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公开(公告)号：US07097853B1
公开(公告)日：2006-08-29
申请号：US08968519
申请日：1997-11-12
IPC分类号： A61M37/00
CPC分类号： A61K9/7053 , A61K9/7061 , C08F290/04 , C09J155/005
摘要： A transdermal drug delivery device involving a macromonomer-containing acrylate or methacrylate copolymer, a softener, and a drug. Also a pressure sensitive skin adhesive involving a macromonomer containing acrylate or methacrylate copolymer and a softener.
摘要翻译： 涉及含有大分子单体的丙烯酸酯或甲基丙烯酸酯共聚物，软化剂和药物的透皮药物递送装置。 也是涉及包含丙烯酸酯或甲基丙烯酸酯共聚物和软化剂的大分子单体的压敏皮肤粘合剂。
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公开(公告)号：US09861580B2
公开(公告)日：2018-01-09
申请号：US13001630
申请日：2009-06-22
IPC分类号： B05D1/28 , A61K9/14 , A61K9/00 , A61K31/137
CPC分类号： A61K9/143 , A61K9/0075 , A61K9/146 , A61K31/137
摘要： A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising: providing a plurality of media particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; mixing the plurality of media particles with the active ingredient particles, both of which are in dry form, to provide active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and separating the plurality of media particles from the active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces is disclosed.
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公开(公告)号：US4931282A
公开(公告)日：1990-06-05
申请号：US125377
申请日：1987-11-25
申请人： Robert A. Asmus , Daniel C. Duan
发明人： Robert A. Asmus , Daniel C. Duan
CPC分类号： A61L15/58 , A61L24/0015 , A61L24/06 , A61L2300/106 , A61L2300/406 , Y10S526/931
摘要： A pressure-sensitive medical sealant composition comprising (a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; (b) a plasticizer; and (c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.
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公开(公告)号：US20110104362A1
公开(公告)日：2011-05-05
申请号：US13001630
申请日：2009-06-22
IPC分类号： A61K9/14
CPC分类号： A61K9/143 , A61K9/0075 , A61K9/146 , A61K31/137
摘要： A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising: providing a plurality of media particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; mixing the plurality of media particles with the active ingredient particles, both of which are in dry form, to provide active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and separating the plurality of media particles from the active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces is disclosed.
摘要翻译： 制备具有沉积在颗粒表面上的表面改性纳米颗粒的活性药物成分颗粒的方法，所述方法包括：提供多个介质颗粒，所述介质颗粒具有沉积在表面上的表面改性纳米颗粒的表面; 将多个介质颗粒与活性成分颗粒混合，两者均为干燥形式，以提供活性成分颗粒，其表面具有沉积在表面上的表面改性纳米颗粒; 并且公开了将多个介质颗粒与具有表面改性的纳米颗粒沉积在表面上的具有表面的活性成分颗粒分离。
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公开(公告)号：US6126919A
公开(公告)日：2000-10-03
申请号：US797803
申请日：1997-02-07
申请人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
发明人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
CPC分类号： A61K9/0075 , A61K47/482 , A61K9/008 , A61K9/1647
摘要： Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula --[X--R.sup.1 --C(O)]-- wherein each R.sup.1 is an independently selected organic group that links the --X-- group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
摘要翻译： 方法，化合物和利用生物相容性聚合物递送药物的药物制剂，特别是用于增溶，稳定和/或从局部，可植入和吸入系统中持续释放药物。 许多方法，化合物和药物制剂特别适用于口服和/或鼻吸入并使用下式的聚合物 - [X-R 1 -C（O）] - ，其中每个R 1是独立选择的有机基团，其连接 -X-基团，并且每个X独立地为氧，硫或链状氮。
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6.发明授权Pressure-sensitive poly(n-vinyl lactam) adhesive composition and skin covering articles using same 失效压敏聚（N-乙烯基内酰胺）粘合剂组合物和使用其的皮肤覆盖物品
公开(公告)号：US5389376A
公开(公告)日：1995-02-14
申请号：US139516
申请日：1993-10-15
IPC分类号： A61B5/0408 , A61K9/70 , A61L15/58 , A61N1/30 , C08F20/26 , C08F20/52 , C08F26/10 , C08F220/28 , C08F220/56 , C08F226/10 , C09J137/00 , C09J139/04 , H01R4/04 , A61F13/02
CPC分类号： A61K9/703 , A61K9/7053 , A61L15/58 , C09J139/04 , H01R4/04 , H01R2201/12 , Y10S522/912 , Y10S526/931
摘要： A hydrophilic, pressure-sensitive adhesive composition prepared by irradiating solid poly(N-vinyl lactam) with ionizing radiation to crosslink the poly(N-vinyl lactam) and thereafter mixing the radiation-crosslinked poly(N-vinyl lactam) with essentially unirradiated plasticizer in an amount sufficient to form a cohesive, pressure-sensitive adhesive composition. The composition is useful as a biomedical adhesive for transmitting or receiving electrical signals as a component of a biomedical electrode. The composition is also useful as a drug delivery device to deliver pharmaceuticals or other active ingredients to or through mammalian skin. The composition is also useful as a component in a skin covering for protecting mammalian skin or mammalian skin openings with antimicrobial agents. A method of preparation of the composition is also disclosed.
摘要翻译： 通过用电离辐射照射固体聚（N-乙烯基内酰胺）以交联聚（N-乙烯基内酰胺），然后将辐射交联的聚（N-乙烯基内酰胺）与基本上未照射的增塑剂混合而制备的亲水性压敏粘合剂组合物 其量足以形成粘合的压敏粘合剂组合物。 该组合物可用作生物医学粘合剂，用于作为生物医学电极的组分传输或接收电信号。 组合物还可用作药物递送装置，以将药物或其它活性成分递送至哺乳动物皮肤或通过哺乳动物皮肤。 组合物还可用作皮肤覆盖物中用于用抗微生物剂保护哺乳动物皮肤或哺乳动物皮肤开口的组分。 还公开了组合物的制备方法。
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公开(公告)号：US5225473A
公开(公告)日：1993-07-06
申请号：US866207
申请日：1992-04-09
申请人： Daniel C. Duan
发明人： Daniel C. Duan
IPC分类号： A61B5/0408 , A61K9/70 , A61L15/20 , A61L15/58 , A61L15/60 , C08F226/06
CPC分类号： A61K9/7053 , A61B5/04087 , A61K9/7061 , A61L15/20 , A61L15/58 , A61L15/60 , C08F226/06
摘要： Hydrophilic, cohesive, pressure-sensitive adhesive compositions are provided comprising a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups, and/or methallyl groups, which groups are bonded to nitrogen or oxygen atoms, and b) a plasticizer for the copolymer wherein the amount of the multi-ethylenically unsaturated compound and the plasticizer are present in amounts sufficient to render the polymeric matrix cohesive, swellable and pressure-sensitive adhesive. These compositions can also be used as adhesives for biomedical electrodes and transdermal drug delivery systems.
摘要翻译： 提供亲水性，粘性的压敏粘合剂组合物，其包含a）由N-乙烯基内酰胺单体和多烯键式不饱和化合物制成的交联的可溶胀聚合物基质，其中乙烯基为乙烯基，烯丙基和/或 甲基烯丙基，这些基团与氮或氧原子键合，和b）共聚物的增塑剂，其中多烯属不饱和化合物和增塑剂的量以足以使聚合物基体粘合，可溶胀和压力 - 敏感胶。 这些组合物也可以用作生物医学电极和透皮药物递送系统的粘合剂。
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公开(公告)号：US20080287858A1
公开(公告)日：2008-11-20
申请号：US12090422
申请日：2006-11-16
申请人： Daniel C. Duan
发明人： Daniel C. Duan
IPC分类号： A61B18/18
CPC分类号： A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： A method of treating a patient with a microneedle array having an active agent disposed on at least a portion of one or more of the microneedles, wherein the array with active agent is characterized by a first optical response when probed with a selected incident light spectrum. The array with active agent is applied to a skin surface, optionally allowed to remain on the skin surface for a specified time, and removed. The used array is probed with the selected incident light spectrum, a second optical response is sensed, and the difference between the first optical response and the second optical response is determined and compared to a predetermined threshold value.
摘要翻译： 一种用微针阵列治疗患者的方法，所述微针阵列具有设置在一个或多个微针的至少一部分上的活性剂，其中具有活性剂的阵列的特征在于用选定的入射光谱探测时的第一光学响应。 将具有活性剂的阵列施用于皮肤表面，任选地允许在皮肤表面上保持指定的时间并除去。 使用所选择的入射光谱探测所使用的阵列，感测第二光学响应，并且确定第一光学响应和第二光学响应之间的差异并将其与预定阈值进行比较。
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公开(公告)号：US20080262416A1
公开(公告)日：2008-10-23
申请号：US12089551
申请日：2006-11-17
申请人： Daniel C. Duan , Peter R. Johnson
发明人： Daniel C. Duan , Peter R. Johnson
CPC分类号： B81C1/0038 , A61K9/0021 , A61K47/26 , A61K47/32 , A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061 , B81B2201/055
摘要： A microneedle array having a substrate and a plurality of microneedles extending out from the substrate with a multi-phase matrix coating on at least a portion of the microneedle surface of the microneedle array. The multi-phase matrix coating comprises an active substance and has a first solid phase and a liquid phase. The first solid phase comprises a water-soluble polymer. Also, a method of providing an active substance- containing matrix coating on a microneedle array in which a water-soluble polymer is applied to the microneedle surface of the array to form a dried coating of water-soluble polymer. A coating solution comprising an active substance, a liquid capable of phase separating from the water-soluble polymer, and a carrier fluid is prepared and applied to the dried coating of water-soluble polymer. At least a portion of the carrier fluid is removed from the array.
摘要翻译： 一种微针阵列，其具有基底和多个微针，所述微针在所述微针阵列的所述微针表面的至少一部分上以多相基质涂层从所述基底延伸出来。 多相基质涂层包含活性物质并具有第一固相和液相。 第一固相包含水溶性聚合物。 另外，一种在微针阵列上提供含活性物质的基质涂层的方法，其中将水溶性聚合物施加到阵列的微针表面以形成水溶性聚合物的干燥涂层。 制备包含活性物质，能够与水溶性聚合物相分离的液体和载体流体的涂布溶液，并将其涂覆到水溶性聚合物的干燥涂层上。 载体流体的至少一部分从阵列中移除。
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10.发明授权Medicinal aerosol compositions with an amide and/or ester containing excipient compound 失效含有酰胺和/或酯的赋形剂化合物的药用气溶胶组合物公开(公告)号：US07186402B2
公开(公告)日：2007-03-06
申请号：US10327198
申请日：2002-12-20
CPC分类号： A61K9/008 , A61K9/145 , A61K47/183 , Y10S514/958
摘要： The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising an acid or amine end-group and at least one and no more than two amide and/or ester functional groups, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient containing an acid or amine end-group and at least one and no more than two amide and/or ester functional groups.
摘要翻译： 本发明包括药物气溶胶组合物，其包含推进剂，包含酸或胺末端基团和至少一个且不多于两个酰胺和/或酯官能团的赋形剂和药物。 本发明还包括颗粒药物组合物，其包含具有小于约10微米的平均质量空气动力学直径的颗粒，其掺入含有酸或胺端基和至少一个且不超过两个酰胺和/或酯官能团的赋形剂。
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