公开(公告)号：US20080132460A1

公开(公告)日：2008-06-05

申请号：US11871146

申请日：2007-10-11

申请人： Jaekyoon SHIN ,  Han-Woong Lee ,  Goo Taeg Oh

发明人： Jaekyoon SHIN ,  Han-Woong Lee ,  Goo Taeg Oh

IPC分类号： A61K31/70 ,  G01N33/53 ,  G01N33/574 ,  A01K67/00 ,  C12N5/06 ,  C12Q1/68 ,  C40B40/08 ,  A61P43/00

CPC分类号： C12Q1/6883 ,  A01K2217/075 ,  C07K14/4702 ,  C07K2319/60 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In particular the application discloses a method of detecting the formation of inclusion bodies in neurodegenerative diseases. The invention further relates to a method of screening for therapeutic agents that disperse the inclusions. Further, transgenic mice containing a mutation in the p62 gene and having a functionally disrupted p62 gene locus are also disclosed.

摘要翻译： 该应用揭示了p62在老龄化相关疾病中的作用，如肥胖发展，2型糖尿病，非酒精性脂肪肝，各种肿瘤，男性死亡率增高，细胞内包涵体命名为后遗症和氧化还原调节。 特别地，该申请公开了一种检测神经变性疾病中包涵体形成的方法。 本发明还涉及筛选分散夹杂物的治疗剂的方法。 此外，还公开了含有p62基因突变且具有功能性破坏的p62基因座的转基因小鼠。

公开(公告)号：US07435872B2

公开(公告)日：2008-10-14

申请号：US10438516

申请日：2003-05-14

申请人： Jaekyoon Shin ,  Han-Woong Lee ,  Goo Taeg Oh

发明人： Jaekyoon Shin ,  Han-Woong Lee ,  Goo Taeg Oh

IPC分类号： A01K67/00 ,  A01K67/027 ,  A01N63/00 ,  C12N15/00 ,  C12N15/63

CPC分类号： C12Q1/6883 ,  A01K2217/075 ,  C07K14/4702 ,  C07K2319/60 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In particular the application discloses a method of detecting the formation of inclusion bodies in neurodegenerative diseases. The invention further relates to a method of screening for therapeutic agents that disperse the inclusions. Further, transgenic mice containing a mutation in the p62 gene and having a functionally disrupted p62 gene locus are also disclosed.

摘要翻译： 该应用揭示了p62在老龄化相关疾病中的作用，如肥胖发展，2型糖尿病，非酒精性脂肪肝，各种肿瘤，男性死亡率增高，细胞内包涵体命名为后遗症和氧化还原调节。 特别地，该申请公开了一种检测神经变性疾病中包涵体形成的方法。 本发明还涉及筛选分散夹杂物的治疗剂的方法。 此外，还公开了含有p62基因突变且具有功能性破坏的p62基因座的转基因小鼠。

公开(公告)号：US07534456B2

公开(公告)日：2009-05-19

申请号：US11802527

申请日：2007-05-23

申请人： Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Soon Ja Choi ,  Jung Hee Kim ,  Goo Taeg Oh ,  Jung Joo Hong ,  Seong Kyu Park ,  Woo Namkung

发明人： Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Soon Ja Choi ,  Jung Hee Kim ,  Goo Taeg Oh ,  Jung Joo Hong ,  Seong Kyu Park ,  Woo Namkung

IPC分类号： A01N65/00

CPC分类号： A61K36/532 ,  A23L33/105 ,  A23L33/11

摘要： This invention includes a composition of Agastache rugosa and tilianin obtained by separation-purification for anti-inflammation and anti-atherosclerosis, and more particularly, an extract of Agastache rugosa and tilianin obtained therefrom by separation-purification which are effective in preventing and treating not only inflammatory diseases but also atherosclerosis related to inflammatory responses and disease in the circulatory system caused by atherosclerosis because they are excellent in inhibiting the activity of complement systems as a factor of inflammatory responses, the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecular-1 (VCAM-1), and the production of nitric oxide (NO). They can also significantly reduce the development of atherosclerosis due to the inflammatory response.

摘要翻译： 本发明包括通过用于抗炎和抗动脉粥样硬化的分离纯化获得的藿香粗提物和斜霉素的组合物，更具体地，通过分离纯化从其获得的藿香提取物和斜霉素提取物，其不仅有效预防和治疗 炎症性疾病，而且与由动脉粥样硬化引起的循环系统中的炎性反应和疾病有关的动脉粥样硬化，因为它们作为炎症反应因子抑制补体系统的活性，细胞间粘附分子-1（ICAM-1）和 血管细胞粘附分子-1（VCAM-1）和一氧化氮（NO）的产生。 它们还可以显着减少由于炎症反应引起的动脉粥样硬化的发展。