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    Data storage based on encoded DNA sequences
    1.
    发明授权
    Data storage based on encoded DNA sequences 有权

    公开(公告)号：US11630863B2

    公开(公告)日：2023-04-18

    申请号：US17403791

    申请日：2021-08-16

    Applicant: Intel Corporation

    Inventor： Xing Su ,  Kai Wu ,  Noureddine Tayebi ,  Grace Credo

    IPC: G06F16/901 ,  H03M7/30 ,  G06F16/11 ,  G06F16/178 ,  G16B30/00 ,  G16B50/50

    Abstract: Devices, methods, and systems for encoding data as DNA are provided. An encoder device can include circuitry to encode a data file having a bit sequence encoding data and to generate a virtual DNA (VDNA) sequence of virtual nucleotide bases (Vnb) that reversibly encodes the bit sequence of the data file, divide the VDNA sequence into a plurality of VDNA fragments, associate each VDNA fragment with an archive library sequence (Arc_SEQ), and generate a read instruction (READ) sequence of differences between each VDNA fragment and each associated Arc_SEQ including sufficient instruction to facilitate regeneration of each VDNA fragment from each associated Arc_SEQ. A codeword sequence (Code_SEQ) is additionally generated for each VDNA fragment that includes a codename identifying the associated Arc_SEQ, the READ sequence associated with the VDNA fragment, and an index sequence (Idx_SEQ) including an index mapping of the VDNA fragment in the VDNA sequence.

    Massively parallel integrated circuit-based DNA synthesis devices, systems, and methods
    2.
    发明授权
    Massively parallel integrated circuit-based DNA synthesis devices, systems, and methods 有权

    公开(公告)号：US10704088B2

    公开(公告)日：2020-07-07

    申请号：US15929030

    申请日：2018-06-29

    Applicant: Intel Corporation

    Inventor： Xing Su ,  Grace Credo

    IPC: C12Q1/6844 ,  B01J19/00 ,  B01L3/00 ,  C07H21/04

    Abstract: DNA synthesis devices, systems, and methods are disclosed. An apparatus can include a synthesizer chip having an array of reaction units in a predetermined pattern, each reaction unit including a reaction surface and a reaction electrode of an IC array of reaction electrodes, and a synthesizer chip controller coupled to the IC array of reaction electrodes configured to address each reaction electrode individually. The apparatus can also include a reagent delivery chip positionable above the synthesizer chip, comprising an array of reagent delivery units arranged in the predetermined pattern, each reagent delivery unit including a reagent electrode of an IC array of reagent electrodes and each reagent delivery unit configured to receive and deliver a droplet of reagent fluid having a volume of 1 picoliter or less, and a reagent delivery chip controller coupled to the IC array of reagent electrodes configured to address each reagent electrode individually.

    Data storage based on encoded DNA sequences
    4.
    发明授权
    Data storage based on encoded DNA sequences 有权

    公开(公告)号：US11093547B2

    公开(公告)日：2021-08-17

    申请号：US15929022

    申请日：2018-06-19

    Applicant: Intel Corporation

    Inventor： Xing Su ,  Kai Wu ,  Noureddine Tayebi ,  Grace Credo

    IPC: H03M7/00 ,  G06F16/901 ,  H03M7/30 ,  G06F16/11 ,  G06F16/178 ,  G16B30/00 ,  G16B50/50

    Abstract: Devices, methods, and systems for encoding data as DNA are provided. An encoder device can include an encoder engine configured to encode a data file having a bit sequence encoding data and further configured to generate a virtual DNA (VDNA) sequence of virtual nucleotide bases (Vnb) that reversibly encodes the bit sequence of the data file, divide the VDNA sequence into a plurality of VDNA fragments, associate each VDNA fragment with an archive library sequence (Arc_SEQ), and generate a read instruction (READ) sequence of differences between each VDNA fragment and each associated Arc_SEQ including sufficient instruction to facilitate regeneration of each VDNA fragment from each associated Arc_SEQ. A codeword sequence (Code_SEQ) is additionally generated for each VDNA fragment comprising a codename identifying the associated Arc_SEQ, the READ sequence associated with the VDNA fragment, and an index sequence (Idx_SEQ) including an index mapping of the VDNA fragment in the VDNA sequence.

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