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公开(公告)号：US08530039B2
公开(公告)日：2013-09-10
申请号：US12534329
申请日：2009-08-03
申请人： James H. Adair , Mary Frecker , Christopher Muhlstein , Eric Mockensturm , Harriet Black Nembhard , Randy S. Haluck , Abraham Mathew , Nicholas Antolino , Gregory R Hayes , Milton Aguirre , Rebecca Kirkpatrick , Chumpol Yuangyai
发明人： James H. Adair , Mary Frecker , Christopher Muhlstein , Eric Mockensturm , Harriet Black Nembhard , Randy S. Haluck , Abraham Mathew , Nicholas Antolino , Gregory R Hayes , Milton Aguirre , Rebecca Kirkpatrick , Chumpol Yuangyai
CPC分类号： A61B17/30 , A61B2017/00345 , A61B2017/00526 , A61B2017/00831 , B81B2203/019 , B81C99/002 , B81C99/0085
摘要： A polycrystalline mesoscale component, formed through a process including filing a mold cavity formed in a photoresist with a mold fill, is provided with an overall length L divided into multiple segments with a second segment extending from a first segment at a nonlinear angle. The first segment has a first segment height H1 and a first segment thickness T1, while the second segment has a second segment height H2 and a second segment thickness T2, with the lesser of H1 and H2 defining a minimum segment height Hmin and the lesser of T1 and T2 defining a minimum segment thickness Tmin. The resultant component has a ratio of L:Hmin:Tmin of 20-80:1:0.5-10 where Hmin is between 5 and 500 microns. In specific instances, the nonlinear angle is acute, the multiple segments are rectilinear in cross section, and a segment thickness has an edge resolution of between 0.1 and 2 microns.
摘要翻译： 通过包括用模具填充物形成在光致抗蚀剂中的模具腔的方法形成的多晶中尺度部件设置有分为多个段的总长度L，第二段以非线性角度从第一段延伸。 第一段具有第一段高度H1和第一段厚度T1，而第二段具有第二段高度H2和第二段厚度T2，其中较小的H1和H2限定最小段高度Hmin，并且较小的 T1和T2限定最小段厚度Tmin。 所得组分的比例为20：80：1：0.5-10的L：Hmin：Tmin，其中Hmin为5至500微米。 在具体情况下，非线性角度是锐角的，多个截面的横截面是直线的，而段的厚度分辨率在0.1到2微米之间。
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公开(公告)号：US20100075170A1
公开(公告)日：2010-03-25
申请号：US12534329
申请日：2009-08-03
申请人： James H. Adair , Mary Frecker , Christopher Muhlstein , Eric Mockensturm , Randy S. Haluck , Abraham Mathew , Milton Aguirre , Rebecca Kirkpatrick , Chumpol Yuangyai
发明人： James H. Adair , Mary Frecker , Christopher Muhlstein , Eric Mockensturm , Randy S. Haluck , Abraham Mathew , Milton Aguirre , Rebecca Kirkpatrick , Chumpol Yuangyai
CPC分类号： A61B17/30 , A61B2017/00345 , A61B2017/00526 , A61B2017/00831 , B81B2203/019 , B81C99/002 , B81C99/0085
摘要： A polycrystalline mesoscale component is provided that has an overall length L divided into multiple segments with a second segment extending from a first segment at a nonlinear angle. The first segment has a first segment height H1 and a first segment thickness T1, while the second segment has a second segment height H2 and a second segment thickness T1, with the lesser of H1 and H2 defining a minimum segment height Hmin and the lesser of T1 and T2 defining a minimum segment thickness Tmin. The resultant component has a ratio of L:Hmin:Tmin of 20-80:1:0.5-10 where Hmin is between 5 and 500 microns. In specific instances, the nonlinear angle is acute, the multiple segments are rectilinear in cross section, and a segment thickness has an edge resolution of between 0.1 and 2 microns.A process for forming a polycrystalline mesoscale component is provided that includes filling a mold cavity formed in a photoresist with a mold fill. The mold fill includes a slurry of particles of ceramic, metal, or a combination thereof in a polymerizable monomer in an amount to form a polymer that imparts strength to the mold fill. Thereafter the photoresist is removed and the gel cast mold fill is heated to remove the polymer and form the polycrystalline sintered mesoscale component. In a particular embodiment, the mold fill after removal of the photoresist is heated in contact with a second mold fill to form a composite component with a sintered interface between the mold fill and the second mold fill.
摘要翻译： 提供了多晶中尺度部件，其具有被分成多个段的总长度L，第二段以非线性角度从第一段延伸。 第一段具有第一段高度H1和第一段厚度T1，而第二段具有第二段高度H2和第二段厚度T1，其中较小的H1和H2限定最小段高度Hmin，并且较小的 T1和T2限定最小段厚度Tmin。 所得组分的比例为20：80：1：0.5-10的L：Hmin：Tmin，其中Hmin为5至500微米。 在具体情况下，非线性角度是锐角的，多个截面的横截面是直线的，而段的厚度分辨率在0.1到2微米之间。 提供一种用于形成多晶中尺度部件的方法，其包括用模具填充物填充形成在光致抗蚀剂中的模腔。 模具填充物包括陶瓷，金属或其组合的颗粒在可聚合单体中的浆料，其量形成赋予模具填充物强度的聚合物。 此后，除去光致抗蚀剂，并加热凝胶铸模填料以除去聚合物并形成多晶烧结中尺度组分。 在特定实施例中，去除光致抗蚀剂之后的模具填充物与第二模具填充物接触地加热，以形成具有在模具填充物和第二模具填充物之间的烧结界面的复合部件。
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3.发明授权In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles 有权通过封装在磷酸钙纳米粒子中的近红外线的体内光动力治疗癌症公开(公告)号：US08771741B2
公开(公告)日：2014-07-08
申请号：US12657556
申请日：2010-01-22
申请人： James H. Adair , Mark Kester , Erhan I. Altinoglu , Brian M. Barth , Timothy J. Russin , James M. D. Kaiser , Thomas T. Morgan , Karen L. Eklund
发明人： James H. Adair , Mark Kester , Peter C. Eklund , Erhan I. Altinoglu , Brian M. Barth , Timothy J. Russin , James M. D. Kaiser , Thomas T. Morgan
IPC分类号： A61K9/14
CPC分类号： A61K41/0057 , A61K9/51 , A61K47/6921 , A61K47/6923
摘要： Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.
摘要翻译： 描述了纳米包封的光敏剂及其在治疗肿瘤和/或成像中的用途。 优选地，将光敏剂包封在磷酸钙纳米颗粒（CPNP）中。 将PS封装在CPNP中增加PS的半衰期，增加PS进入靶细胞组织的吸收，增加PS的光稳定性，增加PS的光效，增加PS的体内保留或组合 最终使其成为用于光动力疗法，成像靶组织，血管或肿瘤，和/或检测或定位肿瘤的高效药物。
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公开(公告)号：US20110046241A1
公开(公告)日：2011-02-24
申请号：US12546369
申请日：2009-08-24
CPC分类号： D21H19/38 , C02F1/50 , C02F2303/08
摘要： The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers. As such, the particle can be used in a variety of applications including any of a variety of high temperature, at acidic, neutral, or basic pH, or pressure environments. The carrier particles have applications as diverse as papermaking, water treatment, chemical tracing, personal care, microbiological control, oil recovery, delivery of polymers, for example.
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5.发明申请In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles 有权通过封装在磷酸钙纳米粒子中的近红外线的体内光动力治疗癌症公开(公告)号：US20100247436A1
公开(公告)日：2010-09-30
申请号：US12657556
申请日：2010-01-22
申请人： James H. Adair , Mark Kester , Peter C. Eklund , Karen L. Eklund , Erhan Altinoglu , Brian M. Barth , Timothy J. Russin , James M.D. Kaiser , Thomas T. Morgan
发明人： James H. Adair , Mark Kester , Peter C. Eklund , Karen L. Eklund , Erhan Altinoglu , Brian M. Barth , Timothy J. Russin , James M.D. Kaiser , Thomas T. Morgan
CPC分类号： A61K41/0057 , A61K9/51 , A61K47/6921 , A61K47/6923
摘要： Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.
摘要翻译： 描述了纳米包封的光敏剂及其在治疗肿瘤和/或成像中的用途。 优选地，将光敏剂包封在磷酸钙纳米颗粒（CPNP）中。 将PS封装在CPNP中增加PS的半衰期，增加PS进入靶细胞组织的吸收，增加PS的光稳定性，增加PS的光效，增加PS的体内保留或组合 最终使其成为用于光动力疗法，成像靶组织，血管或肿瘤，和/或检测或定位肿瘤的高效药物。
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6.发明申请Bioconjugation of Calcium Phosphosilicate Nanoparticles For Selective Targeting of Cells In Vivo 有权磷酸钙纳米粒子用于体内细胞选择性靶向的生物缀合公开(公告)号：US20110129413A1
公开(公告)日：2011-06-02
申请号：US12941719
申请日：2010-11-08
申请人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
发明人： Thomas T. Morgan , Brian M. Barth , James H. Adair , Rahul Sharma , Mark Kester , Sriram S. Shanmugavelandy , Jill P. Smith , Erhan I. Altinoglu , Gail L. Matters , James M. Kaiser , Christopher McGovern
IPC分类号： A61K51/12 , C07K14/77 , C07K16/00 , C07K2/00 , C07K7/06 , A61K49/00 , A61K47/42 , A61K47/22 , A61K49/18 , A61K9/14 , B82Y5/00 , B82Y40/00
CPC分类号： A61K49/0093 , A61K41/0057 , A61K47/48861 , A61K47/6923 , A61K49/0034 , A61K49/0043
摘要： Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.
摘要翻译： 非聚集的可再吸收的磷酸钙纳米粒子（CPNP）被生物缀合成靶向特定细胞特异性的分子。 CPNPs在正常生理pH下是稳定的颗粒。 化疗和成像剂可以与CPNP整体形成，使得它们在CPNP内被分隔。 以这种方式，保护试剂免于在正常生理pH下与环境的相互作用。 然而，一旦CPNP被摄取，在细胞内的pH值下，CPNP溶解释放药剂。 因此，化学治疗或显像剂被递送到特定的细胞并允许这些细胞的治疗和/或成像。 使用生物共轭CPNP都限制了全身暴露于药剂的量，并将更高浓度的药剂递送至细胞。 生物缀合CPNP的方法和原理通过乳腺癌，胰腺癌和白血病靶向分子的生物缀合的实例来教导。
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公开(公告)号：US20110046240A1
公开(公告)日：2011-02-24
申请号：US12546336
申请日：2009-08-24
CPC分类号： A01N25/08 , C02F1/50 , C02F2303/08
摘要： The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers. As such, the particle can be used in a variety of applications including any of a variety of high temperature, at acidic, neutral, or basic pH, or pressure environments. The carrier particles have applications as diverse as papermaking, water treatment, chemical tracing, personal care, microbiological control, oil recovery, delivery of polymers, for example.
摘要翻译： 本发明涉及一种钙基载体颗粒的形成方法，该钙基载体颗粒由钙基材料，活性物质，表面改性活性物质，稳定剂和相关组合物组成。 钙基颗粒由通式Cax（PO4）y（OH）zR表示，也可以包括二氧化硅或二氧化硅氧化物取代基。 R是活性物质或活性物质，例如有机或无机分子，其包括标记物，胺，硫醇，环氧化物，有机硅氧烷，有机硅烷，硫酸盐和水溶性试剂，并且根据需要可以是表面改性S，其可以是有机的或有机的 无机的。 可能需要稳定剂以保持颗粒在水性介质中的分散。 表面改性材料和稳定剂的实例是铝和硼的无机盐或有机材料如有机硅烷或低分子量聚合物。 因此，颗粒可以用于各种应用，包括各种高温，酸性，中性或碱性pH或压力环境中的任何一种。 载体颗粒具有例如造纸，水处理，化学追踪，个人护理，微生物控制，油回收，聚合物递送等应用。
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公开(公告)号：US20110046239A1
公开(公告)日：2011-02-24
申请号：US12546319
申请日：2009-08-24
申请人： Bruce A. Keiser , Timothy S. Keizer , Brett M. Showalter , Tiffany Bohnsack , James H. Adair , Mylisa Parette , Amy Knupp , Andrei S. Zelenev , Jason R. Burney
发明人： Bruce A. Keiser , Timothy S. Keizer , Brett M. Showalter , Tiffany Bohnsack , James H. Adair , Mylisa Parette , Amy Knupp , Andrei S. Zelenev , Jason R. Burney
CPC分类号： A01N25/08 , C02F1/50 , C02F2303/08
摘要： The present invention relates to a method for forming a calcium-based carrier particle consisting of the calcium-based material, an active, with or without a surface modification, a stabilizing agent, and the related composition. The calcium-based particle is illustrated by the general formula Cax(PO4)y(OH)zR and may also include a silica or silica oxide substituent. R is an active or actives such as an organic or inorganic molecule that includes markers, amines, thiols, epoxies, organosilicones, organosilanes, sulfates, and water soluble agents and, as needed, a surface modification, S, which may be either organic or inorganic. A stabilizing agent may be necessary to maintain dispersion of the particles in aqueous media. Examples of a surface modifying material and stabilizing agents are inorganic salts of aluminum and boron or organic materials such as organosilanes or low molecular weight polymers. As such, the particle can be used in a variety of applications including any of a variety of high temperature, at acidic, neutral, or basic pH, or pressure environments. The carrier particles have applications as diverse as papermaking, water treatment, chemical tracing, personal care, microbiological control, oil recovery, delivery of polymers, for example.
摘要翻译： 本发明涉及一种钙基载体颗粒的形成方法，该钙基载体颗粒由钙基材料，活性物质，表面改性活性物质，稳定剂和相关组合物组成。 钙基颗粒由通式Cax（PO4）y（OH）zR表示，也可以包括二氧化硅或二氧化硅氧化物取代基。 R是活性物质或活性物质，例如有机或无机分子，其包括标记物，胺，硫醇，环氧化物，有机硅氧烷，有机硅烷，硫酸盐和水溶性试剂，并且根据需要可以是表面改性S，其可以是有机的或有机的 无机的。 可能需要稳定剂以保持颗粒在水性介质中的分散。 表面改性材料和稳定剂的实例是铝和硼的无机盐或有机材料如有机硅烷或低分子量聚合物。 因此，颗粒可以用于各种应用，包括各种高温，酸性，中性或碱性pH或压力环境中的任何一种。 载体颗粒具有例如造纸，水处理，化学追踪，个人护理，微生物控制，油回收，聚合物递送等应用。
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公开(公告)号：US06514894B1
公开(公告)日：2003-02-04
申请号：US09693407
申请日：2000-10-20
IPC分类号： C04B3546
CPC分类号： C04B35/63488 , C04B35/581 , C04B35/584 , C04B35/632 , C04B35/634 , C04B35/63444
摘要： A uniform suspension of ceramic powder and method for making the same. The suspension is prepared by mixing finely divided ceramic powder in an aqueous carrier fluid, combining with a dispersing agent, and alternatively, an organic binder when forming a slip. The ceramic powder has an average particle size of about 0.5 micron or less and is present in the suspension in a loading of up to 30% by volume of the total solids in suspension. A passivating agent is present in the carrier fluid in an amount of 0.5 to 5% by weight of the ceramic powder present for suspension and slip respectively. After the addition of a dispersant, the suspension has a Bingham yield point of less than 230 dynes/cm2 and an apparent viscosity of less than 3000 cps. A green layer produced from the slip exhibits a pore size of less than 0.5 micron.
摘要翻译： 陶瓷粉末的均匀悬浮液及其制造方法。 通过将细分散的陶瓷粉末混合在水性载体流体中，与分散剂组合，或者在形成滑移时与有机粘合剂混合来制备悬浮液。 陶瓷粉末具有约0.5微米或更小的平均粒度，并且以悬浮液中总固体的至多30体积％的负载量存在于悬浮液中。 载体流体中的钝化剂分别以用于悬浮和滑动的陶瓷粉末的0.5至5重量％的量存在。 添加分散剂后，悬浮液的Bingham屈服点小于230达因/ cm2，表观粘度小于3000cps。 由滑动层产生的绿色层表现出小于0.5微米的孔径。
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公开(公告)号：US4619817A
公开(公告)日：1986-10-28
申请号：US716428
申请日：1985-03-27
IPC分类号： C01G25/02 , C04B35/486
CPC分类号： B82Y30/00 , C01G25/02 , C04B35/486 , C01P2004/03 , C01P2004/50 , C01P2004/61 , C01P2004/64 , C01P2006/60 , C01P2006/80
摘要： The invention is characterized by two main methods of producing stabilized or partially stabilized zirconia powders with controlled particle size by use of complexing agents and hydrothermal treatment. A further embodiment of the invention is characterized by a combination of the first two methods to produce powders containing more than one major particle size. The invention also allows use of low cost readily available starting material, controlled doping level and incorporation of dual constituents such as MgO, CaO; Y.sub.2 O.sub.3, MgO; or Y.sub.2 O.sub.3, CaO in the structure for production of stabilized zirconia. Triply stabilized zirconia containing Y.sub.2 O.sub.3, MgO and CaO may also be produced. A final embodiment of the invention allows the production of dually and triply stabilized zirconia by hydrothermal treatment without the use of complexing agents.
摘要翻译： 本发明的特征在于通过使用络合剂和水热处理制备具有受控粒度的稳定或部分稳定的氧化锆粉末的两种主要方法。 本发明的另一个实施方案的特征在于前两种方法的组合以产生含有多于一种主要粒度的粉末。 本发明还允许使用低成本易得的起始材料，受控的掺杂水平和双组分如MgO，CaO的掺入; Y2O3，MgO; 或Y2O3，CaO在稳定氧化锆生产的结构中。 也可以生产含有Y 2 O 3，MgO和CaO的三稳态氧化锆。 本发明的最终实施方案允许通过水热处理生产双重和三重稳定的氧化锆，而不使用络合剂。
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