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1.
公开(公告)号:US20070244120A1
公开(公告)日:2007-10-18
申请号:US11768112
申请日:2007-06-25
申请人: Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人: Jacques Dumas , Uday Khire , Timothy Lowinger , Holger Paulsen , Bernd Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号: A61K31/5377 , A61K31/09 , A61K31/136 , A61K31/381 , A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/426 , C07D401/12 , C07D231/10 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497
CPC分类号: C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译: 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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公开(公告)号:US20120046290A1
公开(公告)日:2012-02-23
申请号:US11932548
申请日:2007-10-31
申请人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
发明人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
IPC分类号: A61K31/42 , A61K31/428 , A61K31/422 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/5377 , C07D261/14 , C07D231/40 , A61K31/415 , A61P29/00 , A61P19/02 , A61P19/10 , A61P11/06 , A61P1/00 , A61P31/00 , A61K31/4439
CPC分类号: C07D231/40 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/428 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D261/14 , Y02A50/411
摘要: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.
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3.INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS 失效
标题翻译: 使用ARYL和HETEROARYL取代的杂环类URAAS对RAF激酶的抑制作用公开(公告)号:US20080009527A1
公开(公告)日:2008-01-10
申请号:US11768533
申请日:2007-06-26
申请人: Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人: Jacques Dumas , Uday Khire , Timothy Lowinger , Bernard Riedl , William Scott , Roger Smith , Jill Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号: A61K31/4439 , A61K31/415 , A61P35/00 , C07D401/12 , C07D405/04 , C07D231/38 , A61K31/443
CPC分类号: C07D231/40 , C07D333/36 , C07D401/12 , C07D405/04
摘要: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se,
摘要翻译: 用raf激酶介导的肿瘤治疗方法,用取代的脲化合物和这些化合物本身,
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4.Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas 失效
标题翻译: 使用喹啉基,异喹啉基或吡啶基脲来抑制RAF激酶公开(公告)号:US20060019990A1
公开(公告)日:2006-01-26
申请号:US11158048
申请日:2005-06-22
申请人: Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
发明人: Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
IPC分类号: A61K31/4709 , A61K31/444 , C07D401/02
CPC分类号: C07D213/40
摘要: The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要翻译: 本发明涉及一组喹啉基,异喹啉基和吡啶基脲,它们在治疗raf介导的疾病中的用途,以及含有用于这种治疗的这些尿素的药物组合物。
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5.Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas 审中-公开
标题翻译: 使用芳基和杂芳基取代的杂环脲抑制p38激酶活性公开(公告)号:US20080300281A1
公开(公告)日:2008-12-04
申请号:US12181032
申请日:2008-07-28
申请人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号: A61K31/4439 , A61K31/415 , A61K31/4427 , A61K31/381 , A61P19/02
CPC分类号: A61K31/381 , A61K31/415 , A61K31/4427 , A61K31/4439 , Y02A50/411
摘要: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗癌症以外的细胞因子介导的疾病和除了癌症以外的蛋白水解酶介导的疾病以及用于这种治疗的药物组合物中的用途。
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6.omega-Carboxy Aryl Substituted Diphenyl Ureas As p38 Kinase Inhibitors 有权
标题翻译: ω-羧基芳基取代的二苯脲作为p38激酶抑制剂公开(公告)号:US20080027061A1
公开(公告)日:2008-01-31
申请号:US11845597
申请日:2007-08-27
申请人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
发明人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
IPC分类号: A61K31/535 , A61K31/17 , A61P19/02 , A61K31/495
CPC分类号: A61K31/5377 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要: This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗p38介导的疾病中的用途,以及用于此类治疗的药物组合物。
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7.Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinease Inhibitors 审中-公开
标题翻译: ω-羧酰基取代的二苯基脲作为Raf Kinease抑制剂公开(公告)号:US20080032979A1
公开(公告)日:2008-02-07
申请号:US11845595
申请日:2007-08-27
申请人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , Scott William , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reink Natero , Joel Renick , Robert Sibley
发明人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , Scott William , Roger Smith , Jill Wood , Mary-Katherine Monahan , Reink Natero , Joel Renick , Robert Sibley
IPC分类号: A61K31/4035 , A61K31/17 , A61K31/44 , A61K31/5377 , A61P35/00 , C07C275/28 , C07D209/48 , C07D213/62 , C07D413/12
CPC分类号: C07C275/36 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D209/50 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D295/073 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D295/192 , C07D401/12 , C07D413/12 , C07F7/1804
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
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8.Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas 失效
标题翻译: 使用芳基和杂芳基取代的杂环尿素抑制RAF激酶公开(公告)号:US07625915B2
公开(公告)日:2009-12-01
申请号:US11768533
申请日:2007-06-26
申请人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernard Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernard Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号: A61K31/415 , C07D231/38 , C07D403/12
CPC分类号: C07D231/40 , C07D333/36 , C07D401/12 , C07D405/04
摘要: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译: 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
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9.Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas 失效
标题翻译: 使用芳基和杂芳基取代的杂环尿素抑制RAF激酶公开(公告)号:US07329670B1
公开(公告)日:2008-02-12
申请号:US09472232
申请日:1999-12-27
申请人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernard Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
发明人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernard Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Aniko Redman , Robert Sibley
IPC分类号: C07D231/38 , C07D403/12 , A61K31/415
CPC分类号: C07D231/40 , C07D333/36 , C07D401/12 , C07D405/04
摘要: The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or heteroaryl moiety. The compounds inhibit raf kinase and are useful in the treatment of RAF kinase mediated diseases.
摘要翻译: 化合物是式A-NH-C(O)-NH-B的芳基和杂芳基取代的杂环脲,其中A是芳基或杂芳基取代的杂环基,B是芳基或杂芳基部分。 该化合物抑制raf激酶,并且可用于治疗RAF激酶介导的疾病。
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10.
公开(公告)号:US07351834B1
公开(公告)日:2008-04-01
申请号:US09889227
申请日:2000-01-12
申请人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
发明人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy Lowinger , William Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert Sibley
IPC分类号: C07D213/30 , A61K31/44
CPC分类号: C07D209/48 , C07C251/48 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/36 , C07C275/40 , C07C311/29 , C07C317/22 , C07D207/09 , C07D209/46 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/81 , C07D213/82 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D295/192 , C07D307/14 , C07D401/12
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
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