专利检索 ap:("Michael D. Meyer" OR "Robert J. Altenbach" OR "Fatima Z. Basha" OR "William A. Carroll" OR "Irene Drizin" OR "James F. Kerwin, Jr." OR "Suzanne A. Lebold" OR "Edmund L. Lee" OR "John K. Pratt" OR "Kevin B. Sippy" OR "Karin R. Tietje" OR "Diane M. Yamamoto") AND inv:"John K. Pratt" 第 1 页

1.

发明授权
Bicyclic substituted hexahydrobenz �e! isoindole alpha-1 adrenergic antagonists 失效
标题翻译：双环取代的六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂

公开(公告)号：US5792767A

公开(公告)日：1998-08-11

申请号：US465476

申请日：1995-06-05

申请人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , John K. Pratt , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto

发明人： Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , John K. Pratt , Kevin B. Sippy , Karin R. Tietje , Diane M. Yamamoto

IPC分类号： A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D491/056 , C07D495/04 , C07D498/04 , A61K31/495 , C07D403/14

CPC分类号： C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04

摘要： The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are .alpha.-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.

摘要翻译： 本发明涉及式IMA的化合物及其药学上可接受的盐，其中W是双环杂环体系。该化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。

2.

发明授权
Benzoxazine &agr;-1 adrenergic compounds 失效
标题翻译：苯并恶嗪α-1肾上腺素能化合物

公开(公告)号：US06376488B1

公开(公告)日：2002-04-23

申请号：US09657296

申请日：2000-09-07

申请人： Fatima Z. Basha , Michael D. Wendt , John K. Pratt

发明人： Fatima Z. Basha , Michael D. Wendt , John K. Pratt

IPC分类号： A61K315365

CPC分类号： C07D519/00

摘要： The present invention relates to compounds having formula I and to pharmaceutically acceptable salts thereof. Compounds of formula I inhibit &agr;1 adrenoreceptors and may be useful for treating benign prostatic hyperplasia (also called benign prostatic hypertrophy) and other urological diseases such as bladder outlet obstruction, neurogenic bladder and gynecological syndromes.

摘要翻译： 本发明涉及具有式I的化合物及其药学上可接受的盐。式I的化合物抑制α1肾上腺素受体，并且可用于治疗良性前列腺增生（也称为良性前列腺肥大）和其它泌尿系统疾病，例如膀胱出口阻塞，神经源性膀胱和妇科综合征。

3.

发明申请
HEPATITIS C INHIBITORS AND USES THEREOF 有权
标题翻译： HEPATITIS C抑制剂及其用途

公开(公告)号：US20140038919A1

公开(公告)日：2014-02-06

申请号：US13995701

申请日：2011-12-16

申请人： Clarence J. Maring , John K. Pratt , William A. Carroll , Dachun Liu , David A. Betebenner , Douglas K. Hutchinson , Michael D. Tufano , Todd W. Rockway , Uwe Schoen , Axel Pahl , Andreas Witte

发明人： Clarence J. Maring , John K. Pratt , William A. Carroll , Dachun Liu , David A. Betebenner , Douglas K. Hutchinson , Michael D. Tufano , Todd W. Rockway , Uwe Schoen , Axel Pahl , Andreas Witte

IPC分类号： C07D413/14 , A61K31/4178 , C07D417/14 , A61K31/427 , A61K31/422 , A61K31/5395 , A61K31/4245 , C07D471/04 , A61K31/437 , A61K31/513 , A61K31/5377 , A61K31/541 , C07F9/6558 , A61K31/675 , A61K45/06 , C07D405/04

CPC分类号： C07F7/1804 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/5395 , A61K31/541 , A61K31/675 , A61K31/695 , A61K45/06 , B65D88/703 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586 , F16K31/363 , Y10T137/86405 , Y10T137/86421

摘要： This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

摘要翻译： 本公开涉及：（a）其特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

4.

发明授权
Hepatitis C inhibitors and uses thereof 有权
标题翻译：丙型肝炎抑制剂及其用途

公开(公告)号：US09173887B2

公开(公告)日：2015-11-03

申请号：US13995701

申请日：2011-12-16

申请人： Clarence J. Maring , John K. Pratt , William A. Carroll , Dachun Liu , David A. Betebenner , Douglas K. Hutchinson , Michael D. Tufano , Todd W. Rockway , Uwe Schoen , Axel Pahl , Adreas Witte

发明人： Clarence J. Maring , John K. Pratt , William A. Carroll , Dachun Liu , David A. Betebenner , Douglas K. Hutchinson , Michael D. Tufano , Todd W. Rockway , Uwe Schoen , Axel Pahl , Adreas Witte

IPC分类号： C07D405/14 , C07D405/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/5395 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/437 , C07F7/18 , A61K31/4245 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07F9/6558

CPC分类号： C07F7/1804 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/5395 , A61K31/541 , A61K31/675 , A61K31/695 , A61K45/06 , B65D88/703 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586 , F16K31/363 , Y10T137/86405 , Y10T137/86421

摘要： This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

摘要翻译： 本公开涉及：（a）其特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

5.

发明授权
Anti-viral compounds 有权

公开(公告)号：US08937150B2

公开(公告)日：2015-01-20

申请号：US13100827

申请日：2011-05-04

申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll

发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll

IPC分类号： A61K31/66 , C07K16/00 , C07D401/14 , C07D491/113 , C07D413/14 , C07D403/14 , C07D417/14 , C07D405/14 , C07D453/00

CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

6.

发明申请
Anti-Viral Compounds 审中-公开

公开(公告)号：US20120220562A1

公开(公告)日：2012-08-30

申请号：US13404429

申请日：2012-02-24

申请人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll

发明人： David A DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , David A. Betebenner , Kathy Sarris , Kevin R. Woller , William A. Carroll

IPC分类号： A61K31/496 , A61K31/506 , A61K31/4545 , A61P31/14 , C07D403/14 , C07D401/14 , C07D405/14 , A61K31/4178 , A61K31/454

CPC分类号： C07D403/14 , C07D207/16

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

7.

发明授权
Anti-viral compounds 有权

公开(公告)号：US09394279B2

公开(公告)日：2016-07-19

申请号：US13328848

申请日：2011-12-16

申请人： Allan C. Krueger , Warren M. Kati , William A. Carroll , John K. Pratt , Douglas K. Hutchinson

发明人： Allan C. Krueger , Warren M. Kati , William A. Carroll , John K. Pratt , Douglas K. Hutchinson

IPC分类号： A61K31/66 , C07K16/00 , C07D403/14 , C07D207/16

CPC分类号： C07D403/14 , C07D207/16

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

8.

发明申请
Anti-Viral Compounds 有权

公开(公告)号：US20120172290A1

公开(公告)日：2012-07-05

申请号：US13328848

申请日：2011-12-16

申请人： Allan C. Krueger , Warren M. Kati , William A. Carroll , John K. Pratt , Douglas K. Hutchinson

发明人： Allan C. Krueger , Warren M. Kati , William A. Carroll , John K. Pratt , Douglas K. Hutchinson

IPC分类号： A61K38/05 , A61P31/14 , A61K31/4178 , A61K31/4184 , C07K5/062 , C07D403/14

CPC分类号： C07D403/14 , C07D207/16

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.