利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.02 秒)

    Process for preparing M- or P-substituted phenylalkanols by alkylation
    7.
    发明授权
    Process for preparing M- or P-substituted phenylalkanols by alkylation 有权
    通过烷基化制备M-或P-取代的苯基链烷醇的方法

    公开(公告)号：US08692025B2

    公开(公告)日：2014-04-08

    申请号：US13503515

    申请日：2010-10-14

    申请人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

    发明人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

    IPC分类号： C07C45/29 ,  C07C29/32

    CPC分类号： C07C29/32 ,  C07C29/56 ,  C07C45/29 ,  C07C33/20 ,  C07C47/228

    摘要： The invention relates to a process for the preparation of m- or p-substituted phenylalkanols of the formula (I) in which R1 is bonded to the phenyl ring in the m- or p-position and is C1-C5-alkyl, and R2, R3, R4 and R5, independently of one another, are hydrogen or methyl, wherein an unsubstituted phenylalkanol of the formula (II) in which R2, R3, R4 and R5 have the meanings given under formula (I) is alkylated together with a C1-C5-alkyl halide of the formula (III) R1-Hal  (III), in which R1 has the meaning given under formula (I) and Hal is halogen, in the presence of a Friedel-Crafts catalyst to give an m- or p-alkyl-substituted phenylalkanol of the formula (I), then the reaction mixture is worked-up and the desired m- or p-alkyl-substituted phenylalkanol of the formula (I) is separated off, the other formed by-products are returned to the reaction mixture and these are isomerized in the presence of a Friedel-Crafts catalyst to give the desired m- or p-alkyl-substituted phenylalkanol. From the m- or p-alkyl-substituted phenylalkanols of the formula (I), it is possible to form, by oxidation or dehydrogenation, as products of value, the corresponding aldehydes, which play an interesting role as fragrances and aroma chemicals.

    摘要翻译： 本发明涉及一种制备式（I）的间 - 或对 - 取代的苯烷醇的方法，其中R 1与m-或p-位上的苯环键合并且是C1-C5-烷基，R2 R 3，R 4和R 5彼此独立地为氢或甲基，其中R 2，R 3，R 4和R 5具有式（I）所示含义的式（II）的未取代的苯基烷醇与 其中R 1具有式（I）所示含义，Hal为卤素的式（III）R1-Hal（Ⅲ）的C1-C5烷基卤化物，在Friedel-Crafts催化剂存在下，得到m- 或式（I）的对烷基取代的苯基链烷醇，然后将反应混合物处理并分离所需的式（I）的间 - 或对 - 烷基取代的苯基烷醇，另一个形成的副产物 返回到反应混合物中，并将它们在Friedel-Crafts催化剂存在下异构化，得到所需的间 - 或对 - 烷基取代的苯基 kanol 从式（I）的间 - 或对 - 烷基取代的苯烷醇，可以通过氧化或脱氢形成作为有价值的产物，相应的醛作为香料和香气化学品起着重要的作用。

    Method for producing 2-substituted tetrahydropyranols
    8.
    发明授权
    Method for producing 2-substituted tetrahydropyranols 有权
    2-取代四氢吡喃醇的制备方法

    公开(公告)号：US08618315B2

    公开(公告)日：2013-12-31

    申请号：US13321417

    申请日：2010-05-11

    申请人： Gabriele Gralla ,  Ralf Pelzer ,  Klaus Ebel ,  Ulrich Griesbach ,  Jörg Botzem

    发明人： Gabriele Gralla ,  Ralf Pelzer ,  Klaus Ebel ,  Ulrich Griesbach ,  Jörg Botzem

    IPC分类号： C07D309/10

    CPC分类号： C07D309/12

    摘要： The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyranols by reacting 3-methylbut-3-en-1-ol (isoprenol) with the corresponding aldehydes in the presence of a strongly acidic cation exchanger. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with isovaleraldehyde.

    摘要翻译： 本发明涉及通过使3-甲基丁-3-烯-1-醇（异戊二烯）与相应的醛在强酸性阳离子交换剂存在下反应制备2-取代的4-羟基-4-甲基四氢吡喃醇的方法 。 具体地说，本发明涉及通过异戊二烯与异戊醛反应制备2-异丁基-4-羟基-4-甲基四氢吡喃的相应方法。

    Electrochemical preparation of sterically hindered amines
    9.
    发明授权
    Electrochemical preparation of sterically hindered amines 有权
    空间位阻胺的电化学制备

    公开(公告)号：US07863486B2

    公开(公告)日：2011-01-04

    申请号：US12306616

    申请日：2007-06-27

    申请人： Ulrich Griesbach ,  Siegfried R. Waldvogel ,  Itamar Michael Malkowsky ,  Joern Kulisch

    发明人： Ulrich Griesbach ,  Siegfried R. Waldvogel ,  Itamar Michael Malkowsky ,  Joern Kulisch

    IPC分类号： C07C209/30 ,  C25B3/04

    CPC分类号： C25B3/04 ,  C07C209/30 ,  C07C2601/14 ,  C07C211/35 ,  C07C211/40

    摘要： The present invention relates to a process for preparing an amine, which comprises the step cathodic reduction of a corresponding oxime derivative of the general formula (I) where R is C1-6-alkyl or C2-6-alkenyl which is optionally substituted by one or more substituents selected independently from the group consisting of phenyl, O—C1-6-alkyl, NH—C1-6-alkyl, N(C1-6-alkyl)2, OH and NH2; R1 is H; C1-6-alkyl or C(O)—C1-6-alkyl and A is a 5-, 6- or 7-membered hydrocarbon ring which is saturated or has a double bond and in which at least one CH2 group may, if appropriate, be replaced by —O—, —S— —NH—, —N═ or —N(C1-6-alkyl)- and which may optionally be substituted by one or more further substituents selected independently from the group consisting of phenyl, C1-6-alkyl, O—C1-6-alkyl, NH—C1-6-alkyl, N(C1-6-alkyl)2, OH and NH2; wherein, based on the ring carbon bearing the substituent R, the oxime derivative has an excess of the R or S form of at least 10%.

    摘要翻译： 本发明涉及一种制备胺的方法，其包括通式（I）的相应肟衍生物的步骤阴极还原，其中R是C 1-6 - 烷基或任选被一个取代基取代的C 2-6 - 烯基 或更多取代基独立地选自苯基，O-C 1-6 - 烷基，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，OH和NH 2; R1是H; C 1-6 - 烷基或C（O）-C 1-6 - 烷基，A是饱和或具有双键并且其中至少一个CH 2基团的5-，6-或7-元烃环，如果 适当地被-O - ， - S - NH - ， - N =或-N（C 1-6 - 烷基）取代，并且其可以任选地被一个或多个另外的取代基取代，所述取代基独立地选自苯基 ，C 1-6 - 烷基，O-C 1-6 - 烷基，NH-C 1-6 - 烷基，N（C 1-6 - 烷基）2，OH和NH 2; 其中，基于带有取代基R的环碳，肟衍生物具有至少10％的R或S形式的过量。

    Method for producing M-substituted phenylalkanols by means of isomerization
    10.
    发明授权
    Method for producing M-substituted phenylalkanols by means of isomerization 失效
    通过异构化制备M取代的苯基链烷醇的方法

    公开(公告)号：US08686193B2

    公开(公告)日：2014-04-01

    申请号：US13503488

    申请日：2010-10-19

    申请人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

    发明人： Andreas Lanver ,  Klaus Ebel ,  Karl Beck ,  Ralf Pelzer ,  Jörg Botzem ,  Ulrich Griesbach

    IPC分类号： C07C45/51 ,  C07C29/56 ,  C07C47/22 ,  A61K8/18

    CPC分类号： C07C29/56 ,  C07C45/29 ,  C11B9/0061 ,  C07C33/20 ,  C07C47/228

    摘要： The invention relates to a process for the preparation of m-substituted phenylalkanols of the formula (I) in which R1 is C1-C5-alkyl and R2, R3, R4 and R5, independently of one another, are hydrogen or methyl, wherein a p-substituted phenylalkanol of the formula (II) in which R1, R2, R3, R4 and R5 having the meanings given under formula (I), is isomerized in the presence of a Friedel-Crafts catalyst to give an m-substituted phenylalkanol of the formula (I). From the m-substituted phenylalkanols of the formula (I) it is possible to form, by oxidation or dehydrogenation, as products of value, the corresponding aldehydes, which are known as fragrances and aroma chemicals.

    摘要翻译： 本发明涉及一种制备式（I）的间位取代的苯基烷醇的方法，其中R 1为C 1 -C 5 - 烷基且R 2，R 3，R 4和R 5彼此独立地为氢或甲基，其中a 式（II）的对取代的苯基链烷醇，其中具有式（I）给出的含义的R 1，R 2，R 3，R 4和R 5在Friedel-Crafts催化剂存在下异构化得到m-取代的苯基烷醇 式（I）。 从式（I）的间位取代的苯基烷醇可以通过氧化或脱氢形成作为有价值的产物，相应的醛被称为香料和芳香化学品。