公开(公告)号：US08617487B2

公开(公告)日：2013-12-31

申请号：US12383535

申请日：2009-03-25

申请人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

发明人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

IPC分类号： B01L3/00

CPC分类号： C12Q1/6806 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/50825 ,  B01L2200/18 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/0867 ,  Y10T436/2575

摘要： Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.

公开(公告)号：US20120325721A1

公开(公告)日：2012-12-27

申请号：US12383535

申请日：2009-03-25

申请人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

发明人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

IPC分类号： B01L3/00 ,  B65D85/62

CPC分类号： C12Q1/6806 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/50825 ,  B01L2200/18 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/0867 ,  Y10T436/2575

摘要： Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.

摘要翻译： 唾液样本收集系统被配置为特别注意非熟练用户的易用性，并通过常规传送服务（如联邦快递）进行安全的传输和传送。 通过紧密耦合两个主要元件形成密封空腔：接收容器元件和密封帽元件。 接收容器与其结合：立式装置，填充线窗，漏斗系统，刀，螺纹组和容纳管等。 互补盖元件包括协作螺纹组件，标签接收表面，抓握表面，密封装置和具有可撕裂薄膜膜的储存器。 这两个主要元件可以容纳在特定于应用的运输容器中，其支持两种运送模式，由此系统可以以不同的运送模式每次以方式运送给和来自捐赠者的用户。

公开(公告)号：USD790726S1

公开(公告)日：2017-06-27

申请号：US29314382

申请日：2009-03-25

申请人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliot

设计人： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliot

公开(公告)号：US20120323600A1

公开(公告)日：2012-12-20

申请号：US12387783

申请日：2009-05-07

申请人： James Plante ,  David Becker

发明人： James Plante ,  David Becker

IPC分类号： G06Q50/24

CPC分类号： G16H10/60 ,  G06F16/24564 ,  G06F19/3456 ,  G06Q50/22 ,  G16B50/00

摘要： A drug management system based upon membership genomic data is coupled to cooperating external computing systems via an object server which prepares drug use reports for automated delivery in response to results that data output from the member database. Based on rules stored in a rules library a query engine runs tests on the stored member genetic information to identify and meet specified criteria.

摘要翻译： 基于成员基因组数据的药物管理系统通过对象服务器耦合到协作的外部计算系统，对象服务器响应于从成员数据库输出的数据的结果来准备用于自动传送的药物使用报告。 基于存储在规则库中的规则，查询引擎运行对存储的成员遗传信息的测试以识别并满足指定的标准。

公开(公告)号：US20130164738A1

公开(公告)日：2013-06-27

申请号：US13333883

申请日：2011-12-21

申请人： David Becker ,  James Plante ,  Moreno Tanya ,  Cindy Wang

发明人： David Becker ,  James Plante ,  Moreno Tanya ,  Cindy Wang

IPC分类号： C12Q1/68 ,  C12M1/00

CPC分类号： B01L3/508 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/502 ,  B01L3/50825 ,  B01L99/00 ,  B01L2200/185 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/06 ,  B01L2300/0672 ,  C12N15/1006 ,  C12Q1/6806

摘要： Biological sample collection kits are devised with physical features to enable a high performance collection system which delivers preprocessed biological matter via conventional shipping means to a testing laboratories. In particular, untrained and unskilled users deposit biological matter such as saliva or blood into a receiving vessel. By sealing the container, the user causes release of a premixed solution containing preservatives and optionally lysis reagents. In addition, a purification agent is arranged to bind to target molecules and facilitate their removal from solution. These time consuming processes occur while the sample is in transit to the testing facility such that when it arrives, it is in a preconditioned state immediately ready for execution of washing steps. Thus, the high performance containers taught herein are useful for collection biological samples and performing initial process steps on received matter—steps which are largely effected during the shipping stage of the transfer process.

摘要翻译： 生物样本收集套件设计有物理特征，以实现高性能收集系统，其通过常规运输方式将预处理的生物物质提供给测试实验室。 特别是，未经训练和不熟练的使用者将诸如唾液或血液的生物物质沉积到接收容器中。 通过密封容器，使用者引起含有防腐剂和任选裂解试剂的预混溶液的释放。 此外，将净化剂配置成与靶分子结合并促进它们从溶液中的去除。 这些耗时的过程发生在样品转运到测试设备时，使得当其到达时，它处于预处理状态，立即准备好执行洗涤步骤。 因此，本文中教导的高性能容器对于收集生物样品是有用的，并且在接收的物质步骤上执行初始的处理步骤，这些步骤主要是在转移过程的运输阶段中实现的。

公开(公告)号：US20130018279A1

公开(公告)日：2013-01-17

申请号：US12584153

申请日：2009-09-01

申请人： James Plante ,  Michael Nova ,  David Becker ,  Luke Noaek

发明人： James Plante ,  Michael Nova ,  David Becker ,  Luke Noaek

IPC分类号： A61B5/151

CPC分类号： A61B5/157 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/150022 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150404 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15142 ,  A61B5/6833 ,  A61M37/0015

摘要： Blood sample collection apparatus and kits are devised as easy-to-use, reduced pain devices operable by persons not having medical training or other expertise or knowledge. A flexible strip having adhesives on two portions of a first side accommodate therebetween and absorbent pad and substrate with microstructures. The substrate includes microstructures arranged to gently penetrate or pierce skin and cause a small amount of blood to pass to the external surface of a user's flesh. An absorbent pad receives and absorbs a blood sample therein. The absorbent pad may additionally support a plurality of chemical agents which further advances mobility of blood in the collection system. These chemical agents may include anticoagulants and blood anticlotting agents to facilitate blood transfer from a donor to the absorbent pad. Additionally, these systems may also include a blood preservative to stabilize blood collected for an extended shipping and transfer period. These blood sample collection systems may further include a numbing agent to improve comfort of use.

摘要翻译： 血液采集仪器和试剂盒被设计为易于使用，减少的疼痛装置可由没有医疗培训或其他专业知识或知识的人操作。 在第一侧的两部分上具有粘合剂的柔性条带容纳在其间并具有微结构的吸收垫和基底。 衬底包括布置成轻轻地穿透或刺穿皮肤并导致少量血液传递到使用者肉体的外表面的微结构。 吸收垫接收并吸收血样。 吸收垫可另外支撑多个化学试剂，这进一步提高了收集系统中血液的移动性。 这些化学试剂可以包括抗凝剂和血液抗凝胶剂，以促进从供体到吸收垫的血液转移。 此外，这些系统还可以包括防水剂以稳定在延长的运输和转移期间收集的血液。 这些血液样品收集系统可以进一步包括麻醉剂以改善使用的舒适性。

公开(公告)号：US20130035954A1

公开(公告)日：2013-02-07

申请号：US12387782

申请日：2009-05-07

申请人： James Plante ,  David Becker

发明人： James Plante ,  David Becker

IPC分类号： G06Q50/24

CPC分类号： G06F16/245 ,  G06Q10/00 ,  G16H50/30 ,  G16H50/70

摘要： A computer alert to system and apparatus is arranged about DNA sequence markers whereby the genome of a specific human subject is considered in view of a plurality of discrete rules to affect alerts which may be generated and transmitted in electronic form over standardized e-mail systems (Internet/SMTP protocol for example) to a user workstation which may be equipped with a browser or custom application (includes a special genome viewers, review tools; etc.). Alerting systems described in this disclosure included mechanical/a chemical systems for analyzing a human DNA sample to produce a genomic data set representing genetic indicators or markers on alleles of interest including those as well SNPs associated with important trial traits disease and characteristics. A genome dataset is stored as a portion of a data a record having a one-to-one correspondence with membership in a membership database. A dynamic rules that of its reality of discrete rules provides a query engine with logic which can be executed against membership data stored in accordance with standardized database procedures to produce a genomic result set from which appropriate alerts may be formed in an alert to module computer apparatus. These alerts may be characterized as including multimedia information and they may be prefer to play conveyed to membership with whom the underlying data is associated.

摘要翻译： 针对系统和装置安排关于DNA序列标记的计算机警报，由此考虑到多个离散规则来考虑特定人类受试者的基因组，以影响可以通过标准化电子邮件系统以电子形式产生和传送的警报（ 互联网/ SMTP协议）到可能配备浏览器或定制应用程序的用户工作站（包括特殊的基因组查看器，查看工具等）。 本公开中描述的警报系统包括用于分析人类DNA样品的机械/化学系统，以产生代表感兴趣的等位基因的遗传指标或标志物的基因组数据集，包括与重要的试验性状疾病和特征相关的SNP。 基因组数据集作为数据的一部分存储在与成员数据库中的隶属关系一一对应的记录上。 其离散规则的现实的动态规则为查询引擎提供了可根据标准化数据库过程存储的成员数据执行的逻辑，以产生基因组结果集合，从而可以在模块计算机设备的警报中形成适当的警报 。 这些警报可以被表征为包括多媒体信息，并且他们可能更喜欢播放传达给与基础数据相关联的会员。

公开(公告)号：US08989959B2

公开(公告)日：2015-03-24

申请号：US11593659

申请日：2006-11-07

申请人： James Plante ,  Ramesh Kasavaraju ,  Gregory Mauro ,  Andrew Nickerson

发明人： James Plante ,  Ramesh Kasavaraju ,  Gregory Mauro ,  Andrew Nickerson

IPC分类号： G01M17/00 ,  G06F7/00 ,  G06F19/00 ,  G07C5/08

CPC分类号： G07C5/085 ,  B60W40/08

摘要： Vehicle operator performance history recording and reporting systems include devices and methods of automatically collecting and processing vehicle crash or event data over time to form a driver history report. A driver history report may include many factors to express performance or quality of driver service, and these may be reduced to a single value normalized expression in view of a collection of many drivers. Vehicle event recorders are arranged to capture data relating to a particular event. These vehicle event recorders are further coupled to systems which form an association between collected data and the vehicle operator in command of the vehicle at the event moment. Systems provide means for long-term storage of data particularly data in a structure which preserves the association between a driver and event records attributed to him/her. Special recall operations executed against stored data yields operator performance reporting—including a single value performance score indicative of a vehicle operator's performance and safety history. An analyzer system operates to recall data, particularly data from a plurality of events all associated with a single operator but recorded over an extended period of time. Data is arranged such that other mathematical analysis may be applied independently to various data elements or data “fields” to produce performance metrics and ratios which reflect performance. Together, these factors may each be weighted and summed in accordance with specially devised a formulae including those having a single value solution.

摘要翻译： 车辆操作者履行历史记录和报告系统包括随时间自动收集和处理车辆碰撞或事件数据的装置和方法，以形成驾驶员历史报告。 驱动程序历史报告可能包括许多因素来表达驱动程序服务的性能或质量，鉴于许多驱动程序的集合，这些因素可能会降低到单一值归一化表达式。 车辆事件记录器被安排来捕获与特定事件相关的数据。 这些车辆事件记录器进一步耦合到系统，该系统在事件发生时指示车辆的收集数据和车辆操作者之间形成关联。 系统提供了长期存储数据的方法，特别是在保留驱动程序与归因于他/她的事件记录之间的关联的结构中的数据。 针对存储数据执行的特殊召回操作可提供运营商绩效报告，包括指示车辆操作员的性能和安全历史的单一性能评分。 分析器系统操作以召回数据，特别是来自多个事件的数据，所述事件全部与单个操作者相关联，但是在延长的时间段内被记录。 数据被布置成使得其他数学分析可以独立地应用于各种数据元素或数据“场”，以产生反映性能的性能度量和比率。 一起，这些因素可以根据特别设计的包括具有单值解决方案的公式的公式进行加权和求和。

公开(公告)号：US08649933B2

公开(公告)日：2014-02-11

申请号：US11593682

申请日：2006-11-07

申请人： James Plante ,  Ramesh Kasavaraju ,  Bruce Lightner

发明人： James Plante ,  Ramesh Kasavaraju ,  Bruce Lightner

IPC分类号： G06F7/00

CPC分类号： B60R16/03 ,  B60R11/04 ,  F02P5/02 ,  G07C5/0808 ,  G07C5/12 ,  H04N5/23241 ,  H04N5/77

摘要： Video event recorders are coupled to a vehicle power source via an on-board diagnostic system including its power bus, data bus, and scanner port connector. Video event recorders are provided with a power input arranged in conjunction with a standard ODBII type “D” connector. Systems further include an extension cable between the connector and the vehicle event record to accommodate mounting needs associated with each. In advanced versions, both OBD power and data networks are coupled to the vehicle event recorded such that data relating to vehicle diagnostic systems can be captured in a triggered event along with video data. In addition, some versions are provided with special detection mechanism to determine the use state of a vehicle and adjust application of power accordingly. Thus an “in-use” detector is coupled to the vehicle and/or OBD systems to provide feedback which helps to conserve power and regulate the power connections.

摘要翻译： 视频事件记录器通过包括其电源总线，数据总线和扫描仪端口连接器的车载诊断系统耦合到车辆电源。 视频事件记录器具有与标准ODBII类型“D”连接器一起布置的电源输入。 系统还包括在连接器和车辆事件记录之间的延伸电缆，以适应与每个相关联的安装需求。 在高级版本中，OBD电力和数据网络都被耦合到记录的车辆事件，使得与车辆诊断系统相关的数据可以与触发的事件一起被捕获在视频数据中。 另外，一些版本提供了专门的检测机制来确定车辆的使用状态并相应调整功率的应用。 因此，“使用中”检测器耦合到车辆和/或OBD系统以提供有助于节省功率并调节功率连接的反馈。

公开(公告)号：US20080147267A1

公开(公告)日：2008-06-19

申请号：US11637755

申请日：2006-12-13

申请人： James Plante ,  Ramesh Kasavaraju ,  Gregory Mauro ,  Andrew Nickerson

发明人： James Plante ,  Ramesh Kasavaraju ,  Gregory Mauro ,  Andrew Nickerson

IPC分类号： G01M17/00

CPC分类号： G07C5/008 ,  B60R2021/0027 ,  G07C5/085 ,  G07C5/0891 ,  G07C2205/02

摘要： Exception event recorders and analysis systems include: vehicle mounted sensors arranged as a vehicle event recorder to capture both discrete and non-discrete data; a discretization facility; a database; and an analysis server all coupled together as a computer network. Motor vehicles with video cameras and onboard diagnostic systems capture data when the vehicle is involved in a crash or other anomaly (an ‘event’). In station where interpretation of non-discrete data is rendered, i.e. a discretization facility, captured data is used as a basis for production of supplemental discrete data to further characterize the event. Such interpreted data is joined to captured data and inserted into a database in a structure which is searchable and which supports logical or mathematical analysis by automated machines. A coupled analysis server is arranged to test stored data for prescribed conditions and upon finding such, to initiate further actions appropriate for the detected condition.

摘要翻译： 异常事件记录器和分析系统包括：布置为车辆事件记录器的车载传感器以捕获离散和非离散数据; 离散化设施; 数据库 和一个分析服务器全部耦合在一起作为计算机网络。 当车辆参与碰撞或其他异常事件（“事件”）时，带有摄像机和车载诊断系统的汽车捕获数据。 在呈现非离散数据的解释的站（即，离散化设施）中，捕获的数据被用作产生补充离散数据的基础以进一步表征事件。 这种解释的数据被连接到捕获的数据并以可搜索的结构插入到数据库中，并且其支持通过自动化机器的逻辑或数学分析。 耦合分析服务器被布置成测试存储的数据的规定条件，并且在发现这样的情况下，发起适合于检测到的条件的进一步的动作。