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    Imidazoline derivatives having CB1-antagonistic activity
    3.
    发明申请
    Imidazoline derivatives having CB1-antagonistic activity 有权
    具有CB1拮抗活性的咪唑啉衍生物

    公开(公告)号：US20050187259A1

    公开(公告)日：2005-08-25

    申请号：US11058168

    申请日：2005-02-16

    申请人： Josephus Lange ,  Cornelis Kruse ,  Herman Van Stuivenberg

    发明人： Josephus Lange ,  Cornelis Kruse ,  Herman Van Stuivenberg

    IPC分类号： A61K31/4178 ,  A61K31/4439 ,  C07D233/26 ,  C07D43/02

    CPC分类号： C07D233/26

    摘要： The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazoline derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these imidazoline derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.

    摘要翻译： 本发明涉及1,2,4-三取代咪唑啉衍生物，制备这些化合物的方法，可用于合成所述咪唑啉衍生物的新中间体，制备这些中间体的方法，药物组合物 含有这些咪唑啉衍生物中的一种或多种作为活性成分，以及这些药物组合物用于治疗精神病和神经障碍的用途。 化合物具有通式（I），其中符号具有说明书中给出的含义。

    1 H-IMIDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
    4.
    发明申请
    1 H-IMIDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS 失效
    1 H-咪唑衍生物作为CANNABINOID受体调节剂

    公开(公告)号：US20070281974A1

    公开(公告)日：2007-12-06

    申请号：US11842657

    申请日：2007-08-21

    申请人： Josephus Lange ,  Cornelis Kruse ,  Herman Van Stuivenberg ,  Hiskias Keizer

    发明人： Josephus Lange ,  Cornelis Kruse ,  Herman Van Stuivenberg ,  Hiskias Keizer

    IPC分类号： A61K31/4178 ,  A61K31/4164 ,  A61K31/454 ,  A61P1/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P9/00

    CPC分类号： C07D233/90

    摘要： The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders in which cannabinoid receptors are involved. The compounds have the general formula (I) wherein R, R1—R4 and X have the meanings given in the specification.

    摘要翻译： 本发明涉及一组作为大麻素受体的调节剂的1H-咪唑衍生物，制备这些化合物的方法，可用于合成所述咪唑衍生物的新中间体，制备这些中间体的方法，药物 含有这些1H-咪唑衍生物中的一种或多种作为活性成分的组合物，以及这些药物组合物用于治疗涉及大麻素受体的精神病和神经障碍的用途。 化合物具有通式（I），其中R 1，R 1 -R 4和X具有说明书中给出的含义。

    1H-imidazole derivatives as cannabinoid CB2 receptor modulators
    6.
    发明申请
    1H-imidazole derivatives as cannabinoid CB2 receptor modulators 有权
    1H-咪唑衍生物作为大麻素CB2受体调节剂

    公开(公告)号：US20060194779A1

    公开(公告)日：2006-08-31

    申请号：US11353155

    申请日：2006-02-14

    申请人： Josephus Lange ,  Herman Van Stuivenberg ,  Bernard Van Vliet

    发明人： Josephus Lange ,  Herman Van Stuivenberg ,  Bernard Van Vliet

    IPC分类号： A61K31/55 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/4178 ,  C07D403/02

    CPC分类号： C07D403/02

    摘要： The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid CB2 receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which cannabinoid CB2 receptors are involved. The compounds have the general formula (I) wherein R1-R4 have the meanings given in the specification.

    摘要翻译： 本发明涉及一组1H-咪唑衍生物，其是大麻素CB 2受体的调节剂，制备这些化合物的方法，可用于合成所述咪唑衍生物的新型中间体，方法 用于制备这些中间体的药物组合物包含一种或多种这些1H-咪唑衍生物作为活性成分的药物组合物，以及这些药物组合物用于治疗大麻素CB 2 >受体。 化合物具有通式（I），其中R 1 -R 4具有说明书中给出的含义。

    1H-imidazole derivatives as cannabinoid receptor modulators
    7.
    发明申请
    1H-imidazole derivatives as cannabinoid receptor modulators 有权
    1H-咪唑衍生物作为大麻素受体调节剂

    公开(公告)号：US20050137197A1

    公开(公告)日：2005-06-23

    申请号：US10965155

    申请日：2004-10-15

    申请人： Josephus Lange ,  Cornelis Kruse ,  Herman Van Stuivenberg ,  Hiskias Keizer

    发明人： Josephus Lange ,  Cornelis Kruse ,  Herman Van Stuivenberg ,  Hiskias Keizer

    IPC分类号： C07D233/90 ,  A61K31/53 ,  A61K31/497 ,  A61K31/501 ,  C07D43/02

    CPC分类号： C07D233/90

    摘要： The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders in which cannabinoid receptors are involved. The compounds have the general formula (I) wherein R, R1-R4 and X have the meanings given in the specification.

    摘要翻译： 本发明涉及一组作为大麻素受体的调节剂的1H-咪唑衍生物，制备这些化合物的方法，可用于合成所述咪唑衍生物的新中间体，制备这些中间体的方法，药物 含有这些1H-咪唑衍生物中的一种或多种作为活性成分的组合物，以及这些药物组合物用于治疗涉及大麻素受体的精神病和神经障碍的用途。 化合物具有通式（I），其中R 1，R 1 -R 4和X具有说明书中给出的含义。