公开(公告)号：US20190175602A1

公开(公告)日：2019-06-13

申请号：US16326039

申请日：2017-08-14

申请人： Wensheng Yu ,  LING Tong ,  Joseph A. Koziowski ,  Craig: A Coburn ,  De-yi J. Yang ,  Deyou Sha ,  Jae-Hun. Kim ,  Michael Dwyer ,  Kartik M. Keertikar ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

发明人： Wensheng Yu ,  LING Tong ,  Joseph A. Koziowski ,  Craig: A Coburn ,  De-yi J. Yang ,  Deyou Sha ,  Jae-Hun. Kim ,  Michael Dwyer ,  Kartik M. Keertikar ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

IPC分类号： A61K31/5365 ,  C07D498/04 ,  A61P31/14 ,  A61K31/4995 ,  C07D519/00

摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetra-cyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：US20190185486A1

公开(公告)日：2019-06-20

申请号：US16326043

申请日：2017-08-14

申请人： Wensheng Yu ,  Joseph A. Kozlowski ,  Ling Tong ,  Craig A. Cobum ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

发明人： Wensheng Yu ,  Joseph A. Kozlowski ,  Ling Tong ,  Craig A. Cobum ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

IPC分类号： C07D498/04 ,  A61K31/5365 ,  A61K31/496 ,  A61K45/06 ,  A61P31/14

摘要： The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：US10208047B2

公开(公告)日：2019-02-19

申请号：US15538910

申请日：2015-12-17

申请人： Jian Liu ,  Joseph A. Kozlowski ,  Brian M. Andresen ,  Sobhana Babu Boga ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Jiaqiang Cai ,  Shilan Liu ,  Dahai Wang ,  Hao Wu ,  Chundao Yang

发明人： Jian Liu ,  Joseph A. Kozlowski ,  Brian M. Andresen ,  Sobhana Babu Boga ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Jiaqiang Cai ,  Shilan Liu ,  Dahai Wang ,  Hao Wu ,  Chundao Yang

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K45/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US20170362242A1

公开(公告)日：2017-12-21

申请号：US15538902

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  ABDUL-BASIT ALHASSAN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  WENSHENG YU ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  ABDUL-BASIT ALHASSAN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  WENSHENG YU ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  A61P37/02 ,  C07D519/00

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

公开(公告)号：US20170217940A1

公开(公告)日：2017-08-03

申请号：US15104584

申请日：2014-12-15

申请人： Joseph KOZLOWSKI ,  Craig COBURN ,  Wensheng YU ,  Bin HU ,  Bin ZHONG ,  Jinglai HAO ,  Dahai WANG ,  Tao JI ,  MERCL SHARP & DOHME CORP.

发明人： Joseph Kozlowski ,  Craig Coburn ,  Wensheng Yu ,  Ling Tong ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang ,  Tao Ji

IPC分类号： C07D405/14 ,  A61K31/4178 ,  A61K31/7072 ,  A61K45/06 ,  A61K31/4985

CPC分类号： C07D405/14 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4985 ,  A61K31/7072 ,  A61K45/06 ,  C07D493/04 ,  A61K2300/00

摘要： The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：US20060185426A1

公开(公告)日：2006-08-24

申请号：US11064742

申请日：2005-02-24

申请人： Alan Falkowski ,  Dahai Wang ,  Michael Bonne

发明人： Alan Falkowski ,  Dahai Wang ,  Michael Bonne

IPC分类号： G01M19/00

CPC分类号： F01L13/0005 ,  F01L1/344 ,  F01L13/0015 ,  F01L2800/00 ,  F01L2820/033 ,  F01M2250/60 ,  G01N11/08

摘要： A method and code for controlling the operation of a deactivatable valve lifter of an internal combustion engine includes determining an oil viscosity measure based upon an engine oil pressure achieved when the engine is operating at a warm engine idle operating condition; determining a minimum oil temperature for actuator operation based on a comparison of the oil viscosity measure with a stored value representing the oil's nominal viscosity; and enabling actuator operation when an instantaneous oil temperature is not less than the minimum oil temperature.

摘要翻译： 用于控制内燃机的可失活气门挺杆的操作的方法和代码包括基于当发动机在暖机发动机怠速运行状态下操作时实现的发动机机油压力来确定油粘度测量; 基于油粘度测量与表示油的标称粘度的存储值的比较，确定用于致动器操作的最低油温; 并且当瞬时油温不低于最低油温时启用致动器操作。

公开(公告)号：US20170342076A1

公开(公告)日：2017-11-30

申请号：US15538910

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  BRIAN M. ANDRESEN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  BRIAN M. ANDRESEN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K45/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US09504690B2

公开(公告)日：2016-11-29

申请号：US14005430

申请日：2012-03-16

申请人： Craig A. Coburn ,  Stuart B. Rosenblum ,  Joseph A. Kozlowski ,  Richard Soll ,  Hao Wu ,  Bin Hu ,  Bin Zhong ,  Dahai Wang ,  Changmao Shen ,  Fei Sun

发明人： Craig A. Coburn ,  Stuart B. Rosenblum ,  Joseph A. Kozlowski ,  Richard Soll ,  Hao Wu ,  Bin Hu ,  Bin Zhong ,  Dahai Wang ,  Changmao Shen ,  Fei Sun

IPC分类号： A61K31/535 ,  A61K31/5383 ,  C07D491/06 ,  C07D498/06 ,  A61K31/4178 ,  A61K45/06 ,  C07D493/06

CPC分类号： A61K31/5383 ,  A61K31/4178 ,  A61K45/06 ,  C07D491/06 ,  C07D493/06 ,  C07D498/06

摘要： The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.

公开(公告)号：US20070230448A1

公开(公告)日：2007-10-04

申请号：US11693148

申请日：2007-03-29

申请人： Dahai Wang

发明人： Dahai Wang

IPC分类号： H04L12/66

CPC分类号： H04L12/66

摘要： Embodiments of the present invention provide a method and a media gateway for realizing a packet-packet model session. According to an embodiment of the present invention, the media gateway determines whether the session meets the TrFO protocol. In the case that the session doesn't meet the TrFO protocol, the media gateway inserts a pair of back-to-back TCs, activates the pair of back-to-back TCs such that the pair of back-to-back TCs perform the TFO negotiation, thus making the pair of back-to-back TCs work in a pass-through mode. In the embodiments of the present invention, because it is possible to bypass the codec ability of the pair of back-to-back TCs, the voice quality deterioration introduced in the prior art due to adopting the codec conversion may be avoided.

摘要翻译： 本发明的实施例提供了一种用于实现分组分组模型会话的方法和媒体网关。 根据本发明的实施例，媒体网关确定会话是否满足TrFO协议。 在会话不符合TrFO协议的情况下，媒体网关插入一对背对背TC，激活一对背靠背TC，使得一对背对背TC执行 TFO协商，从而使一对背对背TC工作在直通模式。 在本发明的实施例中，由于可以绕过一对背靠背TC的编解码能力，可以避免由于采用编解码转换而在现有技术中引入的语音质量恶化。

公开(公告)号：US07107828B2

公开(公告)日：2006-09-19

申请号：US11064742

申请日：2005-02-24

申请人： Alan G. Falkowski ,  Dahai Wang ,  Michael A Bonne

发明人： Alan G. Falkowski ,  Dahai Wang ,  Michael A Bonne

IPC分类号： G01M19/00

CPC分类号： F01L13/0005 ,  F01L1/344 ,  F01L13/0015 ,  F01L2800/00 ,  F01L2820/033 ,  F01M2250/60 ,  G01N11/08

摘要： A method and code for controlling the operation of a deactivatable valve lifter of an internal combustion engine includes determining an oil viscosity measure based upon an engine oil pressure achieved when the engine is operating at a warm engine idle operating condition; determining a minimum oil temperature for actuator operation based on a comparison of the oil viscosity measure with a stored value representing the oil's nominal viscosity; and enabling actuator operation when an instantaneous oil temperature is not less than the minimum oil temperature.

摘要翻译： 用于控制内燃机的可失活气门挺杆的操作的方法和代码包括基于当发动机在暖机发动机怠速运行状态下操作时实现的发动机机油压力来确定油粘度测量; 基于油粘度测量与表示油的标称粘度的存储值的比较，确定用于致动器操作的最低油温; 并且当瞬时油温不低于最低油温时启用致动器操作。