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    Modified proteases that inhibit complement activation
    1.
    发明申请
    Modified proteases that inhibit complement activation 审中-公开
    抑制补体激活的修饰蛋白酶

    公开(公告)号：US20070093443A1

    公开(公告)日：2007-04-26

    申请号：US11584776

    申请日：2006-10-20

    申请人： Edwin Madison ,  Jack Nguyen ,  Sandra Ruggles ,  Christopher Thanos

    发明人： Edwin Madison ,  Jack Nguyen ,  Sandra Ruggles ,  Christopher Thanos

    IPC分类号： A61K48/00 ,  C12N15/09

    CPC分类号： A61K38/482 ,  A61K38/49 ,  C07K2319/00 ,  C12N9/6421 ,  C12N9/6424 ,  C12N9/6467 ,  C12Y304/21109

    摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.

    摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎性疾病和具有炎性成分的疾病，包括阿尔茨海默氏病和其他神经变性疾病。

    Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases
    3.
    发明申请
    Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases 审中-公开
    通过野生型和突变蛋白酶切割VEGF和VEGF受体

    公开(公告)号：US20060024289A1

    公开(公告)日：2006-02-02

    申请号：US11104111

    申请日：2005-04-12

    申请人： Sandra Ruggles ,  Jack Nguyen

    发明人： Sandra Ruggles ,  Jack Nguyen

    IPC分类号： C12N9/42 ,  A61K38/48 ,  C12N9/64

    CPC分类号： C12Q1/37 ,  A61K38/00 ,  A61K45/06 ,  C07K2319/50 ,  C12N9/6424 ,  C12N9/6467 ,  C12N9/6475 ,  C12Y304/21079 ,  C12Y304/21109 ,  G01N2500/00

    摘要： Disclosed herein are methods for creating and using mutein proteases with altered specificity for the target molecules they cleave. The invention further discloses methods of using wild-type and mutein granzyme B to target VEGFR proteins to treat diseases, such as cancer. Cleaving VEGFR at certain substrate sequences with wild-type and mutein granzyme B proteases is a method for treating pathologies associated with angiogenesis.

    摘要翻译： 本文公开了用于产生和使用对其分裂的靶分子具有特异性改变的突变蛋白酶的方法。 本发明还公开了使用野生型和突变蛋白颗粒酶B靶向VEGFR蛋白以治疗诸如癌症的疾病的方法。 用野生型和突变蛋白颗粒酶B蛋白酶切割某些底物序列的VEGFR是用于治疗与血管生成相关的病理学的方法。

    MODIFIED PROTEASES THAT INHIBIT COMPLEMENT ACTIVATION
    4.
    发明申请
    MODIFIED PROTEASES THAT INHIBIT COMPLEMENT ACTIVATION 有权
    改进的保护措施，禁止补充活动

    公开(公告)号：US20140242062A1

    公开(公告)日：2014-08-28

    申请号：US14275772

    申请日：2014-05-12

    申请人： Edwin L. Madison ,  Jack Nguyen ,  Sandra Waugh Ruggles ,  Christopher Thanos

    发明人： Edwin L. Madison ,  Jack Nguyen ,  Sandra Waugh Ruggles ,  Christopher Thanos

    IPC分类号： A61K38/48

    CPC分类号： A61K38/482 ,  A61K38/49 ,  C07K2319/00 ,  C12N9/6421 ,  C12N9/6424 ,  C12N9/6467 ,  C12Y304/21109

    摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.

    摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎症性疾病和具有炎性成分的疾病，包括阿尔茨海默病和其他神经变性疾病。

    Fast charging battery pack and methods to charge fast
    10.
    发明授权
    Fast charging battery pack and methods to charge fast 有权

    公开(公告)号：US10978887B2

    公开(公告)日：2021-04-13

    申请号：US16824070

    申请日：2020-03-19

    申请人： James Nguyen ,  Jack Nguyen

    发明人： James Nguyen ,  Jack Nguyen

    IPC分类号： H02J7/00 ,  B60L53/67 ,  B60L53/14 ,  H02J7/02

    摘要： A fast charging battery system and method for charging battery systems can be applied to most battery types in use for electric vehicles (EVs), electronic devices, and wireless electrical machines. The system could employ industry proven battery charger systems and off-the-shelf electrical components (e.g., contactors, relay switches, semiconductor parts, DC-DC converters, and the like) to keep cost and complexity low. The system provides for two or more charging ports in the electronic device, such as an EV, that may be able to receive and recognize a charging type, such as charging voltage, current and the like, and provide directed charging to multiple battery sub-packs that make up the entire battery. By charging sub-packs in parallel, the charge time can be substantially reduced.