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公开(公告)号：US20090149505A1
公开(公告)日：2009-06-11
申请号：US12279124
申请日：2007-02-06
申请人： James R. Empfield , James J. Folmer , James R. Arnold , Joshua Clayton , Abdelmalik Slassi , Methvin Isaac , Ian Egle , Fupeng Ma
发明人： James R. Empfield , James J. Folmer , James R. Arnold , Joshua Clayton , Abdelmalik Slassi , Methvin Isaac , Ian Egle , Fupeng Ma
IPC分类号： C07D401/10 , A61K31/4439 , A61K31/4035 , C07D209/44 , A61P9/00 , A61P25/00 , A61P25/28 , A61P29/00 , A61P25/08
CPC分类号： C07D209/46 , C07D401/04 , C07D405/04
摘要： Compounds of Formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the description, processes for the preparing such compounds, new intermediates employed in their preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如说明书中所定义，制备此类化合物的方法，其制备中使用的新中间体，含该化合物的药物组合物，以及 化合物治疗。
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公开(公告)号：US08153638B2
公开(公告)日：2012-04-10
申请号：US12861336
申请日：2010-08-23
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/4035 , A61K31/427 , C07D403/14 , C07D403/02 , C07D401/02 , C07D209/44 , C07D417/02
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有 化合物和化合物在治疗中的用途。
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公开(公告)号：US20080227794A1
公开(公告)日：2008-09-18
申请号：US12063007
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/404 , A61P25/00 , C07D209/34 , C07D401/12 , C07D403/02 , C07D417/02 , A61K31/497 , A61K31/4439 , A61K31/427
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R 1，R 2，R 3，R 4，R 4， 5，R 6，R 7，R 8，R 9和n如上定义 在描述中，制备化合物的方法，制备中使用的新中间体，含有该化合物的药物组合物以及该化合物在治疗中的用途。
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公开(公告)号：US20100317674A1
公开(公告)日：2010-12-16
申请号：US12861336
申请日：2010-08-23
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/497 , C07D209/44 , C07D401/12 , C07D401/02 , C07D403/02 , C07D403/14 , C07D417/02 , A61K31/4035 , A61K31/4439 , A61K31/427 , A61P25/28 , A61P25/00 , A61P25/30 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/00 , A61P25/16 , A61P25/08 , A61P25/06 , A61P9/00 , A61P9/10
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有 化合物和化合物在治疗中的用途。
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公开(公告)号：US07807706B2
公开(公告)日：2010-10-05
申请号：US12063007
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/4035 , C07D209/46
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有 化合物和化合物在治疗中的用途。
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6.发明申请SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS 失效取代的葡聚糖及其作为代谢谷氨酸受体电位的用途公开(公告)号：US20090111830A1
公开(公告)日：2009-04-30
申请号：US12063018
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/496 , C07D209/34 , C07D401/14 , A61P25/00 , A61K31/4015
CPC分类号： C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中对式I所定义。 本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。
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公开(公告)号：US20090062282A1
公开(公告)日：2009-03-05
申请号：US11577154
申请日：2005-10-14
申请人： Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
发明人： Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
IPC分类号： A61K31/5377 , C07D239/22 , A61K31/513 , C12N9/99 , A61P25/28 , C07D413/10
CPC分类号： C07D239/47 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10
摘要： This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译： 本发明涉及具有结构式Ia或式Ib的新化合物：（Ia，Ib）及其药学上可接受的盐，互变异构体或体内可水解的前体，组合物及其使用方法。 这些新型化合物提供治疗或预防Abeta相关病理学，如认知障碍，阿尔茨海默病，神经变性和痴呆。
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公开(公告)号：US20080306087A1
公开(公告)日：2008-12-11
申请号：US11997424
申请日：2006-08-03
申请人： James R. Empfield , Michael Laplante , Megan Murphy King , Thomas R. Simpson , Maxime C. Tremblay , James M. Woods , Jingbo Yan
发明人： James R. Empfield , Michael Laplante , Megan Murphy King , Thomas R. Simpson , Maxime C. Tremblay , James M. Woods , Jingbo Yan
IPC分类号： A61K31/496 , A61P3/04 , A61P25/00 , A61P11/00 , A61P1/00 , A61K31/495 , C07D295/104 , C07D403/06 , C07D401/06 , C07D409/06
CPC分类号： C07D295/182 , C07D213/82 , C07D233/70 , C07D295/185 , C07D295/192 , C07D333/38
摘要： The present invention relates to compounds of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）化合物及其制备方法，它们在治疗肥胖，精神病和神经障碍中的应用，其治疗用途的方法和含有它们的药物组合物。
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公开(公告)号：US5510386A
公开(公告)日：1996-04-23
申请号：US212456
申请日：1994-03-11
IPC分类号： A61K31/18 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/63 , A61K31/635 , A61P13/02 , A61P15/00 , C07C311/16 , C07C311/21 , C07C311/29 , C07C311/39 , C07C311/44 , C07C311/46 , C07C323/67 , C07D213/76 , C07D233/56 , C07D249/12 , C07D295/22 , C07D295/26 , C07C311/15
CPC分类号： C07D295/26 , C07C311/29 , C07C311/46
摘要： Compounds of formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A-B have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinery incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
摘要翻译： 式I的化合物其中R1，R2，R3，R4，R5和A-B具有本说明书中给出的任何含义及其药学上可接受的盐可用于治疗尿失禁。 还公开了药物组合物，制备式I化合物和中间体的方法。
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公开(公告)号：US20080214570A1
公开(公告)日：2008-09-04
申请号：US11997438
申请日：2006-08-03
IPC分类号： A61K31/495 , C07D295/26 , A61P25/00 , A61P25/18 , A61P3/04
CPC分类号： C07D295/182 , C07D295/185 , C07D295/192 , C07D295/22
摘要： The present invention relates to compounds of formula I and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式I化合物及其制备方法，它们用于治疗肥胖，精神病和神经障碍，其治疗用途的方法和含有它们的药物组合物。
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