q1/6827 , C12Q1/6883
摘要： This invention relates to primers and probes for detecting Ebola virus and one or more subtypes of Ebola virus as well as kits including the probes and primers and methods of using the probes and primers.
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公开(公告)号：US09951327B1
公开(公告)日：2018-04-24
申请号：US14802989
申请日：2015-07-17
发明人： Scott D. Rose , Joseph A. Walder , Kristin Beltz , Shawn Allen
CPC分类号： C12N9/93 , C12N9/1252 , C12N9/16 , C12Y207/07007 , C12Y301/00 , C12Y605/01001
摘要： The invention is directed to an in vitro method for joining a first set of double-stranded (ds) DNA molecules. Small molecules acting as chaperone agents are identified that promote efficient and rapid assembly (that is, joining) of overlapping double-stranded DNA fragments.
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公开(公告)号：US12024742B2
公开(公告)日：2024-07-02
申请号：US17558994
申请日：2021-12-22
发明人： Joseph Dobosy , John Froehlig, Jr. , Katherine Perschbacher , Kristin Beltz , Scott Rose , Mark Aaron Behlke
IPC分类号： C12Q1/6848 , C12N9/22 , C12Q1/6853 , C12Q1/686
CPC分类号： C12Q1/6848 , C12N9/22 , C12Y301/26004 , C12Q1/6853 , C12Q1/686
摘要： The present invention pertains to hybrid RNase H2 proteins that include fragments of amino acid sequences from Pyrococcus abyssi (P.a.), Thermococcus kodakarensis (T.kod), and Pyrococcus furiosus organisms, as well as methods of using the same to improve mismatch discrimination and activity in a high-fidelity DNA polymerase buffer.
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公开(公告)号：US20150159152A1
公开(公告)日：2015-06-11
申请号：US14564504
申请日：2014-12-09
发明人： Shawn Allen , Kristin Beltz , Scott Rose
IPC分类号： C12N15/10
CPC分类号： C12N15/1031 , C12N15/10 , C12N15/102 , C12N15/1068 , C12N15/66
摘要： This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.
摘要翻译： 本发明涉及用于合成含有难以克隆或可变区的长双链核酸序列的改进方法。
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公开(公告)号：US20180023074A1
公开(公告)日：2018-01-25
申请号：US15645972
申请日：2017-07-10
发明人： Shawn Allen , Kristin Beltz , Scott Rose
CPC分类号： C12N15/1031 , C12N15/10 , C12N15/102 , C12N15/1068 , C12N15/66
摘要： This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.
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6.发明申请公开(公告)号：US20160145698A1
公开(公告)日：2016-05-26
申请号：US14943894
申请日：2015-11-17
发明人： Scott Rose , Kristin Beltz
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , C07K14/005 , C12Q1/6827 , C12Q1/6883
摘要： This invention relates to primers and probes for detecting Ebola virus and one or more subtypes of Ebola virus as well as kits including the probes and primers and methods of using the probes and primers.
摘要翻译： 本发明涉及用于检测埃博拉病毒和一种或多种埃博拉病毒亚型的引物和探针，以及包括探针和引物的试剂盒以及使用探针和引物的方法。
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公开(公告)号：US20240318237A1
公开(公告)日：2024-09-26
申请号：US18667876
申请日：2024-05-17
发明人： Joseph Dobosy , John Froehlig, JR. , Katherine Perschbacher , Kristin Beltz , Scott Rose , Mark Aaron Behlke
IPC分类号： C12Q1/6848 , C12N9/22 , C12Q1/6853 , C12Q1/686
CPC分类号： C12Q1/6848 , C12N9/22 , C12Y301/26004 , C12Q1/6853 , C12Q1/686
摘要： The present invention pertains to a kit for producing an extended primer, comprising at least one container providing a hybrid RNase H2 protein, including a hybrid RNase H2 protein comprising fragments of amino acid sequences from Pyrococcus abyssi (P. a.), Thermococcus kodakarensis (T. kod), and Pyrococcus furiosus organisms; a hybrid RNase H2 protein comprises amino acid residues 26-40 and residues 100-120 of T. kod RNase H2; a hybrid RNase H2 protein is selected from SEQ ID NO: 2 and 3; and a hybrid RNase H2 protein is selected from SEQ ID NO: 14-20.
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公开(公告)号：US20220348997A1
公开(公告)日：2022-11-03
申请号：US17558994
申请日：2021-12-22
发明人： Joseph Dobosy , John Froehlig, Jr. , Katherine Perschbacher , Kristin Beltz , Scott Rose , Mark Aaron Behlke
IPC分类号： C12Q1/6848 , C12N9/22
摘要： The present invention pertains to hybrid RNase H2 proteins that include fragments of amino acid sequences from Pyrococcus abyssi (P.a.), Thermococcus kodakarensis (T.kod), and Pyrococcus furiosus organisms, as well as methods of using the same to improve mismatch discrimination and activity in a high-fidelity DNA polymerase buffer.
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