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公开(公告)号：US20120136157A1
公开(公告)日：2012-05-31
申请号：US13365687
申请日：2012-02-03
申请人： Jacques Dumas , William J. Scott , Du-Shieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo L. Musza , Bernd Riedl
发明人： Jacques Dumas , William J. Scott , Du-Shieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo L. Musza , Bernd Riedl
IPC分类号： C07D213/81
CPC分类号： C07D213/79 , C07D213/81 , C07D213/89
摘要： This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
摘要翻译： 本发明涉及新的芳基脲及其合成方法。 本发明化合物可用于治疗（i）raf介导的疾病，例如癌症，（ii）p38介导的疾病如炎症和骨质疏松症，和（iii）VEGF介导的疾病如血管生成障碍。
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公开(公告)号：US09181188B2
公开(公告)日：2015-11-10
申请号：US13365687
申请日：2012-02-03
申请人： Jacques Dumas , William J. Scott , Du-Schieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo L. Musza , Bernd Riedl
发明人： Jacques Dumas , William J. Scott , Du-Schieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo L. Musza , Bernd Riedl
IPC分类号： C07D213/18 , C07D213/79 , C07D213/81 , C07D213/89
CPC分类号： C07D213/79 , C07D213/81 , C07D213/89
摘要： This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
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公开(公告)号：US08110587B2
公开(公告)日：2012-02-07
申请号：US10361859
申请日：2003-02-11
申请人： Jacques Dumas , William J. Scott , Bernd Riedl , Du-Schieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo Musza
发明人： Jacques Dumas , William J. Scott , Bernd Riedl , Du-Schieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo Musza
IPC分类号： A61K31/44 , C07D211/72 , C07D211/92
CPC分类号： C07D213/79 , C07D213/81 , C07D213/89
摘要： This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
摘要翻译： 本发明涉及新的芳基脲及其合成方法。 本发明化合物可用于治疗（i）raf介导的疾病，例如癌症，（ii）p38介导的疾病如炎症和骨质疏松症，和（iii）VEGF介导的疾病如血管生成障碍。
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公开(公告)号：US20120046290A1
公开(公告)日：2012-02-23
申请号：US11932548
申请日：2007-10-31
申请人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
IPC分类号： A61K31/42 , A61K31/428 , A61K31/422 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/5377 , C07D261/14 , C07D231/40 , A61K31/415 , A61P29/00 , A61P19/02 , A61P19/10 , A61P11/06 , A61P1/00 , A61P31/00 , A61K31/4439
CPC分类号： C07D231/40 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/428 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D261/14 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.
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5.发明申请OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS 有权作为RAF激酶抑制剂的OMEGA-CARBOXYARYL替代二苯醚公开(公告)号：US20120142742A1
公开(公告)日：2012-06-07
申请号：US13368812
申请日：2012-02-08
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
CPC分类号： C07C275/36 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D213/75 , C07D213/81 , C07D213/82 , C07D295/13 , C07D295/135 , C07D295/192 , C07D413/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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6.发明授权公开(公告)号：US07678811B2
公开(公告)日：2010-03-16
申请号：US11775457
申请日：2007-07-10
申请人： Jacques Dumas , William J. Scott , Bernd Riedl
发明人： Jacques Dumas , William J. Scott , Bernd Riedl
IPC分类号： C07D401/02 , A61K31/44 , A61K31/47
CPC分类号： C07D213/89 , C07D215/60 , C07D217/08
摘要： This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angogenesis disorders.
摘要翻译： 本发明涉及含有吡啶，喹啉或异喹啉官能团的脲化合物，其在氮杂原子处被氧化并且可用于治疗（i）raf介导的疾病，例如癌症，（ii）p38介导的疾病，例如 炎症和骨质疏松症，和（iii）VEGF介导的疾病，如血管发生障碍。
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7.发明申请Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas 审中-公开使用芳基和杂芳基取代的杂环脲抑制p38激酶活性公开(公告)号：US20080300281A1
公开(公告)日：2008-12-04
申请号：US12181032
申请日：2008-07-28
申请人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人： Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号： A61K31/4439 , A61K31/415 , A61K31/4427 , A61K31/381 , A61P19/02
CPC分类号： A61K31/381 , A61K31/415 , A61K31/4427 , A61K31/4439 , Y02A50/411
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗癌症以外的细胞因子介导的疾病和除了癌症以外的蛋白水解酶介导的疾病以及用于这种治疗的药物组合物中的用途。
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公开(公告)号：US20070244120A1
公开(公告)日：2007-10-18
申请号：US11768112
申请日：2007-06-25
申请人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人： Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号： A61K31/5377 , A61K31/09 , A61K31/136 , A61K31/381 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/426 , C07D401/12 , C07D231/10 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497
CPC分类号： C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译： 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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公开(公告)号：US08124630B2
公开(公告)日：2012-02-28
申请号：US09993647
申请日：2001-11-27
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Reina Natero
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Reina Natero
IPC分类号： A61K31/44
CPC分类号： C07C275/36 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D213/75 , C07D213/81 , C07D213/82 , C07D295/13 , C07D295/135 , C07D295/192 , C07D413/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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10.发明授权公开(公告)号：US08071616B2
公开(公告)日：2011-12-06
申请号：US12692845
申请日：2010-01-25
申请人： Jacques Dumas , William J. Scott , Bernd Riedl
发明人： Jacques Dumas , William J. Scott , Bernd Riedl
IPC分类号： C07D401/02 , A61K31/44 , A61K31/47
CPC分类号： C07D213/89 , C07D215/60 , C07D217/08
摘要： This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
摘要翻译： 本发明涉及含有吡啶，喹啉或异喹啉官能团的脲化合物，其在氮杂原子处被氧化并且可用于治疗（i）raf介导的疾病，例如癌症，（ii）p38介导的疾病，例如 炎症和骨质疏松症，和（iii）VEGF介导的疾病如血管生成障碍。
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