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公开(公告)号:US20180009828A1
公开(公告)日:2018-01-11
申请号:US15538957
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , XIAOLEI GAO , DEODIAL GUY GUIADEEN , SHILAN LIU , DAHAI WANG
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , XIAOLEI GAO , DEODIAL GUY GUIADEEN , SHILAN LIU , DAHAI WANG
IPC分类号: C07D519/00 , A61K31/4985
CPC分类号: C07D519/00 , A61K31/4985 , A61K45/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US20170342076A1
公开(公告)日:2017-11-30
申请号:US15538910
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号: C07D487/04 , A61K31/4985
CPC分类号: C07D487/04 , A61K31/4985 , A61K45/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US20170362243A1
公开(公告)日:2017-12-21
申请号:US15538925
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , SHILAN LIU
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , SHILAN LIU
IPC分类号: C07D487/04 , A61K31/4985
CPC分类号: C07D487/04 , A61K31/4985 , A61K45/06 , A61P3/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号:US10208047B2
公开(公告)日:2019-02-19
申请号:US15538910
申请日:2015-12-17
申请人: Jian Liu , Joseph A. Kozlowski , Brian M. Andresen , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
发明人: Jian Liu , Joseph A. Kozlowski , Brian M. Andresen , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号: C07D487/04 , A61K31/4985 , A61K45/06
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US20180079752A1
公开(公告)日:2018-03-22
申请号:US15578775
申请日:2016-05-31
申请人: ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
发明人: ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
IPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61P19/02
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号:US20170362242A1
公开(公告)日:2017-12-21
申请号:US15538902
申请日:2015-12-17
申请人: JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人: JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , C07D519/00
CPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , A61P37/02 , C07D519/00
摘要: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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