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    Cyclic glycerophosphates and analogs thereof
    1.
    发明授权
    Cyclic glycerophosphates and analogs thereof 失效
    环状甘油磷酸酯及其类似物

    公开(公告)号：US06872712B1

    公开(公告)日：2005-03-29

    申请号：US09937386

    申请日：2000-03-24

    Applicant: Meir Shinitzky

    Inventor： Meir Shinitzky

    IPC: A61K31/665 ,  A61P3/10 ,  A61P5/10 ,  A61P5/50 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07F9/6574 ,  A61K31/66 ,  C07F9/02

    CPC classification number: A61K31/665 ,  C07F9/65742

    Abstract: Cyclic glycerophosphates as well as some analogs thereof (CGs) are shown to increase phosphorylation of intracellular proteins in various cells. Such activity is not found with linear α or β glycerophosphates. The phosphorylating activity of the CGs render them useful in the prevention and treatment of various disorders and diseases such as, for example, different kinds of malignancies as well as disorders involving hormone and hormone-like signaling. The CGs are also useful for promotion of target cell differentiation and for detection of abnormal conditions in target cells.

    Abstract translation: 循环甘油磷酸盐及其一些类似物（CG）显示增加各种细胞中细胞内蛋白质的磷酸化。 线性α或β甘油磷酸酯没有发现此类活性。 CG的磷酸化活性使其可用于预防和治疗各种疾病和疾病，例如不同种类的恶性肿瘤以及涉及激素和激素样信号传导的疾病。 CGs也可用于促进靶细胞分化和靶细胞异常情况的检测。

    Skin test for schizophrenia
    5.
    发明授权
    Skin test for schizophrenia 失效
    精神分裂症皮肤试验

    公开(公告)号：US07070760B1

    公开(公告)日：2006-07-04

    申请号：US09555964

    申请日：1998-12-07

    Applicant: Meir Shinitzky ,  Michael Deckmann

    Inventor： Meir Shinitzky ,  Michael Deckmann

    IPC: A61K49/14 ,  G01N33/53 ,  G01N33/555 ,  G01N33/567

    CPC classification number: G01N33/6896 ,  G01N2800/302 ,  Y10S436/811

    Abstract: A diagnostic method for assaying schizophrenia in a subject is provided wherein a preparation comprising platelet derived proteins or fractions thereof having a pI above about 6.5 is injected into a subject and the occurrence of delayed type hypersensitivity (DTH) reaction at the site of the injection is determined. A positive DTH reaction indicates that the tested subject has a high likelihood of being schizophrenic. The protein preparation used in the diagnostic method is also provided as well as a method for its preparation and a kit for use in the diagnosis of schizophrenia using the above method.

    Abstract translation: 提供了一种用于测定受试者中的精神分裂症的诊断方法，其中将含有pI高于约6.5的血小板衍生蛋白或其级分的制剂注射到受试者中，并且在注射部位发生迟发型超敏反应（DTH）反应是 决心。 正面的DTH反应表明被测试的受试者有很高的精神分裂症的可能性。 还提供了诊断方法中使用的蛋白质制剂以及其制备方法和使用上述方法用于诊断精神分裂症的试剂盒。

    Diagnosis of the susceptibility of contracting schizophrenia
    7.
    发明授权
    Diagnosis of the susceptibility of contracting schizophrenia 失效
    诊断精神分裂症患者易感性

    公开(公告)号：US6008001A

    公开(公告)日：1999-12-28

    申请号：US637786

    申请日：1996-05-06

    Applicant: Meir Shinitzky

    Inventor： Meir Shinitzky

    IPC: G01N33/68 ,  G01N33/80 ,  G01N33/53

    CPC classification number: G01N33/6857 ,  G01N33/80 ,  C07K2317/55 ,  G01N2800/302 ,  Y10S436/811

    Abstract: There is described an assay for the diagnosis of a mental disorder in an individual. A blood sample, a platelet-containing fraction thereof, or a fraction containing platelet-associated antibodies (PAA) shed from the platelets is withdrawn from the individual to be diagnosed. The withdrawn sample is contacted with an anti-human immunoglobulin antibody lacking the Fc domain (Fc-less anti-hIg antibody) and the degree of binding thereof to the PAA is determined. A degree of binding above that found in normal individuals indicates that diagnosed individual has a high likelihood of having a mental disorder.

    Abstract translation: PCT No.PCT / US94 / 12228 Sec。 371日期：1996年5月6日 102（e）日期1996年5月6日PCT 1994年10月27日PCT PCT。 WO95 / 12685 PCT公开号 日期1995年5月11日描述了个体精神障碍诊断的检测方法。 从血液样本，含有血小板的部分或从血小板脱落的含有血小板相关抗体（PAA）的部分从个体中取出以被诊断。 将取出的样品与缺乏Fc结构域的抗人免疫球蛋白抗体（Fc-抗-hIg抗体）接触，并测定其与PAA的结合程度。 在正常个体以上发现的一定程度的结合表明诊断的个体具有精神障碍的可能性很高。

    Anti-obesity drugs
    8.
    发明授权
    Anti-obesity drugs 失效
    抗肥胖药

    公开(公告)号：US5602164A

    公开(公告)日：1997-02-11

    申请号：US616948

    申请日：1996-03-18

    Applicant: Meir Shinitzky ,  Avner Shenfeld

    Inventor： Meir Shinitzky ,  Avner Shenfeld

    IPC: A61K31/195 ,  A61K31/215 ,  A61K31/415 ,  A61K31/235 ,  A61K31/24 ,  A61K31/40

    CPC classification number: A61K31/195 ,  A61K31/215 ,  Y10S514/909

    Abstract: Obesity is treated by the administration to a subject of a compound having the general formula (I): R.sub.4 --(CH.sub.2).sub.n --CO--N(R.sub.1)--CH(R.sub.2)--CO(--R.sub.3), wherein R.sub.1 represents H or CH.sub.3 ; R.sub.2 represents a side chain of a naturally occurring amino acid; R.sub.3 represents OH, OCH.sub.2 CH.sub.3 and NH.sub.2 ; n is 6-18; and R.sub.4 represents CH.sub.3 or a group having the general formula (II): R.sub.3 --CO--CH(R.sub.2)--N(R.sub.1)--CO--, wherein R.sub.1, R.sub.2 and R.sub.3 have the above meanings. The compounds of formula (I) wherein R.sub.4 is a group of formula (II), are novel compounds.

    Abstract translation: 通过向具有通式（I）的化合物的受试者给予肥胖症：R4-（CH2）n-CO-N（R1）-CH（R2）-CO（-R3），其中R1表示H或 CH3; R2表示天然存在的氨基酸的侧链; R3表示OH，OCH2CH3和NH2; n是6-18; 并且R 4表示CH 3或具有通式（II）的基团：R 3 -CO-CH（R 2）-N（R 1）-CO-，其中R 1，R 2和R 3具有上述含义。 其中R4为式（Ⅱ）基团的式（Ⅰ）化合物是新化合物。

    Method of detecting abnormal behavior of mammalian cells
    9.
    发明授权
    Method of detecting abnormal behavior of mammalian cells 失效
    检测哺乳动物细胞异常行为的方法

    公开(公告)号：US3971952A

    公开(公告)日：1976-07-27

    申请号：US505530

    申请日：1974-09-12

    Applicant: Michael Inbar ,  Meir Shinitzky

    Inventor： Michael Inbar ,  Meir Shinitzky

    IPC: A61D13/00 ,  G01N21/64 ,  G01N21/38

    CPC classification number: G01N21/6445

    Abstract: Abnormal behavior of mammalian cells is detected in vitro by measuring the fluidity or an associated phenomenon of the lipid layer of the cell surface membrane. Abnormal behavior of cells, in particular if caused by malignant transformations, is associated with increase of fluidity of the liquid layer of the cell membrane, as compared with normal cells. The fluidity can be determined, e.g., by measuring the degree of fluorescence polarization of the radiation emitted from a suspension of cells labelled in the lipid layer with a fluorescent compound. 1,6-Diphenyl-1,3,5-hexatriene was found to be a suitable fluorescent probe.

    Abstract translation: 通过测量细胞表面膜的脂质层的流动性或相关现象，在体外检测哺乳动物细胞的异常行为。 与正常细胞相比，特别是恶性转化引起的细胞的异常行为与细胞膜的液体层的流动性的增加相关。 流动性可以例如通过测量由荧光化合物在脂质层中标记的细胞的悬浮液发射的辐射的荧光偏振度来确定。 发现1,6-二苯基-1,3,5-己三烯是合适的荧光探针。

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