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公开(公告)号：US20110015902A1
公开(公告)日：2011-01-20
申请号：US12891801
申请日：2010-09-27
申请人： James Chih CHENG , Raj Jayachandran , Ching-Hung Chuang , Yiping Xie , Yuan Wang , Tau Tyan , Leonard Anthony Shaner , Yu-Kan Hu
发明人： James Chih CHENG , Raj Jayachandran , Ching-Hung Chuang , Yiping Xie , Yuan Wang , Tau Tyan , Leonard Anthony Shaner , Yu-Kan Hu
CPC分类号： B62D25/08 , B60Y2304/00 , B62D21/152 , B62D65/00 , F16F7/128 , Y02T10/82
摘要： A method for optimizing a twelve-cornered strengthening member comprises: modeling a vehicle assembly including a strengthening member having a twelve-cornered cross section; parameterizing a geometry of the strengthening member with a plurality of control parameters; defining a design of experiment using the plurality of control parameters; modeling a vehicle using the vehicle assembly; simulating a frontal impact event with the vehicle; generating a response surface based on the frontal impact event; and determining a set of optimized control parameters for the strengthening member based on the response surface.
摘要翻译： 一种用于优化十二角加固构件的方法包括：对包括具有十二角横截面的加强构件的车辆组件进行建模; 用多个控制参数对加固构件的几何形状进行参数化; 使用所述多个控制参数来定义实验设计; 使用车辆组件对车辆进行建模; 模拟与车辆的正面碰撞事件; 基于正面碰撞事件产生响应面; 以及基于所述响应面确定所述加强构件的优化控制参数的集合。
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公开(公告)号：US09533710B2
公开(公告)日：2017-01-03
申请号：US12891801
申请日：2010-09-27
申请人： James Chih Cheng , Raj Jayachandran , Ching-Hung Chuang , Yiping Xie , Yuan Wang , Tau Tyan , Leonard Anthony Shaner , Yu-Kan Hu
发明人： James Chih Cheng , Raj Jayachandran , Ching-Hung Chuang , Yiping Xie , Yuan Wang , Tau Tyan , Leonard Anthony Shaner , Yu-Kan Hu
CPC分类号： B62D25/08 , B60Y2304/00 , B62D21/152 , B62D65/00 , F16F7/128 , Y02T10/82
摘要： A method for optimizing a twelve-cornered strengthening member comprises: modeling a vehicle assembly including a strengthening member having a twelve-cornered cross section; parameterizing a geometry of the strengthening member with a plurality of control parameters; defining a design of experiment using the plurality of control parameters; modeling a vehicle using the vehicle assembly; simulating a frontal impact event with the vehicle; generating a response surface based on the frontal impact event; and determining a set of optimized control parameters for the strengthening member based on the response surface.
摘要翻译： 一种用于优化十二角加固构件的方法包括：对包括具有十二角横截面的加强构件的车辆组件进行建模; 用多个控制参数对加固构件的几何形状进行参数化; 使用所述多个控制参数来定义实验设计; 使用车辆组件对车辆进行建模; 模拟与车辆的正面碰撞事件; 基于正面碰撞事件产生响应面; 以及基于所述响应面确定所述加强构件的优化控制参数的集合。
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3.发明授权Isolated nucleic acid molecule encoding a variant human eukaryotic Intiation Factor 4E protein 有权编码变体人真核起始因子4E蛋白的分离的核酸分子公开(公告)号：US06596854B2
公开(公告)日：2003-07-22
申请号：US09855747
申请日：2001-04-14
IPC分类号： C12N1512
CPC分类号： C07K14/4705
摘要： The invention provides a method of purifying human eIF-4E protein and amino acid sequence variants thereof having altered binding affinity for capped RNA. Using the described purification, amino acid sequence variants can readily be expressed, purified and tested. Both lowered and enhanced binding affinity variants are useful for modifying protein expression levels in vivo and in vitro.
摘要翻译： 本发明提供了纯化具有改变的对封端RNA的结合亲和力的人eIF-4E蛋白质及其氨基酸序列变体的方法。 使用所述纯化，氨基酸序列变体可以容易地进行表达，纯化和测试。 降低和增强的结合亲和力变体都可用于体内和体外修饰蛋白质表达水平。
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4.发明授权Purified eukaryotic-initiation factor 4E having altered RNA binding affinity 失效具有改变的RNA结合亲和力的纯化的真核起始因子4E公开(公告)号：US06232442B1
公开(公告)日：2001-05-15
申请号：US09465615
申请日：1999-12-17
IPC分类号： C07K1447
CPC分类号： C07K14/4705
摘要： The invention provides a method of purifying human eIF-4E protein and amino acid sequence variants thereof having altered binding affinity for capped RNA. Using the described purification, amino acid sequence variants can readily be expressed, purified and tested. Both lowered and enhanced binding affinity variants are useful for modifying protein expression levels in vivo and in vitro.
摘要翻译： 本发明提供了纯化具有改变的对封端RNA的结合亲和力的人eIF-4E蛋白质及其氨基酸序列变体的方法。 使用所述纯化，氨基酸序列变体可以容易地进行表达，纯化和测试。 降低和增强的结合亲和力变体都可用于体内和体外修饰蛋白质表达水平。
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