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    Microneedle Arrays and Methods of Preparing Same
    2.
    发明申请
    Microneedle Arrays and Methods of Preparing Same 审中-公开
    微针阵列及其制备方法

    公开(公告)号：US20080262416A1

    公开(公告)日：2008-10-23

    申请号：US12089551

    申请日：2006-11-17

    申请人： Daniel C. Duan ,  Peter R. Johnson

    发明人： Daniel C. Duan ,  Peter R. Johnson

    IPC分类号： A61M31/00 ,  A61M37/00 ,  B05D5/00

    CPC分类号： B81C1/0038 ,  A61K9/0021 ,  A61K47/26 ,  A61K47/32 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2037/0061 ,  B81B2201/055

    摘要： A microneedle array having a substrate and a plurality of microneedles extending out from the substrate with a multi-phase matrix coating on at least a portion of the microneedle surface of the microneedle array. The multi-phase matrix coating comprises an active substance and has a first solid phase and a liquid phase. The first solid phase comprises a water-soluble polymer. Also, a method of providing an active substance- containing matrix coating on a microneedle array in which a water-soluble polymer is applied to the microneedle surface of the array to form a dried coating of water-soluble polymer. A coating solution comprising an active substance, a liquid capable of phase separating from the water-soluble polymer, and a carrier fluid is prepared and applied to the dried coating of water-soluble polymer. At least a portion of the carrier fluid is removed from the array.

    摘要翻译： 一种微针阵列，其具有基底和多个微针，所述微针在所述微针阵列的所述微针表面的至少一部分上以多相基质涂层从所述基底延伸出来。 多相基质涂层包含活性物质并具有第一固相和液相。 第一固相包含水溶性聚合物。 另外，一种在微针阵列上提供含活性物质的基质涂层的方法，其中将水溶性聚合物施加到阵列的微针表面以形成水溶性聚合物的干燥涂层。 制备包含活性物质，能够与水溶性聚合物相分离的液体和载体流体的涂布溶液，并将其涂覆到水溶性聚合物的干燥涂层上。 载体流体的至少一部分从阵列中移除。

    Low-Profile Microneedle Array Applicator
    6.
    发明申请
    Low-Profile Microneedle Array Applicator 有权
    薄型微针阵列涂布机

    公开(公告)号：US20080114298A1

    公开(公告)日：2008-05-15

    申请号：US11718465

    申请日：2005-11-18

    申请人： Adam S. Cantor ,  Franklyn L. Frederickson ,  Peter R. Johnson ,  Ted K. Ringsred

    发明人： Adam S. Cantor ,  Franklyn L. Frederickson ,  Peter R. Johnson ,  Ted K. Ringsred

    IPC分类号： A61M5/158

    CPC分类号： A61M37/0015 ,  A61M2037/0023

    摘要： An applicator (100) used to apply microneedle arrays (10) to a mammal. In particular, an application device for applying a microneedle device (120) to a skin surface comprising a flexible sheet (110) having a raised central area (115) attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

    摘要翻译： 用于将微针阵列（10）施用于哺乳动物的施加器（100）。 特别地，一种用于将微针装置（120）施加到皮肤表面的施加装置，包括具有附接到微针装置的凸起中心区域（115）的柔性片（110）和位于柔性片 其中所述柔性片被构造成使得其将在与所述片材的主平面正交的方向上进行逐步运动。

    Timepiece having disks of graduated design density
    7.
    发明授权
    Timepiece having disks of graduated design density 失效
    钟表具有刻度设计密度的磁盘

    公开(公告)号：US5943300A

    公开(公告)日：1999-08-24

    申请号：US984218

    申请日：1997-12-03

    申请人： Peter R. Johnson

    发明人： Peter R. Johnson

    IPC分类号： G04B45/00 ,  G04B19/04 ,  G04B19/20 ,  G04B19/06

    CPC分类号： G04B19/046

    摘要： A timepiece that uses disks having sharp zones of contrast of visual design density to indicate time intervals when the sharp zone of contrast is aligned with time interval indicator markings or traditional time indicator positions on a non-rotatable frame. The disks of the chronograph are continuously graduated in visual design density from an area of greatest density to an area of least density to form a sharp zone or line of contrast. The disks are located so that when the sharp zone or line of contrast is aligned with the time indicator markings or positions on the frame, thus displaying the time in an accurate fashion that is easily and quickly discernable even for individuals that are poor sighted. In addition, the timepiece presents such a strikingly novel design that it makes an aesthetic statement that is desirable for use by individuals with no sight problems.

    摘要翻译： 使用具有尖锐视觉设计密度区域的磁盘的时钟表示当对比度的尖锐区域与不可旋转的框架上的时间间隔指示符标记或传统的时间指示器位置对准时的时间间隔。 计时码表的磁盘以视觉设计密度从最大密度的区域连续刻度到最小密度的区域，形成锋利的区域或对比线。 这些盘被定位成使得当锋利区域或对比线与时间指示器标记​​或框架上的位置对准时，从而以准确的方式显示时间，即使对于看不见的人也容易且快速地辨别。 此外，这款腕表呈现出这样一种惊人的新颖设计，使得美学上的声明对于没有视力问题的个人而言是理想的。

    MEDICINAL FORMULATION CONTAINER WITH A TREATED METAL SURFACE
    9.
    发明申请
    MEDICINAL FORMULATION CONTAINER WITH A TREATED METAL SURFACE 审中-公开
    具有处理金属表面的药物制剂容器

    公开(公告)号：US20090050143A1

    公开(公告)日：2009-02-26

    申请号：US12293216

    申请日：2007-03-23

    申请人： Larry D. Boardman ,  Peter R. Johnson ,  Gary A. Korba ,  Mark E. Mueller ,  Mark J. Pellerite ,  Ravi Ravichandran

    发明人： Larry D. Boardman ,  Peter R. Johnson ,  Gary A. Korba ,  Mark E. Mueller ,  Mark J. Pellerite ,  Ravi Ravichandran

    IPC分类号： A61M15/00 ,  C23C22/05

    CPC分类号： A61M15/009 ,  A61M2205/0222 ,  B65D83/54 ,  B82Y30/00 ,  C23C22/03 ,  C23C30/00

    摘要： A container, such as a metered dose inhaler, suitable for use with a propellant-based medicinal formulation, the container comprising one or more treated metal surfaces that come into contact with the medicinal formulation, wherein the one or more treated metal surfaces are characterized by an organic surface treatment compound covalently bonded to the metal surface through a reactive head group selected from either phosphonic acid or carboxylic acid and wherein the organic surface treatment compound is further characterized by an exposed, substantially non-reactive tail group disposed away from the metal surface. Also, metered dose inhaler canisters and valves with treated surfaces.

    摘要翻译： 一种容器，例如计量吸入器，适用于基于推进剂的药物制剂，所述容器包括与药物制剂接触的一种或多种经处理的金属表面，其中所述一种或多种经处理的金属表面的特征在于 通过选自膦酸或羧酸的反应性头基团共价结合到金属表面的有机表面处理化合物，其中有机表面处理化合物的进一步特征在于远离金属表面放置的暴露的，基本上不反应的尾基 。 此外，计量吸入器罐和具有处理表面的阀。

    Coatable Compositions, Coatings Derived Therefrom and Microarrays Having Such Coatings
    10.
    发明申请
    Coatable Compositions, Coatings Derived Therefrom and Microarrays Having Such Coatings 有权
    可涂覆组合物，衍生自其的涂层和具有这种涂层的微阵列

    公开(公告)号：US20080294116A1

    公开(公告)日：2008-11-27

    申请号：US12092733

    申请日：2006-11-17

    申请人： James T. Wolter ,  John K. Simons ,  Peter R. Johnson

    发明人： James T. Wolter ,  John K. Simons ,  Peter R. Johnson

    IPC分类号： A61M5/32 ,  A61K39/00

    CPC分类号： A61K9/0021 ,  A61K47/12 ,  A61K47/26 ,  A61K47/32 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.

    摘要翻译： 描述了可涂覆组合物和衍生自可涂覆组合物的涂层，以及包含这种涂层的微阵列。 一方面，本发明提供了一种微阵列，包括：多个从支撑基板延伸的微针; 沉积在所述多个微针中的至少一个上的涂层，所述涂层包含活性剂和生物盐。 另一方面，本发明提供一种可涂覆组合物，其包含：活性剂; 生物盐; 和溶剂。 另一方面，本发明提供涂覆在微针上的干燥涂层，所述涂层包含：活性剂; 和生物盐。