公开(公告)号：US20180136165A1

公开(公告)日：2018-05-17

申请号：US15569822

申请日：2016-04-28

申请人： Jan Hendrikse ,  Vladimir Romanov ,  Udo Verkerk ,  Alan Hopkinson

发明人： Jan Hendrikse ,  Vladimir Romanov ,  Udo Verkerk ,  Alan Hopkinson

IPC分类号： G01N27/64 ,  G01N27/68 ,  H01J49/14

CPC分类号： G01N27/64 ,  G01N27/62 ,  G01N27/622 ,  G01N27/68 ,  H01J49/145

摘要： The present disclosure relates to an ion exchange process, as well as a process and system for detecting nitrates, which employ a class of dopants comprising at least two functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion. In an aspect, the present disclosure provides an ion exchange process for forming a negatively charged nitrate-dopant ion analyte for analysis by a spectrometry analysis instrument, comprising: providing a gas comprising a dopant in both neutral and ionized forms; contacting a nitrate-containing sample with the gas comprising the dopant and thereby desorbing a nitrate ion from the sample to form a negatively charged nitrate-dopant ion analyte and replacing the desorbed nitrate ion with a negatively charged ionized dopant molecule; wherein the dopant is an organic compound comprising two or more carbon atoms and two or more functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion; or the dopant is an organic compound comprising at least two carbon atoms and only a single functional group capable of hydrogen bonding with a nitrate ion, which group is a —COOH functional group, and where the carbon atom of the —COOH functional group is bonded directly to another carbonyl group; and with the proviso that the dopant is not lactic acid, a lactic acid salt or a compound that forms lactate ions upon ionization.

公开(公告)号：US20140033835A1

公开(公告)日：2014-02-06

申请号：US13562762

申请日：2012-07-31

申请人： Jan Hendrikse ,  Vladimir Romanov

发明人： Jan Hendrikse ,  Vladimir Romanov

IPC分类号： G01N1/02

CPC分类号： G01N1/44 ,  G01N2001/002 ,  H01J49/049

摘要： A sample introduction system configured for introducing analytes of a solid phase micro extraction (SPME) sample into an analytical instrument system (e.g., mass spectrometer) is described. The sample introduction system includes a pressure vessel configured with an inlet port via which a probe portion (e.g., SPME fiber) of a SPME assembly is received into a sealed volume of the pressure vessel. The probe portion of the SPME assembly is coated with an extracting phase material, the analytes being absorbed into and/or adsorbed onto the extracting phase material. The pressure vessel is configured for providing an environment in which desorption of the analytes from the extracting phase material occurs at a gaseous pressure which is substantially less than atmospheric pressure (e.g., less than 100 mTorr). The desorbed analytes are then directed to the vacuum chamber of the analytical instrument system via an outlet port of the pressure vessel.

摘要翻译： 描述了配置用于将固相微萃取（SPME）样品的分析物引入分析仪器系统（例如质谱仪）中的样品引入系统。 样品引入系统包括配置有入口的压力容器，SPME组件的探针部分（例如，SPME纤维）经由该入口接收到压力容器的密封体积中。 SPME组件的探针部分涂覆有萃取相材料，分析物被吸收到和/或吸附到萃取相材料上。 压力容器被配置为提供一种环境，其中分析物从萃取相材料中的解吸附在基本上小于大气压（例如小于100mTorr）的气体压力下发生。 解吸的分析物然后通过压力容器的出口导入分析仪器系统的真空室。

公开(公告)号：US09134208B2

公开(公告)日：2015-09-15

申请号：US13562762

申请日：2012-07-31

申请人： Jan Hendrikse ,  Vladimir Romanov

发明人： Jan Hendrikse ,  Vladimir Romanov

IPC分类号： G01N1/44 ,  H01J49/04 ,  G01N1/00

CPC分类号： G01N1/44 ,  G01N2001/002 ,  H01J49/049

摘要： A sample introduction system configured for introducing analytes of a solid phase micro extraction (SPME) sample into an analytical instrument system (e.g., mass spectrometer) is described. The sample introduction system includes a pressure vessel configured with an inlet port via which a probe portion (e.g., SPME fiber) of a SPME assembly is received into a sealed volume of the pressure vessel. The probe portion of the SPME assembly is coated with an extracting phase material, the analytes being absorbed into and/or adsorbed onto the extracting phase material. The pressure vessel is configured for providing an environment in which desorption of the analytes from the extracting phase material occurs at a gaseous pressure which is substantially less than atmospheric pressure (e.g., less than 100 mTorr). The desorbed analytes are then directed to the vacuum chamber of the analytical instrument system via an outlet port of the pressure vessel.

摘要翻译： 描述了配置用于将固相微萃取（SPME）样品的分析物引入分析仪器系统（例如质谱仪）中的样品引入系统。 样品引入系统包括配置有入口的压力容器，SPME组件的探针部分（例如，SPME纤维）经由该入口接收到压力容器的密封体积中。 SPME组件的探针部分涂覆有萃取相材料，分析物被吸收到和/或吸附到萃取相材料上。 压力容器被配置为提供一种环境，其中分析物从萃取相材料中的解吸附在基本上小于大气压（例如小于100mTorr）的气体压力下发生。 解吸的分析物然后通过压力容器的出口导入分析仪器系统的真空室。

公开(公告)号：US07750312B2

公开(公告)日：2010-07-06

申请号：US11680196

申请日：2007-02-28

申请人： John J. Corr ,  Jan Hendrikse

发明人： John J. Corr ,  Jan Hendrikse

IPC分类号： H01J27/24 ,  H01J49/00 ,  B01D59/44

CPC分类号： H01J49/164 ,  H01J49/067

摘要： An apparatus and method is disclosed for reducing contamination in a mass spectrometer instrument system. The system includes an ion source at a first pressure for generating ions by laser desorption/ionization and an inlet aperture to a vacuum chamber at a second, lower pressure than the first pressure of the ion source. A sample plate within the ion source supports a sample deposited thereon and a laser can be configured to generate laser pulses striking at least a portion of the sample at an angle of incidence from about 0 to about 80 degrees to the center line of a first ion optical axis of a mass analyzer, producing a plume. A combination of the angle of incidence of the laser pulses and the distance between the sample plate and the inlet region aperture can reduce neutral contaminants in the plume from being drawn into the inlet aperture.

摘要翻译： 公开了用于减少质谱仪仪器系统中的污染的装置和方法。 该系统包括在第一压力下的离子源，用于通过激光解吸/电离产生离子，以及在比离子源的第一压力低的第二，低于第二压力的真空室的入口孔。 离子源内的样品板支持沉积在其上的样品，并且激光器可以被配置为产生激光脉冲，该激光脉冲以与第一离子的中心线成约0至约80度的入射角产生至少一部分样品 质量分析器的光轴，产生羽流。 激光脉冲的入射角与样品板与入口区域孔之间的距离的组合可以减少羽流中的中性污染物被吸入入口孔。

公开(公告)号：US20080067409A1

公开(公告)日：2008-03-20

申请号：US11680196

申请日：2007-02-28

申请人： John J. Corr ,  Jan Hendrikse

发明人： John J. Corr ,  Jan Hendrikse

IPC分类号： H01J27/24

CPC分类号： H01J49/164 ,  H01J49/067

摘要： An apparatus and method is disclosed for reducing contamination in a mass spectrometer instrument system. The system includes an ion source at a first pressure for generating ions by laser desorption/ionization and an inlet aperture to a vacuum chamber at a second, lower pressure than the first pressure of the ion source. A sample plate within the ion source supports a sample deposited thereon and a laser can be configured to generate laser pulses striking at least a portion of the sample at an angle of incidence from about 0 to about 80 degrees to the center line of a first ion optical axis of a mass analyzer, producing a plume. A combination of the angle of incidence of the laser pulses and the distance between the sample plate and the inlet region aperture can reduce neutral contaminants in the plume from being drawn into the inlet aperture.

摘要翻译： 公开了用于减少质谱仪仪器系统中的污染的装置和方法。 该系统包括在第一压力下的离子源，用于通过激光解吸/电离产生离子，以及在比离子源的第一压力低的第二，低于第二压力的真空室的入口孔。 离子源内的样品板支持沉积在其上的样品，并且激光器可以被配置为产生激光脉冲，该激光脉冲以与第一离子的中心线成约0至约80度的入射角产生至少一部分样品 质量分析器的光轴，产生羽流。 激光脉冲的入射角与样品板与入口区域孔之间的距离的组合可以减少羽流中的中性污染物被吸入入口孔。