公开(公告)号：US20230383037A1

公开(公告)日：2023-11-30

申请号：US18248565

申请日：2021-10-11

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Takumi TOMONO ,  Kohei MIYATA ,  Koichi SHIGENO

IPC: C08F222/38 ,  A61K47/36 ,  A61K47/34

CPC classification number: C08F222/38 ,  A61K47/36 ,  A61K47/34

Abstract: The object of the present invention is to provide an absorption enhancer capable of introducing high-molecular weight compounds into cells.
The object can be solved by a composition of the present invention comprising a polymer compound having a group represented by the following general formula (1) or the following general formula (2) at a side chain, and a compound to be administered with a molecular weight of 1,000 to 1,200,000.




wherein X1 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X2 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X3 is a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms or a benzyloxy group, a is an integer of 0 to 50, and * denotes a bonding site.




wherein X4 is a residue of neutral amino acid or ω-aminoalkanoic acid in which an end amino group and an end carboxyl group are removed, X5 is a residue of cell-penetrating peptide in which an end amino group and an end carboxyl group are removed, X6 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group or an oxycarbonyl group, b is an integer of 0 to 50, and * denotes a bonding site.

公开(公告)号：US20180016366A1

公开(公告)日：2018-01-18

申请号：US15547840

申请日：2016-02-23

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Kohta MOHRI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: C08F8/30 ,  C07K5/062 ,  A61K47/32

CPC classification number: C08F8/30 ,  A61K47/32 ,  C07K2/00 ,  C07K5/06026 ,  C08F220/06 ,  C08F220/56 ,  C08F226/02 ,  C08G81/00 ,  C08F2220/603

Abstract: A polymer compound has a group represented by Formula (1) or Formula (2) in a side chain. (In Formula (1), X1 represents a neutral amino acid residue or an ω-aminoalkanoic acid residue, X2 represents a membrane-permeable peptide residue, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, and a represents a number of from 1 to 50.) (In Formula (2), X4 represents a neutral amino acid residue or an ω-aminoalkanoic acid residue, X5 represents a membrane-permeable peptide residue, X6 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group, or a carboxyl group, and b represents a number of from 1 to 50.)

公开(公告)号：US20210268113A1

公开(公告)日：2021-09-02

申请号：US17258868

申请日：2019-07-11

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Masami UKAWA ,  Shunsuke TAKAHI ,  Kazunori FUKUSHIMA ,  Mio MUTO ,  Kohei MIYATA ,  Akiko TASAKI ,  Hotaru MATSUMOTO

IPC: A61K47/42 ,  C08F220/54 ,  A61K47/32 ,  C08B37/08 ,  A61K47/36 ,  A61K47/34 ,  C08G63/91

Abstract: The object of the present invention is to provide a technique for promoting membrane permeation of a drug, which is highly versatile and highly safe.
The object can be solved by a polymer compound having a molecular weight of 1000 or more, wherein the polymer compound has, at an end of a side chain, one arginine or a basic peptide of chain length of 2 to 6 containing one or more arginine, and comprises a guanidino group of 0.5 to 20 mmol/g, originating from arginine.

公开(公告)号：US20180044381A1

公开(公告)日：2018-02-15

申请号：US15547595

申请日：2016-02-23

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Kohta MOHRI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: C07K9/00 ,  A61K47/36 ,  A61K47/42

Abstract: A polysaccharide derivative has a partial structure represented by Formula (1) below. It is preferable that at least one of the amino acids that constitute X2 in Formula (1) below is a basic amino acid. (In the formula, X1 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a neutral amino acid or an ω-aminoalkanoic acid, X2 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a membrane-permeable peptide, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, a represents a number of 0 or 1, and b represents a number of from 0 to 50.)