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公开(公告)号:US20170342076A1
公开(公告)日:2017-11-30
申请号:US15538910
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号: C07D487/04 , A61K31/4985
CPC分类号: C07D487/04 , A61K31/4985 , A61K45/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US20170362242A1
公开(公告)日:2017-12-21
申请号:US15538902
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , C07D519/00
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , A61P37/02 , C07D519/00
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号:US20170240511A1
公开(公告)日:2017-08-24
申请号:US15517553
申请日:2015-10-08
申请人: Fez UJJAINWALLA , John Qiang TAN , Qun DANG , Christopher J. SINZ , Ming WANG , Jiaqiang CAI , Xiaoxing DU , Yili CHEN , MERCK SHARP & DOHME CORP.
发明人: FEZ UJJAINWALLA , JOHN QIANG TAN , QUN DANG , CHRISTOPHER J. SINZ , MING WANG , JIAQIANG CAI , XIAOXING DU , YILI CHEN
IPC分类号: C07D213/82 , C07D401/04
CPC分类号: C07D213/82 , A61P7/08 , C07D401/04
摘要: The present invention concerns compounds of formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号:US20170313718A1
公开(公告)日:2017-11-02
申请号:US15513854
申请日:2015-09-23
申请人: JIAQIANG CAI , ALEJANDRO CRESPO , JOHN DEBENHAM , XIAOXING DU , PING LIU , RONGQIANG LIU , CHRISTINA B. MADSEN-DUGGAN , WEIGUO QUAN , CHRISTOPHER SINZ , LIPING WANG
发明人: JIAQIANG CAI , ALEJANDRO CRESPO , JOHN DEBENHAM , XIAOXING DU , PING LIU , RONGQIANG LIU , CHRISTINA B. MADSEN-DUGGAN , WEIGUO QUAN , CHRISTOPHER SINZ , LIPING WANG
IPC分类号: C07D495/04 , C07D491/048
CPC分类号: C07D495/04 , A61P7/06 , C07D491/048
摘要: The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号:US20170226120A1
公开(公告)日:2017-08-10
申请号:US15514537
申请日:2015-09-23
申请人: JIAQIANG CAI , ALEJANDRO CRESPO , XIAOXING DU , BYRON GABRIEL DUBOIS , PING LIU , RONGQIANG LIU , WEIGUO QUAN , CHRISTOPHER SINZ , LIPING WANG
发明人: JIAQIANG CAI , ALEJANDRO CRESPO , XIAOXING DU , BYRON GABRIEL DUBOIS , PING LIU , RONGQIANG LIU , WEIGUO QUAN , CHRISTOPHER SINZ , LIPING WANG
IPC分类号: C07D491/048
CPC分类号: C07D491/048 , A61P7/06 , A61P9/10
摘要: The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号:US20170240513A1
公开(公告)日:2017-08-24
申请号:US15517550
申请日:2015-10-08
申请人: FEZ UJJAINWALLA , JOHN QIANG TAN , QUN DANG , CHRISTOPHER J. SINZ , MING WANG , YILI CHEN , JIAQIANG CAI , MERCK SHARP & DOHME CORP.
发明人: FEZ UJJAINWALLA , JOHN QIANG TAN , QUN DANG , CHRISTOPHER J. SINZ , MING WANG , YILI CHEN , JIAQIANG CAI
IPC分类号: C07D239/36 , C07D413/06
CPC分类号: C07D239/36 , A61P7/06 , C07D413/06
摘要: The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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