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公开(公告)号：US20100099623A1
公开(公告)日：2010-04-22
申请号：US12648960
申请日：2009-12-29
CPC分类号： C07K14/78
摘要： The present invention discloses collagen cross-linked in a micro to non-fibrillar form and at a high concentration. The cross-linked collagen gel has improved volume stability or persistence than collagen cross-linked at a neutral pH. Also disclosed are methods for preparing the inventive cross-linked collagen and using such for augmenting soft tissues in mammals.
摘要翻译： 本发明公开了以微细至非纤维形式和高浓度交联的胶原蛋白。 交联胶原蛋白凝胶比在中性pH下交联的胶原具有改善的体积稳定性或持久性。 还公开了制备本发明的交联胶原蛋白和用于增强哺乳动物中的软组织的方法。
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公开(公告)号：US08697044B2
公开(公告)日：2014-04-15
申请号：US12247175
申请日：2008-10-07
CPC分类号： A61L27/44 , A61L27/26 , A61L27/48 , A61L27/54 , A61L2300/204 , A61L2300/402 , A61L2400/06 , A61L2430/04 , A61L2430/34 , A61M5/002 , C08L89/06 , C08L5/08
摘要： The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.
摘要翻译： 本发明公开了一种交联透明质酸/胶原制剂，其具有改善的皮肤填充组合物和较高的持久性，而不仅仅是交联胶原蛋白或HA单独使用。 还公开了用于制备交联透明质酸/胶原制剂并用于增加哺乳动物中的软组织的方法。
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公开(公告)号：US20120164098A1
公开(公告)日：2012-06-28
申请号：US13415733
申请日：2012-03-08
CPC分类号： A61L27/44 , A61L27/26 , A61L27/48 , A61L27/54 , A61L2300/204 , A61L2300/402 , A61L2400/06 , A61L2430/04 , A61L2430/34 , A61M5/002 , C08L89/06 , C08L5/08
摘要： The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.
摘要翻译： 本发明公开了一种交联透明质酸/胶原制剂，其具有改善的皮肤填充组合物和较高的持久性，而不仅仅是交联胶原蛋白或HA单独使用。 还公开了用于制备交联透明质酸/胶原制剂并用于增加哺乳动物中的软组织的方法。
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公开(公告)号：US08703118B2
公开(公告)日：2014-04-22
申请号：US13415733
申请日：2012-03-08
CPC分类号： A61L27/44 , A61L27/26 , A61L27/48 , A61L27/54 , A61L2300/204 , A61L2300/402 , A61L2400/06 , A61L2430/04 , A61L2430/34 , A61M5/002 , C08L89/06 , C08L5/08
摘要： The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.
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公开(公告)号：US20100099624A1
公开(公告)日：2010-04-22
申请号：US12649020
申请日：2009-12-29
CPC分类号： C07K14/78
摘要： The present invention discloses collagen cross-linked in a micro to non-fibrillar form and at a high concentration. The cross-linked collagen gel has improved volume stability or persistence than collagen cross-linked at a neutral pH. Also disclosed are methods for preparing the inventive cross-linked collagen and using such for augmenting soft tissues in mammals.
摘要翻译： 本发明公开了以微细至非纤维形式和高浓度交联的胶原蛋白。 交联胶原蛋白凝胶比在中性pH下交联的胶原具有改善的体积稳定性或持久性。 还公开了制备本发明的交联胶原蛋白和用于增加哺乳动物中的软组织的方法。
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公开(公告)号：US20090093755A1
公开(公告)日：2009-04-09
申请号：US12247175
申请日：2008-10-07
CPC分类号： A61L27/44 , A61L27/26 , A61L27/48 , A61L27/54 , A61L2300/204 , A61L2300/402 , A61L2400/06 , A61L2430/04 , A61L2430/34 , A61M5/002 , C08L89/06 , C08L5/08
摘要： The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.
摘要翻译： 本发明公开了一种交联透明质酸/胶原制剂，其具有改善的皮肤填充组合物和较高的持久性，而不仅仅是交联胶原蛋白或HA单独使用。 还公开了用于制备交联透明质酸/胶原制剂并用于增加哺乳动物中的软组织的方法。
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公开(公告)号：US08338375B2
公开(公告)日：2012-12-25
申请号：US12649020
申请日：2009-12-29
IPC分类号： A61K8/65
CPC分类号： C07K14/78
摘要： The present invention discloses collagen cross-linked in a micro to non-fibrillar form and at a high concentration. The cross-linked collagen gel has improved volume stability or persistence than collagen cross-linked at a neutral pH. Also disclosed are methods for preparing the inventive cross-linked collagen and using such for augmenting soft tissues in mammals.
摘要翻译： 本发明公开了以微细至非纤维形式和高浓度交联的胶原蛋白。 交联胶原蛋白凝胶比在中性pH下交联的胶原具有改善的体积稳定性或持久性。 还公开了制备本发明的交联胶原蛋白和用于增加哺乳动物中的软组织的方法。
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公开(公告)号：US20080293637A1
公开(公告)日：2008-11-27
申请号：US12125337
申请日：2008-05-22
CPC分类号： C07K14/78
摘要： The present invention discloses collagen cross-linked in a micro to non-fibrillar form and at a high concentration. The cross-linked collagen gel has improved volume stability or persistence than collagen cross-linked at a neutral pH. Also disclosed are methods for preparing the inventive cross-linked collagen and using such for augmenting soft tissues in mammals.
摘要翻译： 本发明公开了以微细至非纤维形式和高浓度交联的胶原蛋白。 交联胶原蛋白凝胶比在中性pH下交联的胶原具有改善的体积稳定性或持久性。 还公开了制备本发明的交联胶原蛋白和用于增加哺乳动物中的软组织的方法。
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公开(公告)号：US5456693A
公开(公告)日：1995-10-10
申请号：US297271
申请日：1994-08-25
申请人： Stanley R. Conston , Gregory S. Dapper , Aileen L. Murphy , Jennifer Raeder-Devens , Ronald Yamamoto
发明人： Stanley R. Conston , Gregory S. Dapper , Aileen L. Murphy , Jennifer Raeder-Devens , Ronald Yamamoto
CPC分类号： A61L17/005 , A61B17/12022 , A61B17/12045 , A61B17/1219 , A61L17/08 , A61B2017/00004 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/434 , A61L2300/604 , A61L2430/36 , Y10S128/08
摘要： A bioresorbable and hemostatic plug for embolization made from a collagen piece is compressed so as to be longitudinally insertable into a tubular biological vessel such as a blood vessel to be occluded. The collagen piece is capable of expanding radially inside the vessel by absorbing fluid such as the blood and thereby providing mechanical fixation in and occlusion of the vessel. Two such collagen pieces may be used with a spacer of a different material in between. Different kinds of therapeutic agents can be bonded to or physically absorbed by the collagen pieces so as to be delivered to the site of occlusion.
摘要翻译： 由胶原片制成的用于栓塞的生物可吸收和止血塞被压缩，以便纵向插入诸如血管的管状生物容器中以被阻塞。 胶原片能够通过吸收诸如血液的液体而径向扩张，从而提供容器的机械固定和闭塞。 两个这样的胶原片可以与其间的不同材料的间隔物一起使用。 可以将不同种类的治疗剂与胶原片结合或物理吸收，以便被输送至闭塞部位。
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公开(公告)号：US5322648A
公开(公告)日：1994-06-21
申请号：US750079
申请日：1991-08-26
申请人： Gregory S. Dapper
发明人： Gregory S. Dapper
CPC分类号： A61L27/24 , A61F2/16 , B29C39/003 , B29C39/42 , B29D11/00038 , C08L1/284 , C08L89/06 , A61F2310/00365 , B29K2089/00 , B29K2901/12 , C08L71/02
摘要： A method is provided for fabricating a shaped article from aqueous collagen-containing materials. A dispersion containing collagen and a surfactant is cast upon a mold of thermoplastic material and dried by a ramped drying profile under controlled conditions of relative humidity and temperature. The controlled drying allows for initial renaturation of the collagen dispersion then drying at high humidity to form a product with minimal residual stress.
摘要翻译： 提供了一种从含水胶原材料制造成型制品的方法。 将包含胶原蛋白和表面活性剂的分散体浇铸在热塑性材料的模具上，并在相对湿度和温度的受控条件下通过倾斜的干燥曲线干燥。 受控干燥允许胶原分散体的初始复性，然后在高湿度下干燥以形成具有最小残余应力的产物。
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