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    Integrated monolithic microfabricated electrospray and liquid chromatography system and method
    2.
    发明授权
    Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权

    公开(公告)号：US06579452B1

    公开(公告)日：2003-06-17

    申请号：US09707653

    申请日：2000-11-07

    申请人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    发明人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    IPC分类号： B01D1508

    CPC分类号： G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

    摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

    Integrated monolithic microfabricated electrospray and liquid chromatography system and method
    3.
    发明授权
    Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权

    公开(公告)号：US06569324B1

    公开(公告)日：2003-05-27

    申请号：US09703005

    申请日：2000-10-31

    申请人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    发明人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    IPC分类号： H01J4910

    CPC分类号： G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

    摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

    Integrated monolithic microfabricated electrospray and liquid chromatography system and method
    4.
    发明授权
    Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权

    公开(公告)号：US06563111B1

    公开(公告)日：2003-05-13

    申请号：US09703246

    申请日：2000-10-31

    申请人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    发明人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    IPC分类号： H01J4904

    CPC分类号： G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

    摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

    Integrated monolithic microfabricated electrospray and liquid chromatography system and method
    6.
    发明授权
    Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
    集成的单片微电解电喷雾和液相色谱系统及方法

    公开(公告)号：US06800202B2

    公开(公告)日：2004-10-05

    申请号：US09745629

    申请日：2000-12-21

    申请人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    发明人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    IPC分类号： B01D1508

    CPC分类号： G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

    摘要： An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

    摘要翻译： 公开了电喷雾装置，液相色谱装置和电喷雾液相色谱系统。 电喷雾装置包括：基材，其限定在喷射表面上的入口孔与喷射表面上的出口孔之间的通道;由从出射孔周围的喷射表面凹陷的部分限定的喷嘴;以及用于施加电 对基板进行优化和产生电喷雾的潜力; 和可选的附加电极以进一步改变电喷雾。 所述液相色谱装置包括分隔衬底，所述分离衬底限定入口孔和贮存器之间的引入通道以及所述储存器和出口孔之间的分离通道，所述分离通道具有垂直于所述流体流动的分离柱; 覆盖基板，其结合到分离基板以封闭储存器和与盖基板相邻的分离通道; 和可选地用于向流体施加电势的电极。 液相色谱装置的出口可以与电喷雾装置的入口孔均匀地接合，以形成一个集成的单一系统。 多个系统的阵列可以制造在单个单片芯片中，用于快速顺序流体处理和产生用于后续分析的电喷雾，例如通过将电喷雾装置的出口孔定位在质谱仪的采样孔附近。

    Integrated monolithic microfabricated electrospray and liquid chromatography system and method
    7.
    发明授权
    Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权
    集成的单片微电解电喷雾和液相色谱系统及方法

    公开(公告)号：US06790354B1

    公开(公告)日：2004-09-14

    申请号：US09698329

    申请日：2000-10-27

    申请人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    发明人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    IPC分类号： B01D1508

    CPC分类号： G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

    摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

    摘要翻译： 公开了电喷雾装置，液相色谱装置和电喷雾 - 液相色谱系统。 电喷雾装置包括：基材，其限定在喷射表面上的入口孔与喷射表面上的出口孔之间的通道;由从出射孔周围的喷射表面凹陷的部分限定的喷嘴;以及用于施加电 对基板进行优化和产生电喷雾的潜力; 和可选的附加电极以进一步改变电喷雾。 所述液相色谱装置包括分隔衬底，所述分离衬底限定入口孔和贮存器之间的引入通道以及所述储存器和出口孔之间的分离通道，所述分离通道具有垂直于所述流体流动的分离柱; 覆盖基板，其结合到分离基板以封闭储存器和与盖基板相邻的分离通道; 和可选地用于向流体施加电势的电极。 液相色谱装置的出口可以与电喷雾装置的入口孔均匀地接合，以形成一个集成的单一系统。 多个系统的阵列可以制造在单个单片芯片中，用于快速顺序流体处理和产生用于后续分析的电喷雾，例如通过将电喷雾装置的出口孔定位在质谱仪的采样孔附近。

    Integrated monolithic microfabricated electrospray and liquid chromatography system and method
    8.
    发明授权
    Integrated monolithic microfabricated electrospray and liquid chromatography system and method 有权

    公开(公告)号：US06780313B1

    公开(公告)日：2004-08-24

    申请号：US09702955

    申请日：2000-10-31

    申请人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    发明人： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

    IPC分类号： B01D1508

    CPC分类号： G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

    摘要： An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.