公开(公告)号：US20240207038A1

公开(公告)日：2024-06-27

申请号：US18434227

申请日：2024-02-06

申请人： ARTHREX, INC.

发明人： DAVID O. SHEPARD ,  JOHN TOKISH ,  REINHOLD SCHMEIDING ,  ADAM ANZ ,  STEVE JORDAN

IPC分类号： A61F2/08 ,  A61L17/08 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61F2/08 ,  A61L17/08 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3658 ,  A61L27/3662 ,  A61L27/367 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3856 ,  A61L27/386 ,  A61L27/3873 ,  A61L27/3886 ,  A61L27/54 ,  A61L27/58 ,  A61L2430/10

摘要： The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.

公开(公告)号：US11992517B2

公开(公告)日：2024-05-28

申请号：US16368042

申请日：2019-03-28

申请人： NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： Matthew E. Cunningham ,  Agata Krzyzanowska

IPC分类号： C12N5/077 ,  A61K9/00 ,  A61K31/195 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/32 ,  A61K38/19 ,  A61K38/20 ,  A61K38/46 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  A61P19/02 ,  C07K14/47 ,  C12N5/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/55 ,  C12N15/86

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/195 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/32 ,  A61K38/191 ,  A61K38/2006 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61L27/3658 ,  A61L27/3687 ,  A61L27/3821 ,  A61L27/3856 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/58 ,  C07K14/4702 ,  C12N5/0655 ,  C12N15/1138 ,  C12N15/86 ,  A61L2300/412 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/38 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2501/2301 ,  C12N2501/73 ,  C12N2740/16043 ,  C12Y301/03001 ,  A61K31/195 ,  A61K2300/00 ,  A61K31/675 ,  A61K2300/00 ,  A61K31/7076 ,  A61K2300/00

摘要： This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.

公开(公告)号：US11925727B2

公开(公告)日：2024-03-12

申请号：US17384824

申请日：2021-07-26

申请人： National Taiwan University

发明人： Wei-Hsing Tuan

IPC分类号： A61F2/44 ,  A61L27/06 ,  A61L27/10 ,  A61L27/38 ,  A61L27/40 ,  A61L27/56

CPC分类号： A61L27/3856 ,  A61L27/06 ,  A61L27/105 ,  A61L27/40 ,  A61L27/56 ,  A61L2430/38

摘要： An intervertebral fusion device includes a structural ceramic body. The structural ceramic body has a bottom surface, a top surface, a peripheral surface connected between the bottom surface and the top surface, and at least one pore channel penetrating the bottom surface and the top surface. The inner surface of the pore channel is either a convex curved surface or a funnel-shaped surface. For the pore channel having the convex curved surface, the pore diameter of the pore channel gradually expands from the center of the pore channel to the top surface and the bottom surface. The pore diameter can also gradually expand from the bottom surface to the top surface. The peripheral surface of the structural ceramic body is wavy or zigzag.

公开(公告)号：US20240058507A1

公开(公告)日：2024-02-22

申请号：US18270069

申请日：2022-01-10

申请人： THE UNIVERSITY OF HONG KONG

发明人： Pui Barbara CHAN ,  Xing Xing YANG

IPC分类号： A61L27/38 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26

CPC分类号： A61L27/3856 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3834 ,  A61L2430/06 ,  A61L2430/38

摘要： A composition comprising a glycosaminoglycan component, and one or more extracellular matrix components forming a precipitate with the glycosaminoglycan component, wherein the precipitate has a glycosaminoglycan to hydroxyproline ratio from about 1:10 to about 100:1. In particular, it is a GAG-rich composition with controllable and high glycosaminoglycan (GAG) content that mimics the extracellular matrix (ECM) of GAG-rich native tissues. Also provided is a method of making and using the aforesaid composition. Further provided is a method of treating a tissue disorder in a subject using the aforesaid composition. The composition may be used as scaffolds for applications such as microcarriers, 3D culture substrates, swelling agent, volume filling agent, replacement of nucleus pulposus, cartilage, and other GAG-rich tissues.

公开(公告)号：US20240024537A1

公开(公告)日：2024-01-25

申请号：US18105204

申请日：2023-02-02

申请人： Cornell University

发明人： Lawrence J. BONASSAR ,  Roger HARTL ,  Robert D. BOWLES ,  Harry H. GEBHARD

IPC分类号： A61L27/36 ,  A61K35/32 ,  A61L27/20 ,  A61L27/24 ,  A61L27/38 ,  A61L27/52 ,  A61F2/44 ,  A61L27/22 ,  A61L27/44

CPC分类号： A61L27/3658 ,  A61K35/32 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3817 ,  A61L27/3886 ,  A61L27/52 ,  A61L27/3856 ,  A61F2/442 ,  A61L27/22 ,  A61L27/44 ,  A61L27/3691 ,  A61F2002/4435 ,  A61F2002/4445 ,  A61F2002/445 ,  A61L2430/38 ,  A61F2002/444

摘要： The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs.

公开(公告)号：US20180325689A1

公开(公告)日：2018-11-15

申请号：US16037645

申请日：2018-07-17

申请人： University of Central Oklahoma

发明人： Morshed KHANDAKER ,  Shahram RIAHINEZHAD

IPC分类号： A61F2/44 ,  A61L27/38 ,  A61L27/18 ,  A61L27/34 ,  A61L27/52 ,  A61L27/26

CPC分类号： A61F2/441 ,  A61F2002/4495 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3817 ,  A61L27/3856 ,  A61L27/52 ,  A61L2400/12 ,  A61L2430/38 ,  C08L83/04 ,  C08L71/02 ,  C08L67/04 ,  C08L89/06

摘要： The present invention provides a process by which both non-tissue engineered and tissue engineered cartilaginous-like structures can be fabricated. The process of the present invention provides a method to produce electrospun nanofiber-anchored NP gels. The present invention provides a functional design for novel engineered IVD. The present invention provides a method for fabrication of both non-tissue and tissue engineered IVDs. These cartilaginous-like structures can be used to produce replacements for degenerated natural IVD. The method of the present invention uses electrospun PCL nanofiber mesh to anchor the NP. The method of the present invention can create angle-ply AF structure around the circumference of NP to mimic the architecture of native IVD. The method of the present invention anchors the top and bottom sides of NP by using non-woven aligned or random nanofiber mesh to create scaffold for the generation of endplate (EP) tissue.

公开(公告)号：US20160263200A1

公开(公告)日：2016-09-15

申请号：US15028997

申请日：2014-10-15

申请人： NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY

发明人： Matthew E. Cunningham ,  Agata Krzyzanowska

IPC分类号： A61K38/46 ,  A61K38/19 ,  A61K38/20 ,  C12N15/113 ,  A61L27/36 ,  A61K9/00 ,  A61L27/58 ,  A61L27/54 ,  A61L27/38 ,  A61K35/32 ,  A61K45/06

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/195 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/713 ,  A61K35/32 ,  A61K38/191 ,  A61K38/2006 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  A61L27/3658 ,  A61L27/3687 ,  A61L27/3821 ,  A61L27/3856 ,  A61L27/3895 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/38 ,  C07K14/4702 ,  C12N5/0655 ,  C12N15/1138 ,  C12N15/86 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2501/2301 ,  C12N2501/73 ,  C12N2740/16043 ,  C12Y301/03001 ,  A61K2300/00

摘要： This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.

摘要翻译： 本发明涉及用于激活和促进​​组织中矿化的组合物和方法，其通常不会矿化，特别是椎间盘。 该组合物包含增加编码TNAP的基因和/或TNAP蛋白的活化，量或活性的表达的试剂和降低ANK和/或ENPP表达和/或其活化，量或活性的试剂 蛋白质。 组合物可以是细胞或细胞的形式。 本发明还涉及使用该组合物的方法。

公开(公告)号：US08916691B2

公开(公告)日：2014-12-23

申请号：US11545349

申请日：2006-10-10

申请人： Scott D. Boden ,  Sreedhara Sangadala ,  F. Louisa Titus ,  William F. McKay

发明人： Scott D. Boden ,  Sreedhara Sangadala ,  F. Louisa Titus ,  William F. McKay

IPC分类号： C07K1/36 ,  C07K1/22 ,  C07K14/435 ,  C07K16/18 ,  C07K14/78 ,  A61L27/38 ,  C07K14/47 ,  A61K48/00 ,  A61K35/12 ,  A61K35/00

CPC分类号： A61L27/3856 ,  A61K35/12 ,  A61K35/13 ,  A61K48/00 ,  A61K2121/00 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C12N2799/022

摘要： Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in prokaryotic and non-mammalian eukaryotic cells are also described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein. Transfection may be accomplished in vitro, ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid.

摘要翻译： 描述了在哺乳动物细胞中表达LIM矿化蛋白的方法。 还描述了在原核和非哺乳动物真核细胞中表达LIM矿化蛋白和评估LIM矿化蛋白的糖基化的方法。 所述方法包括用包含编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。 转染可以通过直接注射病毒或裸露DNA或非病毒载体如质粒在体外，离体或体内完成。

公开(公告)号：US08696750B2

公开(公告)日：2014-04-15

申请号：US12526790

申请日：2008-02-14

申请人： J. Paul Santerre ,  Rita Kandel

发明人： J. Paul Santerre ,  Rita Kandel

IPC分类号： A61F2/44

CPC分类号： A61L27/3856 ,  A61F2/442 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2002/4495 ,  A61L27/18 ,  A61L27/3817 ,  A61L27/3852 ,  A61L2430/38 ,  C07C59/305 ,  C08G18/4854 ,  C08G18/672 ,  C08G18/771 ,  C08L75/08 ,  C12N5/0068 ,  C12N11/08 ,  C12N2533/30 ,  C08L75/04

摘要： The present invention relates to a fibrous scaffold for use as a substrate in soft tissue applications, in particular for preparing annulus fibrosus (AF) tissue. In aspects, the present invention also relates to an engineered biological material comprising AF tissue; constructs comprising one or more engineered biological materials; methods for producing the biological materials and constructs; and methods of using the biological materials and constructs.

摘要翻译： 本发明涉及在软组织应用中用作底物的纤维支架，特别是用于制备纤维环（AF）组织。 在各方面，本发明还涉及包含AF组织的工程生物材料; 包含一种或多种工程化生物材料的构建体; 用于生产生物材料和构建体的方法; 以及使用生物材料和构建体的方法。

公开(公告)号：US08163554B2

公开(公告)日：2012-04-24

申请号：US11858716

申请日：2007-09-20

申请人： Rita Kandel

发明人： Rita Kandel

IPC分类号： C12N5/077

CPC分类号： A61L27/3856 ,  A61F2/28 ,  A61F2002/30678 ,  A61F2002/4435 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2310/00359 ,  A61L27/3612 ,  A61L27/3633 ,  A61L27/3817 ,  A61L2430/38

摘要： The present invention relates to an engineered biological material comprising or enriched for tissue of intervertebral disc; tissue derived from an engineered biological material; constructs comprising one or more tissues from an engineered biological material; methods for producing the engineered biological materials and constructs; and methods of using the engineered biological materials and constructs.

摘要翻译： 本发明涉及包含或富集椎间盘组织的工程生物材料; 衍生自工程生物材料的组织; 包含来自工程生物材料的一种或多种组织的构建体; 用于生产工程生物材料和构建体的方法; 以及使用工程化生物材料和构建体的方法。