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公开(公告)号：US09745328B2
公开(公告)日：2017-08-29
申请号：US14765556
申请日：2014-01-31
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Genesis M. Bacani , Wendy Eccles , Anne E. Fitzgerald , Steven D. Goldberg , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Alice Lee-Dutra , Jing Liu , Kelly J. McClure , Steven P. Meduna , Daniel J. Pippel , Mark D. Rosen , Zachary S. Sales
IPC: C07F7/08 , C07D491/107 , C07D491/08 , C07D405/12 , C07D403/14 , A61K31/422 , A61K31/55 , A61K31/506 , C07D403/10 , C07D237/20 , C07D409/12 , C07D413/10 , C07D241/20 , C07D241/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D487/04 , C07D405/14 , C07D413/14 , C07D213/73 , C07D401/04 , C07D235/10 , C07D401/10 , C07D417/10 , C07D471/04 , C07D487/08 , C07D263/48 , C07D491/10 , C07D498/04 , C07D209/08 , C07D277/62 , C07D285/12 , C07F5/02 , C07D495/10
CPC classification number: C07F7/0812 , C07D209/08 , C07D213/73 , C07D235/10 , C07D237/20 , C07D241/20 , C07D241/26 , C07D263/48 , C07D277/62 , C07D285/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10 , C07D491/107 , C07D495/10 , C07D498/04 , C07F5/025 , C07F7/08
Abstract: The present invention relates to compounds of Formula (I), or a form thereof wherein ring A1, R1, R2, R3, R3′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号：US20140221310A1
公开(公告)日：2014-08-07
申请号：US14169642
申请日：2014-01-31
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Wendy Eccles , Anne E. Fitzgerald , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Jing Liu , Neelakandha S. Mani , Kelly J. McClure , Steven P. Meduna , Mark D. Rosen
IPC: C07D241/20 , C07D403/12 , C07D413/12 , C07D405/12 , C07D409/14 , C07D491/113 , C07D241/26 , C07D487/04 , C07D213/73 , C07D498/04 , C07F7/18 , C07D401/12 , C07D403/14
CPC classification number: C07D498/04 , A61K31/4353 , A61K31/4985 , A61K31/5025 , C07D213/73 , C07D237/20 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/26 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/113 , C07D495/04 , C07D513/04 , C07F7/1804 , C07F7/188 , C07F7/1892
Abstract: The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, L and R2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
Abstract translation: 本发明涉及式（I）化合物或其形式，其中环A，R 1，L和R 2如本文所定义，可用作FLAP调节剂。 本发明还涉及包含式（I）化合物的药物组合物。 制备和使用式（I）化合物的方法也在本发明的范围内。
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公开(公告)号：US20140135311A1
公开(公告)日：2014-05-15
申请号：US14157671
申请日：2014-01-17
Applicant: Janssen Pharmaceutica NV
Inventor： Brett D. Allison , Bryan James Branstetter , J. Guy Breitenbucher , Michael D. Hack , Natalie A. Hawryluk , Alec D. Lebsack , Kelly J. McClure , Jeffrey E. Merit
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
Abstract translation: 描述了某些四氢嘧啶并氮杂化合物，其可用作TRPV1调节剂。 这样的化合物可以用于治疗由TRPV1介导的疾病状态，病症和状况的药物组合物和方法。 因此，可以施用化合物以治疗，例如疼痛，瘙痒，咳嗽，哮喘或炎症性肠病。
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公开(公告)号：US20170327514A1
公开(公告)日：2017-11-16
申请号：US15667420
申请日：2017-08-02
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Wendy Eccles , Anne E. Fitzgerald , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Jing Liu , Neelakandha S. Mani , Kelly J. McClure , Steven P. Meduna , Mark D. Rosen
IPC: C07D498/04 , C07D487/04 , C07D471/04
CPC classification number: C07D498/04 , A61K31/4353 , A61K31/4985 , A61K31/5025 , C07D213/73 , C07D237/20 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/26 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/113 , C07D495/04 , C07D513/04 , C07F7/1804 , C07F7/188 , C07F7/1892
Abstract: The present invention relates to compounds of Formula (I), or a form thereof wherein ring A, R1, L and R2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号：US20150368270A1
公开(公告)日：2015-12-24
申请号：US14765552
申请日：2014-01-31
Applicant: Wendy ECCLES , JANSSEN PHARMACEUTICA NV
Inventor： Wendy Eccles , Anne E. Fitzgerald , Michael D. Hack , Natalie A. Hawryluk , Willian M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Jing Liu , Neelakandha S. Mani , Kally J. McClure , Steven P. Meduna , Mark D. Rosen
IPC: C07D513/04 , C07D401/12 , C07D241/20 , C07D495/04 , C07F7/18 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/113 , C07D403/12 , C07D403/14
CPC classification number: C07D498/04 , A61K31/4353 , A61K31/4985 , A61K31/5025 , C07D213/73 , C07D237/20 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/26 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/113 , C07D495/04 , C07D513/04 , C07F7/1804 , C07F7/188 , C07F7/1892
Abstract: The present invention relates to compounds of Formula (I), or a form thereof wherein ring A, R1, L and R2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
Abstract translation: 本发明涉及式（I）化合物或其形式，其中环A，R 1，L和R 2如本文所定义，可用作FLAP调节剂。 本发明还涉及包含式（I）化合物的药物组合物。 制备和使用式（I）化合物的方法也在本发明的范围内。
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Patent Agency Ranking
公开(公告)号：US10047101B2
公开(公告)日：2018-08-14
申请号：US15667420
申请日：2017-08-02
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Wendy Eccles , Anne E. Fitzgerald , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Jing Liu , Neelakandha S. Mani , Kelly J. McClure , Steven P. Meduna , Mark D. Rosen
IPC: C07D498/04 , C07D487/04 , C07D471/04 , A61K31/5025 , A61K31/4353 , A61K31/4985
CPC classification number: C07D498/04 , A61K31/4353 , A61K31/4985 , A61K31/5025 , C07D213/73 , C07D237/20 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/26 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/113 , C07D495/04 , C07D513/04 , C07F7/1804 , C07F7/188 , C07F7/1892
Abstract: The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, L and R2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号：US09926333B2
公开(公告)日：2018-03-27
申请号：US14719476
申请日：2015-05-22
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Wendy Eccles , Anne E. Fitzgerald , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Jing Liu , Neelakandha S. Mani , Kelly J. McClure , Steven P. Meduna , Mark D. Rosen
IPC: A61K31/506 , C07D403/10 , C07D513/04 , C07D241/20 , C07D213/73 , C07D241/26 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D487/04 , C07D491/113 , C07D498/04 , C07F7/18 , C07D237/20 , C07D239/42 , C07D417/12 , C07D471/04 , C07D491/10 , C07D239/47 , C07D495/04
CPC classification number: C07D498/04 , A61K31/4353 , A61K31/4985 , A61K31/5025 , C07D213/73 , C07D237/20 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/26 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/113 , C07D495/04 , C07D513/04 , C07F7/1804 , C07F7/188 , C07F7/1892
Abstract: The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, L and R2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号：US09738649B2
公开(公告)日：2017-08-22
申请号：US15207805
申请日：2016-07-12
Applicant: Janssen Pharmaceutica NV
Inventor： Brett D. Allison , Bryan James Branstetter , J. Guy Breitenbucher , Michael D. Hack , Natalie A. Hawryluk , Alec D. Lebsack , Kelly J. McClure , Jeffrey E. Merit
IPC: A61K31/55 , C07D487/04
CPC classification number: C07D487/04
Abstract: Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.
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公开(公告)号：US20150259357A1
公开(公告)日：2015-09-17
申请号：US14728128
申请日：2015-06-02
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Genesis M. Bacani , Wendy Eccles , Anne E. Fitzgerald , Steven D. Goldberg , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Alice Lee-Dutra , Jing Liu , Kelly J. McClure , Steven P. Meduna , Daniel J. Pippel , Mark D. Rosen , Zachary S. Sales
IPC: C07D498/04 , C07D487/04 , C07D471/04
CPC classification number: C07F7/0812 , C07D209/08 , C07D213/73 , C07D235/10 , C07D237/20 , C07D241/20 , C07D241/26 , C07D263/48 , C07D277/62 , C07D285/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10 , C07D491/107 , C07D495/10 , C07D498/04 , C07F5/025 , C07F7/08
Abstract: The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, R2, R3, R3′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention
Abstract translation: 本发明涉及式（I）化合物或其形式，其中环A，R 1，R 2，R 3，R 3'，L，W和V如本文所定义，可用作FLAP调节剂。 本发明还涉及包含式（I）化合物的药物组合物。 制备和使用式（I）化合物的方法也在本发明的范围内
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公开(公告)号：US20150252008A1
公开(公告)日：2015-09-10
申请号：US14719476
申请日：2015-05-22
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： Wendy Eccles , Anne E. Fitzgerald , Michael D. Hack , Natalie A. Hawryluk , William M. Jones , John M. Keith , Paul Krawczuk , Alec D. Lebsack , Jing Liu , Neelakandha S. Mani , Kelly J. McClure , Steven P. Meduna , Mark D. Rosen
IPC: C07D241/20 , C07D403/12 , C07D413/12 , C07D405/12 , C07D409/14 , C07D239/42 , C07D239/47 , C07D241/26 , C07D487/04 , C07D213/73 , C07D471/04 , C07D498/04 , C07F7/18 , C07D491/113 , C07D417/12 , C07D513/04 , C07D401/12
CPC classification number: C07D498/04 , A61K31/4353 , A61K31/4985 , A61K31/5025 , C07D213/73 , C07D237/20 , C07D239/42 , C07D239/47 , C07D241/20 , C07D241/26 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/113 , C07D495/04 , C07D513/04 , C07F7/1804 , C07F7/188 , C07F7/1892
Abstract: The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, L and R2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
Abstract translation: 本发明涉及式（I）化合物或其形式，其中环A，R 1，L和R 2如本文所定义，可用作FLAP调节剂。 本发明还涉及包含式（I）化合物的药物组合物。 制备和使用式（I）化合物的方法也在本发明的范围内。
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