公开(公告)号：US06994999B1

公开(公告)日：2006-02-07

申请号：US09743312

申请日：1999-07-07

申请人： James J. Bass ,  Ferenc Jeanplong ,  Ravi Kambadur ,  Mridula Sharma

发明人： James J. Bass ,  Ferenc Jeanplong ,  Ravi Kambadur ,  Mridula Sharma

IPC分类号： C12N15/64 ,  C12N1/00 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC分类号： C12N15/85 ,  C12N2830/00 ,  C12N2830/85

摘要： The present invention relates to a novel promoter sequence which encodes an isolated DNA molecule comprising the polynucleotide sequence of SEQ ID NO: 1 and which encodes the promoter region of the myostatin gene, or a fragment thereof, or variant thereof which has been modified by the insertion, substitution or deletion of one or more nucleotides, said fragment and variant of said polynucleotide sequence having substantially equivalent function thereto.

摘要翻译： 本发明涉及编码分离的DNA分子的新型启动子序列，该分离的DNA分子包含SEQ ID NO：1的多核苷酸序列，其编码肌生长抑制素基因或其片段或其变体的启动子区，其已被 插入，取代或缺失一个或多个核苷酸，所述多核苷酸序列的所述片段和变体具有与其基本相同的功能。

公开(公告)号：US08455448B2

公开(公告)日：2013-06-04

申请号：US13085263

申请日：2011-04-12

申请人： Ferenc Jeanplong ,  Christopher David McMahon

发明人： Ferenc Jeanplong ,  Christopher David McMahon

IPC分类号： A61K38/10 ,  A61K38/16 ,  A61K35/34 ,  A61P21/00

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07H21/04

摘要： The present invention provides splice variants of myostatin that promote muscle growth, and include polynucleotides and polypeptide sequences, constructs comprising the sequences and compositions for regulating muscle growth and treating diseases associated with muscle tissue. The splice variants include the consensus sequence X1 I F L E X2 X3 X4 Q X5 C S I L X6 X7 X8 X9 X10 wherein X1 is I or L, X2 is V or L, X3 is Y, C, G or S, X4 is I or F, X5 is F or L, X6 is G or E, X7 is E or V, X8 is A or T, X9 is A or V and X10 is absent, F or L. The present invention also provides for the use of the present sequences in identifying animals with altered muscle mass, and for use in selective breeding programs to produce animals with altered muscle mass.

摘要翻译： 本发明提供了促进肌肉生长的肌生成抑制素的剪接变体，并且包括多核苷酸和多肽序列，包含用于调节肌肉生长和治疗与肌肉组织相关的疾病的序列和组合物的构建体。 拼接变体包括共有序列X1 IFLE X2 X3 X4 Q X5 CSIL X6 X7 X8 X9 X10其中X1为I或L，X2为V或L，X3为Y，C，G或S，X4为I或F，X5 是F或L，X 6是G或E，X 7是E或V，X 8是A或T，X 9是A或V，X 10不存在，F或L。本发明还提供了本 识别具有改变的肌肉质量的动物，并用于选择性育种程序以产生具有改变的肌肉质量的动物。

公开(公告)号：US20110258712A1

公开(公告)日：2011-10-20

申请号：US13085263

申请日：2011-04-12

申请人： Ferenc Jeanplong ,  Christopher David McMahon

发明人： Ferenc Jeanplong ,  Christopher David McMahon

IPC分类号： A01K67/02 ,  C07K14/475 ,  A61P9/00 ,  A61K38/18 ,  A61P21/00 ,  C07K7/08 ,  G01N33/566

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07H21/04

摘要： The present invention provides splice variants of myostatin that promote muscle growth, and include polynucleotides and polypeptide sequences, constructs comprising the sequences and compositions for regulating muscle growth and treating diseases associated with muscle tissue. The splice variants include the consensus sequence X1 I F L E X2 X3 X4 Q X5 C S I L X6 X7 X8 X9 X10 wherein X1 is I or L, X2 is V or L, X3 is Y, C, G or S, X4 is I or F, X5 is F or L, X6 is G or E, X7 is E or V, X8 is A or T, X9 is A or V and X10 is absent, F or L. The present invention also provides for the use of the present sequences in identifying animals with altered muscle mass, and for use in selective breeding programs to produce animals with altered muscle mass.

摘要翻译： 本发明提供了促进肌肉生长的肌生成抑制素的剪接变体，并且包括多核苷酸和多肽序列，包含用于调节肌肉生长和治疗与肌肉组织相关的疾病的序列和组合物的构建体。 拼接变体包括共有序列X1 IFLE X2 X3 X4 Q X5 CSIL X6 X7 X8 X9 X10其中X1为I或L，X2为V或L，X3为Y，C，G或S，X4为I或F，X5 是F或L，X 6是G或E，X 7是E或V，X 8是A或T，X 9是A或V，X 10不存在，F或L。本发明还提供了本 识别具有改变的肌肉质量的动物，并用于选择性育种程序以产生具有改变的肌肉质量的动物。

公开(公告)号：US20080118487A1

公开(公告)日：2008-05-22

申请号：US11576449

申请日：2005-09-30

申请人： Ferenc Jeanplong ,  Christopher David McMahon

发明人： Ferenc Jeanplong ,  Christopher David McMahon

IPC分类号： A61K39/00 ,  C07K16/00 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12Q1/00 ,  A01K29/00 ,  G01N33/53 ,  C12Q1/68 ,  A01K67/00 ,  A61K38/00 ,  A61K31/70

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07H21/04

摘要： The present invention provides splice variants of myostatin that promote muscle growth, and include polynucleotides and polypeptide sequences, constructs comprising the sequences and compositions for regulating muscle growth and treating diseases associated with muscle tissue. The splice variants include the consensus sequence X1 I F L E X2 X3 X4 Q X5 C S I L X6 X7 X8 X9 X10 wherein X1 is I or L, X2 is V or L, X3 is Y, C, G or S, X4 is I or F, X5 is F or L, X6 is G or E, X7 is E or V, X8 is A or T, X9 is A or V and X10 is absent, F or L. The present invention also provides for the use of the present sequences in identifying animals with altered muscle mass, and for use in selective breeding programs to produce animals with altered muscle mass.

摘要翻译： 本发明提供了促进肌肉生长的肌生成抑制素的剪接变体，并且包括多核苷酸和多肽序列，包含用于调节肌肉生长和治疗与肌肉组织相关的疾病的序列和组合物的构建体。 拼接变体包括共有序列X 1，X 3，X 3，X 4，X 3，X 3， 其中X X X 其中X < SUB> 1是I或L，X 2是V或L，X 3是Y，C，G或S，X 4， / SUB>是I或F，X 5是F或L，X 6是G或E，X 7是E或V， X 8是A或T，X 9是A或V，X 10不存在，F或L.本发明还提供了 使用本发明的序列来鉴定具有改变的肌肉质量的动物，并且用于选择性育种程序以产生具有改变的肌肉质量的动物。