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1.发明授权Benzopyranopyrrole and benzopyranopyridine .alpha.-1 adrenergic compounds 失效苯并吡喃并吡咯和苯并吡喃并吡啶α-1肾上腺素能化合物
公开(公告)号：US6046207A
公开(公告)日：2000-04-04
申请号：US980130
申请日：1997-11-26
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt , Anthony R. Haight , Weijiang Zhang
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt , Anthony R. Haight , Weijiang Zhang
IPC分类号： C07D491/04 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00
CPC分类号： C07D491/04
摘要： The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 adrenoreceptors and treating BPH.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1肾上腺素受体并治疗BPH的方法。
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2.发明授权Benzopyranopyrrole and benzopyranopyridine .alpha.-1 adenergic compounds 失效苯并吡喃并吡咯和苯并吡喃并吡啶α-1的能量化合物
公开(公告)号：US5891882A
公开(公告)日：1999-04-06
申请号：US975979
申请日：1997-11-21
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Michael D. Wendt
IPC分类号： C07D491/04 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00
CPC分类号： C07D491/04
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 adrenoreceptors and tr
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1肾上腺素受体的方法
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3.发明授权Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists 失效三环取代六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：US5597823A
公开(公告)日：1997-01-28
申请号：US463528
申请日：1995-06-05
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
IPC分类号： A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/505
CPC分类号： C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是三环杂环体系; 其是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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4.发明授权Bicyclic substituted hexahydrobenz �e! isoindole alpha-1 adrenergic antagonists 失效双环取代的六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：US5792767A
公开(公告)日：1998-08-11
申请号：US465476
申请日：1995-06-05
申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , John K. Pratt , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto
发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , John K. Pratt , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto
IPC分类号： A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D491/056 , C07D495/04 , C07D498/04 , A61K31/495 , C07D403/14
CPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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5.发明授权Bicyclic substituted hexahydrobenz[e]isoindole .alpha.-1 adrenergic antagonists 失效双环取代的六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：US5521181A
公开(公告)日：1996-05-28
申请号：US379823
申请日：1995-01-27
申请人： Michael D. Meyer , Robert J. Altenbach , William A. Carroll , Irene Drizin , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto , James F. Kerwin, Jr.
发明人： Michael D. Meyer , Robert J. Altenbach , William A. Carroll , Irene Drizin , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto , James F. Kerwin, Jr.
IPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D403/02 , A61K31/40 , A61K31/505 , C07D403/14
CPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是双环杂环体系。 该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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公开(公告)号：US06503935B1
公开(公告)日：2003-01-07
申请号：US09364901
申请日：1999-07-29
申请人： Robert J. Altenbach , Michael D. Meyer , James F. Kerwin, Jr. , Mark W. Holladay , Albert Khilevich , Teodozyj Kolasa , Jeffrey Rohde , William A. Carroll
发明人： Robert J. Altenbach , Michael D. Meyer , James F. Kerwin, Jr. , Mark W. Holladay , Albert Khilevich , Teodozyj Kolasa , Jeffrey Rohde , William A. Carroll
IPC分类号： A61K31425
CPC分类号： C07D233/64 , C07D233/84 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/12 , C07D417/12
摘要： Compounds having formula I: are useful in treating diseases prevented by or ameliorated with &agr;1A agonists. Also disclosed are &agr;1A agonist compositions and a method of activating &agr;1 adrenoceptors in a mammal.
摘要翻译： 具有式I的化合物可用于治疗由α1A激动剂预防或改善的疾病。 还公开了α1A激动剂组合物和在哺乳动物中激活α1肾上腺素受体的方法。
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公开(公告)号：US06191140B1
公开(公告)日：2001-02-20
申请号：US09421862
申请日：1999-10-20
申请人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
发明人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
IPC分类号： A61K3144
CPC分类号： C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
摘要： The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
摘要翻译： 本发明提供了可用于超极化细胞膜，开放钾通道，缓和平滑肌细胞和抑制膀胱收缩的新颖的式I化合物。
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8.发明授权Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers 失效三环二氢吡唑酮和三环二氢异恶唑酮钾通道开放剂公开(公告)号：US06780872B2
公开(公告)日：2004-08-24
申请号：US10349244
申请日：2003-01-22
IPC分类号： A61K31437
CPC分类号： C07D471/04 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D491/14 , C07D495/14 , C07C47/55
摘要： Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
摘要翻译： 式I化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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公开(公告)号：US06642222B2
公开(公告)日：2003-11-04
申请号：US09563287
申请日：2000-05-03
申请人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
发明人： William A. Carroll , Konstantinos A. Agrios , Robert J. Altenbach , Irene Drizin , Michael E. Kort
IPC分类号： A61K3155
CPC分类号： C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
摘要： The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
摘要翻译： 本发明提供了可用于超极化细胞膜，开放钾通道，缓和平滑肌细胞和抑制膀胱收缩的新型式I化合物。
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10.发明授权Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers 失效三环二氢吡唑酮和三环二氢异恶唑酮钾通道开放剂公开(公告)号：US06538004B2
公开(公告)日：2003-03-25
申请号：US09778551
申请日：2001-02-07
IPC分类号： A61K31437
CPC分类号： C07D471/04 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D491/14 , C07D495/14 , C07C47/55
摘要： Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
摘要翻译： 式I化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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