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公开(公告)号:US20170342076A1
公开(公告)日:2017-11-30
申请号:US15538910
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号: C07D487/04 , A61K31/4985
CPC分类号: C07D487/04 , A61K31/4985 , A61K45/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US20170362242A1
公开(公告)日:2017-12-21
申请号:US15538902
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , C07D519/00
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , A61P37/02 , C07D519/00
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号:US20170362243A1
公开(公告)日:2017-12-21
申请号:US15538925
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , SHILAN LIU
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , SHILAN LIU
IPC分类号: C07D487/04 , A61K31/4985
CPC分类号: C07D487/04 , A61K31/4985 , A61K45/06 , A61P3/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号:US20180079752A1
公开(公告)日:2018-03-22
申请号:US15578775
申请日:2016-05-31
申请人: ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
发明人: ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
IPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61P19/02
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US20180141962A1
公开(公告)日:2018-05-24
申请号:US15564349
申请日:2016-04-04
申请人: JIAN LIU , JOSEPH KOZLOWSKI , RONALD KIM , XIAOLEI GAO , SOBHANA BABU BOGA , YOUNONG YU , HAO WU , SHILAN LIU , CHUNDAO YANG , MERCK SHARP & DOHME CORP.
发明人: JIAN LIU , JOSEPH KOZLOWSKI , RONALD KIM , XIAOLEI GAO , SOBHANA BABU BOGA , YOUNONG YU , HAO WU , SHILAN LIU , CHUNDAO YANG
IPC分类号: C07D519/00 , A61P19/02
CPC分类号: C07D519/00 , A61P19/02
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein CH, R1, R1a, R1b, R2, R3, and the subscripts m1, m2, p, q, and t are as set forth herein. The present invention also provides pharmaceutical compositions comprising these compounds and their use in therapy. In Cparticular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated dis orders.
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公开(公告)号:US20150353570A1
公开(公告)日:2015-12-10
申请号:US14762954
申请日:2014-01-22
申请人: Hao WU , Ronald M. KIM , Jian LIU , Xiaolei GAO , Sobhana Babu BOGA , Deodialsingh GUIADEEN , Joseph KOZLOWSKI , Wensheng YU , Rajan ANAND , Younong YU , Oleg B. Selyutin , Ying-Duo GAO , Shilan LIU , Chundao YANG , Hongjian WANG , MERCK SHARP & DOHME CORP.
发明人: RONALD M. KIM , JIAN LIU , XIAOLEI GAO , SOBHANA BABU BOGA , DEODIALSINGH GUIADEEN , JOSEPH A. KOZLOWSKI , WENSHENG WU , RAJAN ANAND , YOUNONG YU , OLEG B. SELYUTIN , YING-DUO GAO , HAO WU , SHILAN LIU , CHUNDAO YANG , HONGJIAN WANG
IPC分类号: C07D491/048 , C07D471/04 , A61K45/06 , A61K31/5383 , C07D455/02 , A61K31/5365 , A61K31/497 , C07D498/04
CPC分类号: C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , Y02A50/411 , Y02A50/463
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要翻译: 本发明提供了根据式I的Bruton's酪氨酸激酶(Btk)抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。 特别地,本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。
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