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    Saliva sample collection systems
    2.
    发明申请
    Saliva sample collection systems 有权
    唾液样本收集系统

    公开(公告)号：US20120325721A1

    公开(公告)日：2012-12-27

    申请号：US12383535

    申请日：2009-03-25

    申请人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

    发明人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

    IPC分类号： B01L3/00 ,  B65D85/62

    CPC分类号： C12Q1/6806 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/50825 ,  B01L2200/18 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/0867 ,  Y10T436/2575

    摘要： Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.

    摘要翻译： 唾液样本收集系统被配置为特别注意非熟练用户的易用性，并通过常规传送服务（如联邦快递）进行安全的传输和传送。 通过紧密耦合两个主要元件形成密封空腔：接收容器元件和密封帽元件。 接收容器与其结合：立式装置，填充线窗，漏斗系统，刀，螺纹组和容纳管等。 互补盖元件包括协作螺纹组件，标签接收表面，抓握表面，密封装置和具有可撕裂薄膜膜的储存器。 这两个主要元件可以容纳在特定于应用的运输容器中，其支持两种运送模式，由此系统可以以不同的运送模式每次以方式运送给和来自捐赠者的用户。

    Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    6.
    发明授权
    Human neuronal nicotinic acetylcholine receptor compositions and methods employing same 失效
    人神经元烟碱乙酰胆碱受体组合物及其应用方法

    公开(公告)号：US07119067B2

    公开(公告)日：2006-10-10

    申请号：US10349836

    申请日：2003-01-23

    申请人： Kathryn J. Elliott ,  Michael M. Harpold

    发明人： Kathryn J. Elliott ,  Michael M. Harpold

    IPC分类号： C07K14/705

    CPC分类号： G01N33/5008 ,  C07K14/70571 ,  G01N33/566

    摘要： Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for producing alpha and beta subunits are provided. In particular, nucleic acid molecules encoding α6 subunits and molecules encoding β3 subunits of human neuronal nicotinic acetylcholine receptors are provided. In addition, combinations of a plurality of subunits, such as one or more of α1, α2, α3, α4, α5, α6 and/or α7 subunits in combination with one or more of β3 subunits or such as one or more of β2, β3 and/or β4 subunits in combination with an α6 subunit are provided.

    摘要翻译： 提供编码人神经元烟碱乙酰胆碱受体α和β亚基的核酸分子，含有核酸分子的哺乳动物和两栖动物细胞，以及产生α和β亚基的方法。 特别地，提供了编码α6个亚基的核酸分子和编码人神经元烟碱乙酰胆碱受体的β3 N亚基的分子。 此外，多个亚基的组合，例如α1，α2，α3，α3，α3， 4个，α5个，α6个和/或α7个亚基，与β3的一个或多个组合 β亚基或诸如β2，β3和/或β4亚单位中的一个或多个的α亚基， 提供了SUB> 6 亚基。

    Human neuronal nicotinic acetylcholine receptor & subunit methods employing same
    7.
    发明授权
    Human neuronal nicotinic acetylcholine receptor & subunit methods employing same 失效
    人类神经元烟碱乙酰胆碱受体和亚基方法

    公开(公告)号：US06664375B2

    公开(公告)日：2003-12-16

    申请号：US09892985

    申请日：2001-06-27

    申请人： Kathryn J. Elliott ,  Steven B. Ellis ,  Michael M. Harpold

    发明人： Kathryn J. Elliott ,  Steven B. Ellis ,  Michael M. Harpold

    IPC分类号： C07K14705

    CPC分类号： C07K14/70571

    摘要： DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.

    摘要翻译： 提供了编码人神经元烟碱乙酰胆碱受体α和β亚基的DNA，含有DNA的哺乳动物和两栖动物细胞，产生α和β亚基的方法以及分离或基本上纯的α4，α7和β4亚单位。 此外，提供单独表达这些亚单位或与烟碱乙酰胆碱受体的其它亚基组合的细胞和使用细胞的方法。

    Human neuronal nicotinic acetylcholine receptor &agr;6 and &bgr;3 nucleic acid
    8.
    发明授权
    Human neuronal nicotinic acetylcholine receptor &agr;6 and &bgr;3 nucleic acid 失效
    人神经元烟碱乙酰胆碱受体α6和β3核酸

    公开(公告)号：US06485967B1

    公开(公告)日：2002-11-26

    申请号：US08484722

    申请日：1995-06-07

    申请人： Kathryn J. Elliott ,  Michael M. Harpold

    发明人： Kathryn J. Elliott ,  Michael M. Harpold

    IPC分类号： C12N510

    CPC分类号： G01N33/5008 ,  C07K14/70571 ,  G01N33/566

    摘要： DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically &agr;6) and beta subunits (specifically &bgr;3) are provided. In addition, combinations of a plurality of subunits (i.e., one or more of as &agr;1, &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and/or &agr;7 subunits in combination with one or more of &bgr;3 subunits are provided.

    摘要翻译： 编码人类神经元烟碱乙酰胆碱受体α和β亚基的DNA，含有所述DNA的哺乳动物和两栖动物细胞，用于产生α和β亚基和重组（即，分离或基本上纯的）α亚单位（特别是α6）和β亚单位（特别是β3） 被提供。 此外，提供了多个亚基（即，α1，α2，α3，α4，α5，α6和/或α7亚基中的一个或多个与β3亚基中的一个或多个组合的组合）。

    Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    9.
    发明授权
    Human neuronal nicotinic acetylcholine receptor compositions and methods employing same 失效

    公开(公告)号：US06524789B1

    公开(公告)日：2003-02-25

    申请号：US08660451

    申请日：1996-06-07

    申请人： Kathryn J. Elliott ,  Michael M. Harpold

    发明人： Kathryn J. Elliott ,  Michael M. Harpold

    IPC分类号： C12Q168

    CPC分类号： G01N33/5008 ,  C07K14/70571 ,  G01N33/566

    摘要： Nucleic acid molecules encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the nucleic acid molecules, and methods for producing alpha and beta subunits are provided. In particular, nucleic acid molecules encoding &agr;6 subunits and molecules encoding &bgr;3 subunits of human neuronal nicotinic acetylcholine receptors are provided. In addition, combinations of a plurality of subunits, such as one or more of &agr;1, &agr;2, &agr;3, &agr;4, &agr;5, &agr;6 and/or &agr;7 subunits in combination with one or more of &bgr;3 subunits or such as one or more of &bgr;2, &bgr;3 and/or &bgr;4 subunits in combination with an &agr;6 subunit are provided.

    Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
    10.
    发明授权
    Human neuronal nicotinic acetylcholine receptor compositions and methods employing same 失效
    人神经元烟碱乙酰胆碱受体组合物及其应用方法

    公开(公告)号：US06303753B1

    公开(公告)日：2001-10-16

    申请号：US09217345

    申请日：1998-12-21

    申请人： Kathryn J. Elliott ,  Steven B. Ellis ,  Michael M. Harpold

    发明人： Kathryn J. Elliott ,  Steven B. Ellis ,  Michael M. Harpold

    IPC分类号： C07K100

    CPC分类号： C07K14/70571

    摘要： DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.

    摘要翻译： 提供了编码人神经元烟碱乙酰胆碱受体α和β亚基的DNA，含有DNA的哺乳动物和两栖动物细胞，产生α和β亚基的方法以及分离或基本上纯的α4，α7和β4亚单位。 此外，提供单独表达这些亚单位或与烟碱乙酰胆碱受体的其它亚基组合的细胞和使用细胞的方法。