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    METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS
    8.
    发明申请
    METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS 审中-公开
    用于检测和破坏癌细胞的方法和方法

    公开(公告)号：US20150376209A1

    公开(公告)日：2015-12-31

    申请号：US12778569

    申请日：2010-05-12

    申请人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    发明人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    IPC分类号： C07F1/00 ,  A61N1/40 ,  C09B23/01 ,  A61K49/00 ,  A61K41/00

    CPC分类号： C07F1/00 ,  A61K41/0052 ,  A61K41/0057 ,  A61K49/0032 ,  A61K49/0093 ,  A61N1/406 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/086

    摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

    摘要翻译： 本发明涉及新的碳菁染料组合物，包含这种组合物的药物组合物，通过近红外荧光成像检测初始癌细胞的方法和通过施用这种药物组合物鉴定的癌细胞的选择性破坏。 一种检测和破坏癌细胞的方法包括将金染料引入怀疑具有癌细胞的生物体中。 金染料是共价连接到金纳米颗粒上的碳菁染料。 近红外光照射在怀疑患有癌细胞的区域。 检测到来自金色染料的荧光。 射频能量束被引导到该区域以诱导癌细胞中的高热。 碳菁染料具有MHI-148和结构6和22的最基本结构，在赋予癌细胞活性的环己烯环上具有Aun- [CH 2（CH 2）9 CH 2 - （OCH 2 CH 2）4 O] COCH 2 CH 2 - 苯基-O基团 绑定和销毁过程。

    Method and dyes for detecting and destroying cancer cells
    9.
    发明授权
    Method and dyes for detecting and destroying cancer cells 有权

    公开(公告)号：US10030036B2

    公开(公告)日：2018-07-24

    申请号：US12778569

    申请日：2010-05-12

    申请人： James J. Krutak ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    发明人： James J. Krutak ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    IPC分类号： A61N1/40 ,  C07F1/00 ,  A61K49/00 ,  A61K41/00 ,  C09B23/01 ,  C09B23/08

    摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.