公开(公告)号：US5114721A

公开(公告)日：1992-05-19

申请号：US323705

申请日：1989-03-15

申请人： Irun R. Cohen ,  Meir Shinitzky ,  Richard L. Edelson

发明人： Irun R. Cohen ,  Meir Shinitzky ,  Richard L. Edelson

IPC分类号： A61K35/12 ,  A61K35/14 ,  A61K35/26 ,  A61K39/00 ,  A61P37/00

CPC分类号： A61K39/0008 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/903

摘要： Pharmaceutical preparations are provided for preventing or treating autoimmune diseases in which the active principle is activated T-lymphocyte cells, specific for the autoimmune disease to be treated, which cells have been treated by incubation with a photoactivatable psoralen cross-linking agent, such as 8-methoxypsoralen, and then photoactivated. The active principle may also be the membrane fraction of such cells. Such preparations may be formulated into pharmaceutical compositions and administered to prevent or treat autoimmune disesases.

公开(公告)号：US4634590A

公开(公告)日：1987-01-06

申请号：US648802

申请日：1984-09-07

申请人： Irun R. Cohen ,  Meir Shinitzky

发明人： Irun R. Cohen ,  Meir Shinitzky

IPC分类号： A61K39/00 ,  A61K35/12 ,  A61K35/26 ,  A61K38/00 ,  A61K38/16 ,  C07K14/705 ,  C07K3/28

CPC分类号： C07K14/705 ,  A61K38/00 ,  Y10S424/81 ,  Y10S435/82 ,  Y10S435/948 ,  Y10S530/806

摘要： Compositions for the prevention of, and for the treatment of autoimmune diseases which comprise as active ingredient membrane material shed from autoimmune T lymphocytes, or T lymphocytes activated by a pressure application and release process. There is also provided a process for obtaining such active materials and for preparing pharmaceutical compositions for these.

摘要翻译： 用于预防和治疗自身免疫性疾病的组合物，其包含作为活性成分从自身免疫T淋巴细胞脱落的膜材料或通过压力施用和释放过程激活的T淋巴细胞。 还提供了获得这种活性物质和制备这些活性物质的药物组合物的方法。

公开(公告)号：US06488933B2

公开(公告)日：2002-12-03

申请号：US08981861

申请日：1998-04-19

申请人： Irun R. Cohen ,  Dana Elias ,  Meir Shinitzky

发明人： Irun R. Cohen ,  Dana Elias ,  Meir Shinitzky

IPC分类号： A61K3900

CPC分类号： C07K16/18 ,  A61K9/0029 ,  A61K38/1709 ,  A61K39/0008 ,  A61K39/39 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K14/4713

摘要： Metabolizable lipid emulsions, such as Intralipid and Lipofundin, are excellent vehicles for peptide therapy of autoimmune diseases and of other TH1 T cell mediated diseases or conditions, as it promotes a TH1 to TH2 cytokine shift. Such emulsions may be used in conjunction with an antigen recognized by inflammatory T cells associated with the pathogenesis of a T cell mediated disease or condition for the therapeutic treatment of such

摘要翻译： 可代谢的脂质乳剂，如Intralipid和Lipofundin，是自身免疫疾病和其他TH1 T细胞介导的疾病或病症的肽治疗的优良载体，因为它促进TH1至TH2细胞因子转移。 这样的乳剂可以与由与T细胞介导的疾病或病症有关的炎性T细胞识别的抗原结合使用，用于治疗这些

公开(公告)号：US08987263B2

公开(公告)日：2015-03-24

申请号：US10530776

申请日：2003-10-09

申请人： Meir Shinitzky ,  Irun R. Cohen ,  Raanan Margalit ,  Yaacov Herzig ,  Jeffrey Sterling ,  Gyorgy Toth ,  Istvan Miskolczi ,  Ferenc Rantal ,  Tivadar Tamas

发明人： Meir Shinitzky ,  Irun R. Cohen ,  Raanan Margalit ,  Yaacov Herzig ,  Jeffrey Sterling ,  Gyorgy Toth ,  Istvan Miskolczi ,  Ferenc Rantal ,  Tivadar Tamas

IPC分类号： A61K31/5377 ,  A61K31/495 ,  A61K31/131 ,  C07D295/00 ,  C07C211/01 ,  A61K31/195 ,  A61K31/22 ,  A61K31/221 ,  A61K31/222 ,  A61K31/223 ,  A61K31/44 ,  A61K31/4425 ,  A61K45/06

CPC分类号： A61K31/195 ,  A61K31/22 ,  A61K31/221 ,  A61K31/222 ,  A61K31/223 ,  A61K31/44 ,  A61K31/4425 ,  A61K45/06

摘要： Basic esters of fatty alcohols of the general formula: R1-O—CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C12-C24 alkyl or C10-C24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.

摘要翻译： 脂肪醇的基本酯，其通式为：R 1 -O-CO-A或其药学上可接受的盐，其中R 1为C 12 -C 24烷基或C 10 -C 24烯基，A为含有至少一个无环或环状氨基的残基 和/或含有叔或季氮原子的至少一个杂芳环是用于治疗免疫介导的炎症的抗炎和免疫调节剂，作为参与细胞和体液应答的抗原的佐剂。

公开(公告)号：USRE35277E

公开(公告)日：1996-06-18

申请号：US242961

申请日：1988-09-06

申请人： Irun R. Cohen ,  Meir Shinitzky

发明人： Irun R. Cohen ,  Meir Shinitzky

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K14/725

CPC分类号： C07K14/705 ,  A61K38/00

摘要： Compositions for the prevention of, and for the treatment of autoimmune diseases which comprise as active ingredient membrane material shed from autoimmune T lymphocytes, or T lymphocytes activated by a pressure application and release process. There is also provided a process for obtaining such active materials and for preparing pharmaceutical compositions for these.

公开(公告)号：US4996194A

公开(公告)日：1991-02-26

申请号：US910876

申请日：1986-09-23

申请人： Irun R. Cohen ,  Meir Shinitzky

发明人： Irun R. Cohen ,  Meir Shinitzky

IPC分类号： A61K39/00 ,  A61K35/12 ,  A61K35/26 ,  A61K38/00 ,  A61K38/16 ,  C07K14/705

CPC分类号： C07K14/705 ,  A61K38/00 ,  Y10S424/81 ,  Y10S435/82 ,  Y10S435/948 ,  Y10S530/806

摘要： Composition for the prevention and treatment of autoimmune diseases are provided which comprise as an active ingredient membrane material shed from autoimmune T lymphocytes, or activated T lymphocytes which are treated by a pressure application and releases process. There is also provided processes for obtaining such active materials and for preparing pharmaceutical compositions containing them.

摘要翻译： 提供了用于预防和治疗自身免疫性疾病的组合物，其包含作为活性成分从自身免疫性T淋巴细胞脱落的膜材料或通过压力施加和释放过程处理的活化T淋巴细胞。 还提供了获得这种活性物质和制备含有它们的药物组合物的方法。

公开(公告)号：US4931275A

公开(公告)日：1990-06-05

申请号：US198691

申请日：1988-05-24

申请人： Meir Shinitzky ,  Irun R. Cohen

发明人： Meir Shinitzky ,  Irun R. Cohen

IPC分类号： A61K39/00 ,  C07K2/00

CPC分类号： C07K2/00 ,  A61K39/00 ,  Y10S530/806 ,  Y10S530/828

摘要： There are provided anti-tumor vaccines which contain as active ingredient tumor cells which have been pressure treated so as to augment their antigenic properties, tumor cells treated with cholesteryl hemisuccinate (CHS) and subsequently pressure treated, or plasma membranes from either of, or membrane proteins shed from either of these cells, or a combination of any of these. According to another embodiment, tumor cells are treated with cholesteryl hemisuccinate or by the application and release of pressure, and subsequently with a cross-linking agent. Such cells, plasma membranes obtained from these and proteins shed from the surface of these are effective active ingredients in anti-tumor vaccines.

摘要翻译： 提供抗肿瘤疫苗，其包含作为活性成分的肿瘤细胞，其已经被加压处理以增强其抗原性质，用胆固醇半琥珀酸盐（CHS）处理的肿瘤细胞并随后进行压力处理，或从任何一个或多个膜 从这些细胞中的任一个中分离的蛋白质，或这些细胞的组合。 根据另一个实施方案，用胆固醇基半琥珀酸盐或通过施加和释放压力，随后用交联剂处理肿瘤细胞。 这些细胞，从这些获得的质膜和从其表面脱落的蛋白质是抗肿瘤疫苗中的有效活性成分。

公开(公告)号：US09078843B2

公开(公告)日：2015-07-14

申请号：US12067652

申请日：2006-09-21

申请人： Irun R. Cohen ,  Francisco J. Quintana

发明人： Irun R. Cohen ,  Francisco J. Quintana

IPC分类号： A61K38/10 ,  A61K39/00 ,  G01N33/68

CPC分类号： A61K39/0008 ,  A61K2039/53 ,  A61K2039/645 ,  G01N33/564 ,  G01N33/6854 ,  G01N2333/7051 ,  G01N2800/102

摘要： The present invention is directed to an isolated T-Cell Receptor constant domain and to peptides derived therefrom and recombinant constructs encoding same, effective in therapy of T cell mediated inflammatory disease, autoimmunity and graft rejection. Therapeutic and prophylactic vaccine compositions and methods utilizing these proteins and peptides, DNA vaccines encoding same and T cell vaccines thereof are further provided.

摘要翻译： 本发明涉及分离的T细胞受体恒定结构域和衍生自其的肽和编码它们的重组构建体，其有效治疗T细胞介导的炎性疾病，自身免疫和移植排斥反应。 还提供了使用这些蛋白质和肽的治疗和预防性疫苗组合物和方法，编码它们的DNA疫苗和其T细胞疫苗。

公开(公告)号：US08361987B2

公开(公告)日：2013-01-29

申请号：US13293722

申请日：2011-11-10

申请人： Irun R. Cohen ,  Francisco J. Quintana ,  Pnina Carmi ,  Felix Mor

发明人： Irun R. Cohen ,  Francisco J. Quintana ,  Pnina Carmi ,  Felix Mor

IPC分类号： A61K9/127 ,  A61K31/7052 ,  A61K35/12 ,  A61P37/06

CPC分类号： A61K39/0008 ,  A61K31/7088 ,  A61K38/1709 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57

摘要： The present invention is related to a method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 60 (HSP60), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences, and wherein the disease is other than insulin dependent diabetes mellitus (IDDM), thereby treating the disease.

摘要翻译： 本发明涉及通过向有需要的个体施用免疫原性组合物来治疗T细胞介导的炎症性自身免疫疾病的方法，所述免疫原性组合物包含编码热休克蛋白60（HSP60）的核酸序列的重组构建体或活性 其中所述核酸序列与一个或多个转录调控序列有效连接，并且其中所述疾病不是胰岛素依赖型糖尿病（IDDM），从而治疗该疾病。

公开(公告)号：US20100189750A1

公开(公告)日：2010-07-29

申请号：US12677543

申请日：2008-09-11

申请人： Ilan Volovitz ,  Lea Eisenbach ,  Irun R. Cohen ,  Zvi Ram ,  Shimon Slavin

发明人： Ilan Volovitz ,  Lea Eisenbach ,  Irun R. Cohen ,  Zvi Ram ,  Shimon Slavin

IPC分类号： A61K39/00 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K2039/5152

摘要： A method of treating cancer in an immune-privileged site of a subject in need thereof is provided. The method comprises systemically administering to an area outside the immune-privileged site of the subject, a therapeutically effective amount of naive, viable cells of a tumor of the subject, the tumor being in the immune-privileged site so as to generate an immune response in the subject, thereby treating the cancer in the immune-privileged site of the subject.

摘要翻译： 提供了在有需要的受试者的免疫特异部位中治疗癌症的方法。 该方法包括系统地施用受试者的免疫特权部位之外的区域，治疗有效量的受试者肿瘤的天真，活的细胞，肿瘤位于免疫特异位点以产生免疫应答 从而治疗受试者的免疫特异部位的癌症。