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    PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction
    1.
    发明授权
    PGE-1 containing lyophilized liposomes for use in the treatment of erectile dysfunction 失效
    PGE-1含有用于治疗勃起功能障碍的冻干脂质体

    公开(公告)号：US5718917A

    公开(公告)日：1998-02-17

    申请号：US573408

    申请日：1995-12-15

    申请人： Jackie R. See

    发明人： Jackie R. See

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K31/557 ,  A61K31/5575 ,  A61P13/02 ,  A61P15/00

    CPC分类号： A61K31/5575 ,  A61K9/0034 ,  A61K9/127 ,  A61K9/1272

    摘要： A method for the treatment of erectile dysfunction comprises instilling intra meatally an aqueous solution containing prostaglandin-containing liposomes and a detergent for lysing the liposomes. A pharmaceutical composition for treating erectile dysfunction comprises a two-component system. The first component comprises a predetermined amount of lyophilized prostaglandin-containing liposomes. The second component comprises a predetermined volume of an aqueous solution containing a detergent, preferably PEG(9) octylphenyl ether, for lysing the liposomes. Dissolution of the lyophilized prostaglandin-containing liposomes yields a liquid composition suitable for application to the penis, preferably intra meatally, to effect erection.

    摘要翻译： 用于治疗勃起功能障碍的方法包括在肉内施用含有含前列腺素的脂质体的水溶液和用于裂解脂质体的洗涤剂。 用于治疗勃起功能障碍的药物组合物包括双组分体系。 第一组分包含预定量的含冻干前列腺素的脂质体。 第二组分包含预定体积的含有洗涤剂的水溶液，优选PEG（9）辛基苯基醚，用于裂解脂质体。 含有冻干的含前列腺素的脂质体的溶解产生适合于阴茎的液体组合物，优选在肉内进行勃起。

    Device and methods for monitoring the administration of a stem cell transplant
    2.
    发明授权
    Device and methods for monitoring the administration of a stem cell transplant 有权
    监测干细胞移植管理的装置和方法

    公开(公告)号：US08313477B2

    公开(公告)日：2012-11-20

    申请号：US13041307

    申请日：2011-03-04

    申请人： Jackie R. See ,  Carl J. Buczek ,  John W. Matthews

    发明人： Jackie R. See ,  Carl J. Buczek ,  John W. Matthews

    IPC分类号： A61M31/00

    CPC分类号： A61B5/4839 ,  A61B5/0073 ,  A61B5/0084

    摘要： A device and methods for the real-time monitoring of stem cells in a stem cell transplant. The device comprises a linear member and particle detection device configured to occupy the lumen of a catheter while the catheter is in place to administer a stem cell transplant to a delivery site in the body of a patient. Monitoring of the stem cells permits the device to provide signals to a computer processor for the determination of one or more characteristics of stem cells in the stem cell transplant.

    摘要翻译： 用于干细胞移植中干细胞的实时监测的装置和方法。 该装置包括线性构件和颗粒检测装置，其构造成在导管就位时占据导管的内腔，以将干细胞移植物施用于患者体内的递送部位。 监测干细胞允许装置向计算机处理器提供信号，以确定干细胞移植物中干细胞的一个或多个特征。

    Non-radioactively labeled microspheres and use of same to measure blood flow
    4.
    发明授权
    Non-radioactively labeled microspheres and use of same to measure blood flow 失效
    非放射性标记的微球和使用它们来测量血流量

    公开(公告)号：US4616658A

    公开(公告)日：1986-10-14

    申请号：US706151

    申请日：1985-02-27

    申请人： William Shell ,  Jackie R. See

    发明人： William Shell ,  Jackie R. See

    IPC分类号： A61D13/00 ,  A61B5/026 ,  A61B5/0275 ,  A61K49/00 ,  A61K51/12 ,  G01N33/58 ,  A61B5/02

    CPC分类号： A61B5/0275 ,  A61K49/0004 ,  A61K51/1255 ,  A61K2123/00 ,  Y10T436/13

    摘要： A safe and inexpensive method of measuring blood flow in experimental animals using non-radioactively labeled microspheres is provided. The microspheres may be comprised of a variety of materials, including latex and agarose, and may be labeled with colored dyes or by linkage to enzymes, plant enzymes being preferred because they do not occur naturally in an animal's system. After injection and circulation of the microspheres throughout the animal's system, blood flow to particular tissue may be measured by counting the number of microspheres in the tissue sample, the initial number of microspheres in the animal's blood stream having been measured shortly after injection. In the case of microspheres labeled with colored dyes, the spheres may be counted in tissue either after separation from the tissue or while still trapped in the tissue's capillaries. Techniques for separating the microspheres from blood and tissue are also provided.

    摘要翻译： 提供了一种使用非放射性标记微球测量实验动物血流量的安全且廉价的方法。 微球可以包括各种材料，包括胶乳和琼脂糖，并且可以用有色染料或通过连接酶进行标记，植物酶是优选的，因为它们不是天然存在于动物系统中。 在整个动物系统中注射和循环微球后，可以通过计数组织样品中的微球的数量，即在注射后不久测量的动物血流中的微球的初始数量来测量到特定组织的血流量。 在用有色染料标记的微球的情况下，球体可以在从组织分离之后或当仍被捕获在组织的毛细血管中时被计数在组织中。 还提供了从血液和组织中分离微球的技术。

    METHOD AND COMPOSITION FOR TREATING CYSTITIS
    5.
    发明申请
    METHOD AND COMPOSITION FOR TREATING CYSTITIS 有权
    用于治疗CYSTITIS的方法和组合物

    公开(公告)号：US20130251785A1

    公开(公告)日：2013-09-26

    申请号：US13802445

    申请日：2013-03-13

    申请人： Elliot B. Lander ,  Jackie R. See

    发明人： Elliot B. Lander ,  Jackie R. See

    IPC分类号： A61K9/127 ,  A61K31/726 ,  A61K31/728

    CPC分类号： A61K9/127 ,  A61K9/0034 ,  A61K31/726 ,  A61K31/727 ,  A61K31/728

    摘要： A medicament for treating cystitis and a method of treatment are provided. An agent to repair the damaged glycosaminoglycan (“GAG”) layers lining the urothelium, noted in cystitis, such as pentosan polysulfate, hyaluronic acid, chondroitin, etc., is provided in a liposomal carrier. Cystitis is treated by intravesically administering to a patient a therapeutically effective dose of the medicament.

    摘要翻译： 提供了一种治疗膀胱炎的药物和治疗方法。 在脂质体载体中提供了修复在膀胱炎中记载的尿路上皮的受损葡萄糖胺聚糖（“GAG”）层，例如戊聚糖多糖，透明质酸，软骨素等。 通过向患者施用治疗有效剂量的药物来治疗膀胱炎。

    Method for inducing a systemic immune response to an HIV antigen
    6.
    发明授权
    Method for inducing a systemic immune response to an HIV antigen 失效
    诱导HIV抗原的全身免疫应答的方法

    公开(公告)号：US06207185B1

    公开(公告)日：2001-03-27

    申请号：US08948568

    申请日：1997-10-10

    申请人： Jackie R. See ,  Darryl M. See

    发明人： Jackie R. See ,  Darryl M. See

    IPC分类号： A61K9127

    CPC分类号： A61K39/125 ,  A61K9/127 ,  A61K9/4891 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55555 ,  A61K2039/57 ,  C12N2740/16234 ,  C12N2770/32334 ,  Y10S436/829

    摘要： A method is provided for inducing a systemic immune response to an antigen selected from inactivated HIV I and HIV II antigens in a mammal. The method comprises orally administering lyophilized multilaminar liposomes containing the antigen. The liposomes have a size of from 20 nm to 20 microns. The antigen-containing liposomes are absorbed in the Peyer's patches of the gut. Sufficient antigen-containing liposomes are taken up by macrophages in the Peyer's patches to induce a systemic immune response to the antigen.

    摘要翻译： 提供了一种用于诱导哺乳动物中选自灭活的HIV I和HIV II抗原的抗原的全身免疫应答的方法。 该方法包括口服含有抗原的冻干多层脂质体。 脂质体具有20nm至20微米的尺寸。 含抗原的脂质体被吸收在肠道的派耶尔斑块中。 含有足够的含抗原的脂质体被淋巴细胞的巨噬细胞吸收，以诱导对抗原的全身免疫应答。

    Volumetric determination of a fluid
    9.
    发明授权
    Volumetric determination of a fluid 失效
    液体的体积测定

    公开(公告)号：US4811741A

    公开(公告)日：1989-03-14

    申请号：US899161

    申请日：1986-08-22

    申请人： William E. Shell ,  Jackie R. See

    发明人： William E. Shell ,  Jackie R. See

    IPC分类号： A61D13/00 ,  A61B5/026 ,  A61B5/0275 ,  A61K49/00 ,  A61K51/12 ,  G01N33/58 ,  A61B5/02

    CPC分类号： A61B5/0275 ,  A61K49/0004 ,  A61K51/1255 ,  A61K2123/00 ,  Y10T436/13

    摘要： A process for making a volumetric determination of the quantity of a fluid, such as a liquid, by evaluation of a small sample of that fluid. The method comprises labeling microspheres with a non-radioactive substance and introducing the labeled microspheres into a body of fluid for which a determination is to be made. The microspheres are allowed to disperse in the body of fluid. Thereafter, a sample of the fluid which is of know or measurable volume, is selected. The number of microspheres present in the sample is then determined, from which a calculation of the volumetric measurement of the fluid may be made. The process is also adaptable to measuring the flow rate of a moving stream of fluid, since volume is one of the parameters of flow rate, and is also adaptable to determine the percentages of fluid components present in a mixture thereof.

    摘要翻译： 通过评估该流体的小样品来进行流体（例如液体）的量的体积测定的方法。 该方法包括用非放射性物质标记微球，并将标记的微球引入要进行测定的液体中。 允许微球分散在体液中。 此后，选择具有已知或可测量体积的流体样品。 然后确定样品中存在的微球的数量，由此可以计算流体的体积测量值。 该方法还适于测量流动流动的流速，因为体积是流速参数之一，并且还适用于确定其混合物中存在的流体组分的百分比。

    Methods for treating female sexual dysfunction
    10.
    发明授权
    Methods for treating female sexual dysfunction 失效
    治疗女性性功能障碍的方法

    公开(公告)号：US06046240A

    公开(公告)日：2000-04-04

    申请号：US301023

    申请日：1999-04-28

    申请人： Jackie R. See

    发明人： Jackie R. See

    IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K9/127 ,  A61K9/19 ,  A61K31/20 ,  A61K31/557 ,  A61K47/38 ,  A61P15/00 ,  A61K31/19

    CPC分类号： A61K31/5575 ,  A61K31/20 ,  A61K9/0034 ,  A61K9/127 ,  A61K9/19

    摘要： A method for treating female sexual dysfunction or for female sexual enhancement comprises administering to the vagina a composition comprising a prostanoid compound having a vasodilating effect in a pharmaceutically acceptable vehicle. The amount of prostanoid compound administered ranges from about 0.05 mg to about 3 mg, and preferably from about 0.125 mg to about 1 mg. Preferably the prostanoid compound is prostaglandin E-1 and the pharmaceutically acceptable vehicle is methylcellulose.

    摘要翻译： 用于治疗女性性功能障碍或女性性增强的方法包括向药物可药用载体中向阴道施用包含具有血管扩张作用的前列腺素类化合物的组合物。 前列腺素类化合物的给药量为约0.05mg至约3mg，优选约0.125mg至约1mg。 前列腺素类化合物优选为前列腺素E-1，药学上可接受的载体为甲基纤维素。