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    Multidimensional Nmr Spectroscopy of A Hyperpolarized Sample
    4.
    发明申请
    Multidimensional Nmr Spectroscopy of A Hyperpolarized Sample 有权
    超极化样品的多维Nmr光谱

    公开(公告)号：US20080061781A1

    公开(公告)日：2008-03-13

    申请号：US10553381

    申请日：2004-04-13

    申请人： Rolf Servin ,  Jan Henrik Ardenkjaer-Larsen ,  Haukur Johannesson ,  Maurice Goldman ,  Jan Wolber

    发明人： Rolf Servin ,  Jan Henrik Ardenkjaer-Larsen ,  Haukur Johannesson ,  Maurice Goldman ,  Jan Wolber

    IPC分类号： G01R33/46

    CPC分类号： G01R33/4633 ,  G01R33/62

    摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analysing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.

    摘要翻译： 本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。 所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。

    Multidimensional NMR spectroscopy of a hyperpolarized sample
    5.
    发明授权
    Multidimensional NMR spectroscopy of a hyperpolarized sample 有权
    超极化样品的多维NMR光谱

    公开(公告)号：US07550970B2

    公开(公告)日：2009-06-23

    申请号：US10553381

    申请日：2004-04-13

    申请人： Rolf Servin ,  Jan Henrik Ardenkjaer-Larsen ,  Haukur Johannesson ,  Maurice Goldman ,  Jan Wolber

    发明人： Rolf Servin ,  Jan Henrik Ardenkjaer-Larsen ,  Haukur Johannesson ,  Maurice Goldman ,  Jan Wolber

    IPC分类号： G01V3/00

    CPC分类号： G01R33/4633 ,  G01R33/62

    摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analyzing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.

    摘要翻译： 本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。 所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。

    Process for preparation of MR contrast agents
    6.
    发明授权
    Process for preparation of MR contrast agents 有权
    制备MR造影剂的方法

    公开(公告)号：US06872380B2

    公开(公告)日：2005-03-29

    申请号：US09990537

    申请日：2001-11-16

    申请人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    发明人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    IPC分类号： A61K49/00 ,  A61K49/18 ,  C07C67/303 ,  C07C69/675 ,  G01R33/28 ,  G01R33/483 ,  A61B5/055 ,  C07C69/02

    CPC分类号： A61K49/1815

    摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.

    摘要翻译： 本发明提供一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述溶液 以液滴形式进入含有富氢对氢（对 - 氢）和/或邻 - 氘（o- 2 H 2）的氢气（H 2）和/或邻 - 氘（o- 2 H 2）的室中，由此氢化所述基底以形成氢化显像剂 iii）任选地使所述氢化显像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述成像剂在所述 水性介质; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和任选地将所述显像剂的溶液冷冻在所述水性介质中。

    Process
    7.
    发明申请
    Process 有权
    处理

    公开(公告)号：US20050152840A1

    公开(公告)日：2005-07-14

    申请号：US11002864

    申请日：2004-12-02

    申请人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    发明人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    IPC分类号： A61K49/00 ,  A61K49/18 ,  C07C67/303 ,  C07C69/675 ,  G01R33/28 ,  G01R33/483

    CPC分类号： A61K49/1815

    摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.

    摘要翻译： 本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢的氢气（H 2 S 2 H 2）的室中， ）和/或邻 - 氘（o-2 H 2 H 2），由此氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

    Process for preparation of MR contrast agents
    8.
    发明授权
    Process for preparation of MR contrast agents 有权
    制备MR造影剂的方法

    公开(公告)号：US07459144B2

    公开(公告)日：2008-12-02

    申请号：US11002864

    申请日：2004-12-02

    申请人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    发明人： Oskar Axelsson ,  Charlotte Olofsson ,  Axel Morgenstjerne ,  Georg Hansson ,  Haukur Johannesson ,  Jan-Henrik Ardenkjaer-Larsen

    IPC分类号： A61B5/055 ,  B01J10/00

    CPC分类号： A61K49/1815

    摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.

    摘要翻译： 本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢（p-1H 2）和/或邻 - 氘（o-2H 2）的氢气（H 2）的室中，从而氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。