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公开(公告)号：US06191140B1
公开(公告)日：2001-02-20
申请号：US09421862
申请日：1999-10-20
申请人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
发明人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
IPC分类号： A61K3144
CPC分类号： C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
摘要： The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
摘要翻译： 本发明提供了可用于超极化细胞膜，开放钾通道，缓和平滑肌细胞和抑制膀胱收缩的新颖的式I化合物。
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2.发明授权Benzopyranopyrrole and benzopyranopyridine .alpha.-1 adenergic compounds 失效苯并吡喃并吡咯和苯并吡喃并吡啶α-1的能量化合物
公开(公告)号：US5891882A
公开(公告)日：1999-04-06
申请号：US975979
申请日：1997-11-21
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt
IPC分类号： C07D491/04 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00
CPC分类号： C07D491/04
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 adrenoreceptors and tr
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1肾上腺素受体的方法
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公开(公告)号：US06642222B2
公开(公告)日：2003-11-04
申请号：US09563287
申请日：2000-05-03
申请人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
发明人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
IPC分类号： A61K3155
CPC分类号： C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
摘要： The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
摘要翻译： 本发明提供了可用于超极化细胞膜，开放钾通道，缓和平滑肌细胞和抑制膀胱收缩的新型式I化合物。
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4.发明授权Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers 失效三环二氢吡唑酮和三环二氢异恶唑酮钾通道开放剂公开(公告)号：US06538004B2
公开(公告)日：2003-03-25
申请号：US09778551
申请日：2001-02-07
IPC分类号： A61K31437
CPC分类号： C07D471/04 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D491/14 , C07D495/14 , C07C47/55
摘要： Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
摘要翻译： 式I化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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5.发明授权Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists 失效三环取代六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：US5597823A
公开(公告)日：1997-01-28
申请号：US463528
申请日：1995-06-05
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
IPC分类号： A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/505
CPC分类号： C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是三环杂环体系; 其是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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6.发明授权Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers 失效三环二氢吡唑酮和三环二氢异恶唑酮钾通道开放剂公开(公告)号：US06780872B2
公开(公告)日：2004-08-24
申请号：US10349244
申请日：2003-01-22
IPC分类号： A61K31437
CPC分类号： C07D471/04 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D491/14 , C07D495/14 , C07C47/55
摘要： Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
摘要翻译： 式I化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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7.发明授权Benzopyranopyrrole and benzopyranopyridine .alpha.-1 adrenergic compounds 失效苯并吡喃并吡咯和苯并吡喃并吡啶α-1肾上腺素能化合物
公开(公告)号：US6046207A
公开(公告)日：2000-04-04
申请号：US980130
申请日：1997-11-26
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt , Anthony R. Haight , Weijiang Zhang
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt , Anthony R. Haight , Weijiang Zhang
IPC分类号： C07D491/04 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00
CPC分类号： C07D491/04
摘要： The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 adrenoreceptors and treating BPH.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1肾上腺素受体并治疗BPH的方法。
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8.发明授权Bicyclic substituted hexahydrobenz �e! isoindole alpha-1 adrenergic antagonists 失效双环取代的六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：US5792767A
公开(公告)日：1998-08-11
申请号：US465476
申请日：1995-06-05
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , John K. Pratt , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , John K. Pratt , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto
IPC分类号： A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D491/056 , C07D495/04 , C07D498/04 , A61K31/495 , C07D403/14
CPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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9.发明授权Bicyclic substituted hexahydrobenz[e]isoindole .alpha.-1 adrenergic antagonists 失效双环取代的六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：US5521181A
公开(公告)日：1996-05-28
申请号：US379823
申请日：1995-01-27
申请人： Michael D. Meyer , Robert J. Altenbach , William A. Carroll , Irene Drizin , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto , James F. Kerwin, Jr.
发明人： Michael D. Meyer , Robert J. Altenbach , William A. Carroll , Irene Drizin , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto , James F. Kerwin, Jr.
IPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D403/02 , A61K31/40 , A61K31/505 , C07D403/14
CPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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公开(公告)号：US08735411B2
公开(公告)日：2014-05-27
申请号：US11863559
申请日：2007-09-28
申请人： Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield , Kathryn J. Hancock
发明人： Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
IPC分类号： A61K31/505 , C07D239/70
CPC分类号： C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
摘要： Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
摘要翻译： 本文描述了大环苯并菲的嘧啶化合物，包含这些化合物的组合物，制备该化合物的方法，以及使用这些化合物和组合物治疗和预防疾病，病症和病症进展的方法。
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