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1.发明申请Modulation of Stat 6 Expression for the Treatment of Airway Hyperresponsiveness 审中-公开调节Stat 6表达用于治疗气道高反应性公开(公告)号：US20100202977A9
公开(公告)日：2010-08-12
申请号：US11914131
申请日：2006-05-12
IPC分类号： A61K9/12 , C07H21/04 , A61P11/00 , A61K31/711 , A61K48/00
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节STAT6在细胞，组织或动物中的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗与STAT6表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：US20080311052A1
公开(公告)日：2008-12-18
申请号：US11914131
申请日：2006-05-12
IPC分类号： A61K9/12 , C07H21/04 , A61P11/00 , A61K31/711
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节STAT6在细胞，组织或动物中的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗与STAT6表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：US07176303B2
公开(公告)日：2007-02-13
申请号：US10704263
申请日：2003-11-06
申请人： Susan M. Freier , James Karras
发明人： Susan M. Freier , James Karras
IPC分类号： C07H21/04
CPC分类号： C07K14/4702 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/321 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节STAT5的表达。 组合物包含针对编码STAT5的核酸的寡核苷酸。 提供了使用这些化合物调节STAT5表达和用于诊断和治疗与STAT5表达相关的疾病和病症的方法。
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公开(公告)号：US20070293663A1
公开(公告)日：2007-12-20
申请号：US11556565
申请日：2006-11-03
申请人： Susan Freier , James Karras
发明人： Susan Freier , James Karras
IPC分类号： C07H21/00
CPC分类号： C07K14/4702 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/321 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节STAT5的表达。 组合物包含针对编码STAT5的核酸的寡核苷酸。 提供了使用这些化合物调节STAT5表达和用于诊断和治疗与STAT5表达相关的疾病和病症的方法。
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公开(公告)号：US20050238606A1
公开(公告)日：2005-10-27
申请号：US11112451
申请日：2005-04-21
申请人： Sujatha Dokka , Scott Cooper , Susan Kelly , Greg Hardee , James Karras
发明人： Sujatha Dokka , Scott Cooper , Susan Kelly , Greg Hardee , James Karras
CPC分类号： A61K8/606 , A61K9/0014 , A61K9/127 , A61K47/14 , A61K48/0075 , A61Q7/02 , C12N15/87 , Y02A50/401
摘要： The present invention relates to compositions and methods which enhance the delivery of nucleic acids and other nucleosidic moieties via topical routes of administration. The invention relates to the use of an aqueous solution to preferentially deliver nucleic acids preferentially to hair follicles. The invention relates to a method of inhibiting hair growth comprising administration of a nucleic acid preferentially to a hair follicle.
摘要翻译： 本发明涉及通过局部施用途径增强核酸和其它核苷部分的递送的组合物和方法。 本发明涉及水溶液优先将核酸优先递送至毛囊的用途。 本发明涉及一种抑制毛发生长的方法，包括将核酸优先施用于毛囊。
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6.发明申请OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN 失效寡核苷酸组合物和调节B7蛋白表达的方法公开(公告)号：US20080027019A1
公开(公告)日：2008-01-31
申请号：US11748422
申请日：2007-05-14
申请人： Timothy Vickers , C. Bennett , Susan Freier , James Karras
发明人： Timothy Vickers , C. Bennett , Susan Freier , James Karras
IPC分类号： A61K31/7088 , A61K31/7115 , A61K31/7125 , A61P29/00
CPC分类号： A61K31/7088 , A61K31/7115 , A61K31/7125 , Y02P20/582
摘要： Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.
摘要翻译： 用与编码B7蛋白的核酸特异性杂交的寡核苷酸治疗哮喘的组合物和方法。
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公开(公告)号：US07033830B2
公开(公告)日：2006-04-25
申请号：US10673063
申请日：2003-09-26
申请人： James Karras , Kenneth Dobie
发明人： James Karras , Kenneth Dobie
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for modulation of MyD88 expression and for treatment of diseases associated with expression of MyD88 are provided.
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8.发明申请Antisense modulation of sterol regulatory element-binding protein-1 expression 审中-公开固醇调节元件结合蛋白-1表达的反义调制公开(公告)号：US20050215504A1
公开(公告)日：2005-09-29
申请号：US11014360
申请日：2004-12-16
申请人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。
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公开(公告)号：US20050227938A1
公开(公告)日：2005-10-13
申请号：US11015193
申请日：2004-12-17
申请人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
发明人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。
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公开(公告)号：US20050074879A1
公开(公告)日：2005-04-07
申请号：US10773678
申请日：2004-02-06
申请人： James Karras
发明人： James Karras
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K48/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/02 , C12Q1/68
CPC分类号： C12N15/1135 , A61K38/00 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
摘要翻译： 提供化合物，组合物和方法用于抑制人STAT3的表达。 组合物包含靶向编码STAT3的核酸的反义寡核苷酸。 提供了使用这些寡核苷酸抑制STAT3表达和促进细胞凋亡的方法。 还提供了治疗与过表达或STAT3的组成型激活相关的疾病，特别是炎性疾病和癌症的方法。
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