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公开(公告)号：US20110172225A1
公开(公告)日：2011-07-14
申请号：US12680472
申请日：2008-09-25
申请人： James M. Balkovec , Phieng Siliphaivanh , Frances A. Bouffard , Roland A. Bouffard , Michael R. Peel , Weiming Fan , Ahmed Mamai , Sarah Dimick Gray
发明人： James M. Balkovec , Phieng Siliphaivanh , Frances A. Bouffard , Roland A. Bouffard , Michael R. Peel , Weiming Fan , Ahmed Mamai , Sarah Dimick Gray
IPC分类号： A61K31/5377 , C07D311/78 , C07D405/12 , C07D407/12 , C07D413/12 , C07D405/14 , A61K31/352 , A61K31/453 , A61K31/4025 , A61K31/422 , A61K31/4178 , A61K31/496 , A61K31/4545 , A61K31/454 , A61P31/10
CPC分类号： C07J71/0005
摘要： Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
摘要翻译： 本文公开了enfumafungin的新型衍生物及其药学上可接受的盐，水合物和前药。 还公开了包含这种化合物的组合物，制备这些化合物的方法和使用这些化合物作为抗真菌剂和/或（1,3） - ＆bgr-D-葡聚糖合酶抑制剂的方法。 所公开的化合物，其药学上可接受的盐，水合物和前药，以及包含这些化合物，盐，水合物和前药的组合物可用于治疗和/或预防真菌感染和相关疾病和病症。
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公开(公告)号：US08222255B2
公开(公告)日：2012-07-17
申请号：US12680472
申请日：2008-09-25
申请人： James M. Balkovec , Phieng Siliphaivanh , Frances A. Bouffard , Roland A. Bouffard, legal representative , Michael R. Peel , Weiming Fan , Ahmed Mamai , Sarah Dimick Gray
发明人： James M. Balkovec , Phieng Siliphaivanh , Frances A. Bouffard , Michael R. Peel , Weiming Fan , Ahmed Mamai , Sarah Dimick Gray
IPC分类号： C07D311/78 , C07D405/02 , A61K31/352 , A61K31/4025 , A61K31/4433 , A61K31/453 , A61K31/496 , A61K31/506 , A61K31/5355
CPC分类号： C07J71/0005
摘要： Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
摘要翻译： 本文公开了enfumafungin的新型衍生物及其药学上可接受的盐，水合物和前药。 还公开了包含这种化合物的组合物，制备这些化合物的方法和使用这些化合物作为抗真菌剂和/或（1,3） - ＆bgr-D-葡聚糖合酶抑制剂的方法。 所公开的化合物，其药学上可接受的盐，水合物和前药以及包含这些化合物，盐，水合物和前药的组合物可用于治疗和/或预防真菌感染和相关疾病和病症。
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公开(公告)号：US20120004240A1
公开(公告)日：2012-01-05
申请号：US13255785
申请日：2010-03-03
申请人： Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
发明人： Weiming Fan , Thomas F.N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
IPC分类号： A61K31/4985 , A61P35/00 , A61K31/4375 , C07D401/14 , A61K31/519
CPC分类号： C07D471/14 , C07D487/14 , C07D519/00
摘要： The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供抑制Akt活性的取代的稠合萘啶衍生物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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4.发明申请NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY 审中-公开具有NIK抑制活性的新型6-氨基亚氨基嘧啶衍生物公开(公告)号：US20110183975A1
公开(公告)日：2011-07-28
申请号：US13122666
申请日：2009-09-28
申请人： Yasuhiro Goto , Takeshi Sagara , Weiming Fan , Thomas F. N. Hacell , Matthew G. Jenks , Michael J. Malaska , Joseph A. Moore, III , Gilles Ouvry , Bharathi Pandi , Michael R. Peel , Kimberty M. Steward
发明人： Yasuhiro Goto , Takeshi Sagara , Weiming Fan , Thomas F. N. Hacell , Matthew G. Jenks , Michael J. Malaska , Joseph A. Moore, III , Gilles Ouvry , Bharathi Pandi , Michael R. Peel , Kimberty M. Steward
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/506 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to a compound of formula I: wherein: R1 is C1-6 alkyl, C3-8 cycloalkyl, aryl, heterocyclyl, or —COR1x, where the C1-6 alkyl, C3-8 cycloalkyl, aryl, and heterocyclyl may be substituted; and R1x is C3-8 cycloalkyl, aryl, or heterocyclyl, any of which may be substituted; R2, R3, R4, R5, R6, and R7 are each independently hydrogen, halogen, C1-6 alkyl, or aryl, where the C1-6 alkyl or aryl may be substituted; R8 is hydrogen, C1-6 alkyl, aryl, or heterocyclyl, any of which may be substituted; or a pharmaceutically acceptable salt or ester thereof.
摘要翻译： 本发明涉及式I化合物：其中：R 1是C 1-6烷基，C 3-8环烷基，芳基，杂环基或-COR 1 x，其中C 1-6烷基，C 3-8环烷基，芳基和杂环基可以 被替代 并且R1x是C3-8环烷基，芳基或杂环基，其中任何一个可以被取代; R 2，R 3，R 4，R 5，R 6和R 7各自独立地为氢，卤素，C 1-6烷基或芳基，其中C 1-6烷基或芳基可以被取代; R8是氢，C1-6烷基，芳基或杂环基，其中任何一个可以被取代; 或其药学上可接受的盐或酯。
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公开(公告)号：US08614221B2
公开(公告)日：2013-12-24
申请号：US13255785
申请日：2010-03-10
申请人： Weiming Fan , Thomas F. N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
发明人： Weiming Fan , Thomas F. N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
IPC分类号： A61K31/519 , C07D471/12
CPC分类号： C07D471/14 , C07D487/14 , C07D519/00
摘要： The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供抑制Akt活性的取代的稠合萘啶衍生物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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公开(公告)号：US20120204868A1
公开(公告)日：2012-08-16
申请号：US13369730
申请日：2012-02-09
申请人： Jason E. Allan , Michael R. Peel
发明人： Jason E. Allan , Michael R. Peel
摘要： A case for an emergency escape breathing apparatus including a substantially rigid hollow shell defining a cylinder housing portion for retaining a cylinder of breathable gas and a delivery device housing portion for removably housing a delivery device for the breathable gas supplied by the cylinder. An access opening is provided which provides access to the interior of the delivery device housing portion through which a delivery device, such as a hood or mask, can be inserted and removed.
摘要翻译： 一种用于紧急逃逸呼吸器的壳体，包括基本刚性的中空壳体，其限定用于保持气体气囊的气缸容纳部分和用于可移除地容纳由气缸供应的可呼吸气体的输送装置的输送装置壳体部分。 提供进入开口，其提供进入输送装置壳体部分的内部，通过该进入开口可以插入和移除诸如罩或掩模的输送装置。
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公开(公告)号：US5144034A
公开(公告)日：1992-09-01
申请号：US505969
申请日：1990-04-06
IPC分类号： C07D473/00 , C07F7/08
CPC分类号： C07F7/0818 , C07D473/00
摘要： This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent.
摘要翻译： 本发明涉及制备某些光学活性环戊烯衍生物的新方法和用于该方法的新型中间体。 特别地，本发明涉及羰基维生素的1'R-顺式异构体的合成，（1'R-顺式）-2-氨基-1,9-二氢-9- [4-（羟基甲基）-2-环戊烯-1-酮 - 基] -6H-嘌呤-6-酮，抗病毒剂。
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公开(公告)号：US09101788B2
公开(公告)日：2015-08-11
申请号：US13369730
申请日：2012-02-09
申请人： Jason E. Allan , Michael R. Peel
发明人： Jason E. Allan , Michael R. Peel
摘要： A case for an emergency escape breathing apparatus including a substantially rigid hollow shell defining a cylinder housing portion for retaining a cylinder of breathable gas and a delivery device housing portion for removably housing a delivery device for the breathable gas supplied by the cylinder. An access opening is provided which provides access to the interior of the delivery device housing portion through which a delivery device, such as a hood or mask, can be inserted and removed.
摘要翻译： 一种用于紧急逃逸呼吸器的壳体，包括基本刚性的中空壳体，其限定用于保持气体气囊的气缸容纳部分和用于可移除地容纳由气缸供应的可呼吸气体的输送装置的输送装置壳体部分。 提供进入开口，其提供进入输送装置壳体部分的内部，通过该进入开口可以插入和移除诸如罩或掩模的输送装置。
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