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    Handle system for deploying a prosthetic implant
    1.
    发明申请
    Handle system for deploying a prosthetic implant 审中-公开
    用于部署假体植入物的手柄系统

    公开(公告)号：US20070156224A1

    公开(公告)日：2007-07-05

    申请号：US11324902

    申请日：2006-01-04

    申请人： Iulian Cioanta ,  Cesar Rincon ,  Brian Wilkins ,  Rance Winkler

    发明人： Iulian Cioanta ,  Cesar Rincon ,  Brian Wilkins ,  Rance Winkler

    IPC分类号： A61F2/06

    CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2002/9517

    摘要： A handle system of a delivery catheter for the deployment of prosthetic implants includes a first stationary portion, at least one guide rail secured to the first stationary portion and extending generally longitudinally with the handle system, and a generally cylindrical second rotating portion rotably connected to the first stationary portion. A sheath mount is secured to an outer sheath of the delivery catheter, and includes one or more bearing surfaces to engage with at least one of the one or more guide rails. Rotation of the second rotating portion longitudinally displaces the sheath mount by interaction with the sheath mount. Interaction may be by internal thread of the rotating portion and external thread of the sheath mount, or alternately by rotating one or more drive screws by turning the rotating portion, the drive screws interacting with through holes in the sheath mount configured to receive and engage the drive screws.

    摘要翻译： 用于部署假体植入物的输送导管的手柄系统包括第一固定部分，固定到第一固定部分并且与手柄系统大致纵向延伸的至少一个导轨，以及可旋转地连接到第二固定部分的大致圆柱形的第二旋转部分 第一静止部分。 护套安装件被固定到输送导管的外护套上，并且包括一个或多个支承表面，以与一个或多个导轨中的至少一个接合。 第二旋转部分的旋转通过与护套安装件的相互作用纵向地移动护套安装座。 相互作用可以是旋转部分的内螺纹和护套安装件的外螺纹，或者通过转动旋转部分来旋转一个或多个驱动螺钉，驱动螺钉与护套安装件中的通孔相配合，用于接收和接合 驱动螺丝

    Deployment catheter for medical implant devices
    2.
    发明申请
    Deployment catheter for medical implant devices 审中-公开
    用于医疗植入装置的部署导管

    公开(公告)号：US20070179586A1

    公开(公告)日：2007-08-02

    申请号：US11343626

    申请日：2006-01-31

    申请人： Gus Aguirre ,  Iulian Cioanta ,  Duane Couri ,  Eamonn P. FitzGerald ,  Heather Ann Bartholf Harries

    发明人： Gus Aguirre ,  Iulian Cioanta ,  Duane Couri ,  Eamonn P. FitzGerald ,  Heather Ann Bartholf Harries

    IPC分类号： A61F2/06

    CPC分类号： A61F2/95 ,  A61F2002/9665 ,  A61F2250/0071

    摘要： In a delivery catheter, first and second pods cover one or more prosthetic implants located around a central core, and are connected with one another to move as a unit and to present a continuous outer surface. Two independent release links, each extending from a proximal region of the delivery catheter to an interface with the first and second pods, respectively, and operative to displace the first and second pod, respectively. Applying tension to the release links releases the associated pod, either by displacing it from over the implant or rupturing the exterior of the pod. A user-operable handle at a proximal end of the delivery catheter can activate either or both independent release links. Also provided according to the present invention is a method for the deployment of a prosthetic implant.

    摘要翻译： 在输送导管中，第一和第二荚覆盖位于中心芯周围的一个或多个假体植入物，并且彼此连接以作为单元移动并呈现连续的外表面。 两个独立的释放连接件，分别从输送导管的近侧区域延伸到与第一和第二荚的界面，并分别用于移位第一和第二荚。 将张力施加到释放环节释放相关的荚，通过将其从植入物上移位或破坏荚的外部。 在输送导管的近端处的用户可操作的手柄可以激活任一个或两个独立的释放连接。 根据本发明还提供了一种用于部署假体植入物的方法。

    Thermal treatment systems with enhanced tissue penetration depth using adjustable treatment pressures and related methods
    3.
    发明申请
    Thermal treatment systems with enhanced tissue penetration depth using adjustable treatment pressures and related methods 审中-公开
    使用可调治疗压力和相关方法增强组织穿透深度的热处理系统

    公开(公告)号：US20050192652A1

    公开(公告)日：2005-09-01

    申请号：US10788735

    申请日：2004-02-26

    申请人： Iulian Cioanta ,  Richard Klein

    发明人： Iulian Cioanta ,  Richard Klein

    IPC分类号： A61B17/00 ,  A61B18/04 ,  A61F7/00 ,  A61F7/12

    CPC分类号： A61F7/12 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2018/046 ,  A61F2007/0054

    摘要： Methods, systems and computer program products include pressure monitoring and pressure adjustment devices in closed loop systems which control and adjust the pressure in a closed loop system configured to circulate heated liquid to a treatment balloon and concurrently heats and exerts pressures onto targeted tissue. The systems and methods can adjust the pressure to account for the physiology of the subject and the operational losses due to material relaxation over the duration of the thermal treatment.

    摘要翻译： 方法，系统和计算机程序产品包括闭环系统中的压力监测和压力调节装置，其控制和调节闭环系统中的压力，所述闭环系统构造成将加热的液体循环到治疗球囊并同时加热并向目标组织施加压力。 系统和方法可以调节压力以解决受试者的生理学以及在热处理期间由于材料松弛引起的操作损失。

    Use of Pressure Waves for Stimulation, Proliferation, Differentiation and Post-Implantation Viability of Stem Cells
    4.
    发明申请
    Use of Pressure Waves for Stimulation, Proliferation, Differentiation and Post-Implantation Viability of Stem Cells 有权
    使用压力波刺激，增殖，分化和植入后的干细胞活力

    公开(公告)号：US20110087157A1

    公开(公告)日：2011-04-14

    申请号：US12900818

    申请日：2010-10-08

    申请人： Iulian Cioanta ,  Christopher M. Cashman

    发明人： Iulian Cioanta ,  Christopher M. Cashman

    IPC分类号： A61N7/00 ,  A61M37/00 ,  C12N13/00

    CPC分类号： C12N13/00 ,  A61N7/00

    摘要： Stem cells are proliferated with the application of acoustic pressure waves, including cambium cells of periosteum treated in-vivo with acoustic pressure waves. Following harvesting and viability assessment of in-vivo or in-vitro proliferated stem cells, acoustic pressure waves are applied to enhance in-vivo or in-vitro differentiation either before or after implantation of the stems cells to an organism. Acoustic pressure waves also stimulate an implantation site to enhance viability and to grow desired tissue.

    摘要翻译： 应用声压波，包括用声压波在体内处理骨膜的形成层，使干细胞增殖。 在体内或体外增殖干细胞的收获和活力评估之后，在将茎细胞植入生物体之前或之后，施加声压波以增强体内或体外分化。 声压波还刺激植入部位以增强生存力并生长所需组织。

    Catheters with suction capability and related methods and systems for obtaining biosamples in vivo
    6.
    发明申请
    Catheters with suction capability and related methods and systems for obtaining biosamples in vivo 审中-公开
    具有抽吸能力的导管和用于在体内获得生物样品的相关方法和系统

    公开(公告)号：US20050054994A1

    公开(公告)日：2005-03-10

    申请号：US10827741

    申请日：2004-04-19

    申请人： Iulian Cioanta ,  Richard Klein ,  Jacob Lazarovitz

    发明人： Iulian Cioanta ,  Richard Klein ,  Jacob Lazarovitz

    IPC分类号： A61B10/00 ,  A61B10/02 ,  A61F2/958 ,  A61M25/04 ,  A61B17/20 ,  A61M1/00

    CPC分类号： A61B10/02 ,  A61B10/0045 ,  A61B10/007 ,  A61M25/04 ,  A61M25/1002 ,  A61M25/1011

    摘要： Methods, systems, and computer program products for obtaining a sample in vivo and/or treating a subject include positioning an elongated transurethral catheter in the prostatic urethra of a subject, the catheter having a bladder anchoring balloon, at least one biosample entry port disposed axially away from the bladder anchoring balloon, and an axially extending biosample flow channel in fluid communication with the biosample entry port held internally in the catheter. The anchoring balloon is inflated to position the catheter so that the fluid entry port is proximate the prostatic urethra of the subject and prostatic fluid is suctioned from the prostatic urethra into the biosample entry port and into the biosample flow channel. The catheter can include a thermal treatment balloon and/or dilatation balloon and the suctioned sample can be obtained concurrently with, during, or proximate in time to the applied treatment. The catheter can be configured to allow urine to drain therethrough during the treatment/collection of the sample while keeping the urine isolated from the collected prostatic fluid sample.

    摘要翻译： 用于在体内获得样品和/或治疗受试者的方法，系统和计算机程序产品包括将细长的经尿道导管定位在受试者的前列腺尿道中，所述导管具有膀胱锚定球囊，至少一个生物样本入口端口 远离气囊锚定气囊，以及轴向延伸的生物样品流动通道，其与保持在导管内部的生物样品入口端口流体连通。 锚定球囊被充气以定位导管，使得流体进入端口靠近受试者的前列腺尿道，并且前列腺液体从前列腺尿道吸入生物样本入口并进入生物样本流动通道。 导管可以包括热处理球囊和/或扩张球囊，并且抽吸样品可以在施用的治疗时间期间，期间或接近时间获得。 导管可以被配置成允许尿液在样品的处理/收集期间从其中排出，同时保持尿液与收集的前列腺液体样品分离。

    Use of pressure waves for stimulation, proliferation, differentiation and post-implantation viability of stem cells
    7.
    发明授权
    Use of pressure waves for stimulation, proliferation, differentiation and post-implantation viability of stem cells 有权
    使用压力波刺激，增殖，分化和植入后干细胞的生存能力

    公开(公告)号：US08728809B2

    公开(公告)日：2014-05-20

    申请号：US12900818

    申请日：2010-10-08

    申请人： Iulian Cioanta ,  Christopher M. Cashman

    发明人： Iulian Cioanta ,  Christopher M. Cashman

    IPC分类号： C12N5/074

    CPC分类号： C12N13/00 ,  A61N7/00

    摘要： Stem cells are proliferated with the application of acoustic pressure waves, including cambium cells of periosteum treated in-vivo with acoustic pressure waves. Following harvesting and viability assessment of in-vivo or in-vitro proliferated stem cells, acoustic pressure waves are applied to enhance in-vivo or in-vitro differentiation either before or after implantation of the stems cells to an organism. Acoustic pressure waves also stimulate an implantation site to enhance viability and to grow desired tissue.

    摘要翻译： 应用声压波，包括用声压波在体内处理骨膜的形成层，使干细胞增殖。 在体内或体外增殖干细胞的收获和活力评估之后，在将茎细胞植入生物体之前或之后，施加声压波以增强体内或体外分化。 声压波还刺激植入部位以增强生存力并生长所需组织。

    Methods for treating the prostate and inhibiting obstruction of the prostatic urethra using biodegradable stents
    9.
    发明授权
    Methods for treating the prostate and inhibiting obstruction of the prostatic urethra using biodegradable stents 失效
    使用可生物降解的支架治疗前列腺和抑制前列腺尿道阻塞的方法

    公开(公告)号：US06682555B2

    公开(公告)日：2004-01-27

    申请号：US10011494

    申请日：2001-11-13

    申请人： Iulian Cioanta ,  Richard Barry Klein

    发明人： Iulian Cioanta ,  Richard Barry Klein

    IPC分类号： A61F206

    CPC分类号： A61B18/04 ,  A61B2017/00274 ,  A61B2017/22069 ,  A61B2018/00547 ,  A61B2018/046 ,  A61F7/123 ,  A61M31/00 ,  A61M2210/166

    摘要： Methods of treating the prostate include administering a thermal ablation therapy and inhibiting the obstruction or closure of the prostatic urethral opening by forming a biodegradable stent in situ in the subject such that the stent attaches to the walls of the prostatic urethra. A related method of treating BPH includes thermally treating or ablating localized tissue in the prostate with a treatment catheter and inserting flowable stent material via the treatment catheter into the prostate (either before, during, or after the thermal treatment), forming the flowable stent material so that it defines a stent that remains in position after removal of the treatment catheter to inhibit the closure of the urinary passage. Associated stents and catheters are included.

    摘要翻译： 治疗前列腺的方法包括施用热消融治疗并通过在受试者中原位形成可生物降解的支架来阻止前列腺尿道开口的阻塞或闭合，使得支架附着在前列腺尿道的壁上。 治疗BPH的相关方法包括用处理导管热处理或消融前列腺中的局部组织，并将可流动的支架材料经由治疗导管插入前列腺（在热处理之前，期间或之后），形成可流动的支架材料 使得其限定了在移除治疗导管以保持尿路闭合之后保持就位的支架。 包括相关的支架和导管。