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18 条记录 (耗时 0.04 秒)

    Packaging unit for continuously producing sealed packages, containing pourable food products, from a tube of packaging material
    7.
    发明授权
    Packaging unit for continuously producing sealed packages, containing pourable food products, from a tube of packaging material 失效
    包装单元，用于从包装材料管连续生产包含可倾倒食品的密封包装

    公开(公告)号：US6035615A

    公开(公告)日：2000-03-14

    申请号：US94693

    申请日：1998-06-15

    申请人： Lennart Hansson ,  Felix Dunge

    发明人： Lennart Hansson ,  Felix Dunge

    IPC分类号： B65B55/04 ,  B65B9/087 ,  B65B51/26 ,  B65B51/30 ,  B65B9/06

    CPC分类号： B29C66/1122 ,  B29C65/18 ,  B29C66/4312 ,  B29C66/81427 ,  B29C66/82263 ,  B29C66/83533 ,  B29C66/849 ,  B65B51/30 ,  B29L2031/7166

    摘要： A packaging unit (1) for continuously producing aseptic sealed packages (2), containing a pourable food product, from a tube (14) of packaging material filled with the food product; the unit (1) has a first and second chain conveyor (10, 11) respectively having a number of jaws (12) and a number of counter-jaws (13), which interact with and grip the tube (14) to heat-seal the tube at successive cross sections by means of induction heating elements (29) on the jaws (12); and the jaws (12) and counter-jaws (13) are guided along respective work paths by pairs of cams (50, 51) having different profiles for controlling interaction of the jaws (12) and counter-jaws (13) with the tube (14) of packaging material.

    摘要翻译： 一种用于从填充有食品的包装材料的管（14）连续生产含有可倾倒食品的无菌密封包装（2）的包装单元（1） 单元（1）具有分别具有多个钳口（12）和多个反向钳口（13）的第一和第二链条输送器（10,11），其与管子（14）相互作用并且夹紧管子（14） 通过夹爪（12）上的感应加热元件（29）在连续的横截面处密封管子; 并且通过成对的具有不同轮廓的凸轮（50,51）沿对应的工作路径引导夹爪（12）和反向夹爪（13），以控制夹爪（12）和反向夹爪（13）与管 （14）包装材料。

    Recombinant stratum corneum chymotryptic enzyme (SCCE)
    8.
    发明授权
    Recombinant stratum corneum chymotryptic enzyme (SCCE) 有权
    重组角质层糜蛋白酶（SCCE）

    公开(公告)号：US5981256A

    公开(公告)日：1999-11-09

    申请号：US154344

    申请日：1998-09-16

    申请人： Torbjorn Egelrud ,  Lennart Hansson

    发明人： Torbjorn Egelrud ,  Lennart Hansson

    IPC分类号： C12N15/09 ,  A61K8/00 ,  A61K8/64 ,  A61K8/72 ,  A61K38/00 ,  A61K38/46 ,  A61K38/48 ,  A61P17/00 ,  A61P17/12 ,  A61P29/00 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/10 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N9/76 ,  C12N15/57 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/37 ,  C12Q1/68 ,  C12N15/70 ,  C12N15/85

    CPC分类号： A61Q19/10 ,  A61K8/64 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q5/02 ,  A61Q5/12 ,  C07K16/40 ,  C12N9/6424 ,  A61K2800/86 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention relates to a polypeptide having the amino acid sequence SEQ ID NO:2 or an analogue or variant thereof having SCCE activity as defined in the present application, such as a polypeptide having a sub-sequence of the amino acid sequence SEQ ID NO:2. Furthermore, the present invention relates to nucleotide sequences encoding polypeptides having SCCE activity as well as to expression systems, expression vectors, plasmids and non-human organisms comprising said nucleotide sequences. Important aspects of the present invention relate to pharmaceutical, cosmetic and skin care compositions comprising a polypeptide having SCCE activity, and the use of a polypeptide having SCCE activity for the treatment or prophylaxis of various diseases such as acne, xeroderma or other hyperkeratotic conditions such as callosities and keratosis pilaris as well as the various ichthyoses, psoriasis and other inflammatory skin diseases such as eczemas. Moreover, the present invention relates to the use of a compound which has an inhibitory effect on the enzymatic activity of native SCCE for the manufacture of a pharmaceutical composition for treatment or prophylaxis of autoimmune pemphigus diseases or acantholytic diseases such as familiar pemphigus and Darier's disease.

    摘要翻译： 本发明涉及具有本申请定义的具有SCCE活性的氨基酸序列SEQ ID NO：2的多肽或其具有SCCE活性的类似物或变体，例如具有氨基酸序列SEQ ID NO ：2。 此外，本发明涉及编码具有SCCE活性的多肽的核苷酸序列以及包含所述核苷酸序列的表达系统，表达载体，质粒和非人生物。 本发明的重要方面涉及包含具有SCCE活性的多肽的药物，化妆品和皮肤护理组合物，以及使用具有SCCE活性的多肽来治疗或预防各种疾病，例如痤疮，干燥性皮炎或其它角化过度症状，例如 胼los体和角化病，以及各种鱼鳞病，牛皮癣和其它炎性皮肤疾病如湿疹。 此外，本发明涉及对天然SCCE的酶活性具有抑制作用的化合物的用途，用于制备用于治疗或预防自身免疫性天疱疮病或诸如熟悉的天疱疮和达里氏病的棘皮变性疾病的药物组合物。

    Fibrinolytic enzymes
    9.
    发明授权
    Fibrinolytic enzymes 失效
    纤维蛋白溶解酶

    公开(公告)号：US06682733B1

    公开(公告)日：2004-01-27

    申请号：US08653104

    申请日：1996-05-24

    申请人： Gunnar Pohl ,  Lennart Hansson ,  Björn Löwenadler

    发明人： Gunnar Pohl ,  Lennart Hansson ,  Björn Löwenadler

    IPC分类号： A61K3848

    CPC分类号： C12N9/6459 ,  A61K2123/00 ,  C12Y304/21069

    摘要： A fibrinolytically active plasminogen activator of the tissue type, wherein the growth factor (G) domain has been deleted, and wherein also the K1 domain has been deleted and additionally has been modified in one or more of the following sites or region: the sites of amino acid residues 177, 184, 277 and 448 and the F domain, the F domain modification if present being a deletion of part or all of said domain; DNA-sequence comprising a nucleotide sequence coding for said plasminogen activator; expression vector which in a transformed host cell can express said DNA-sequence; host cell transformed using such vector; pharmaceutical composition comprising the fibrinolytically active plasminogen activator; plasminogen activator for use in treating thrombotic disease; a process for the manufacture of such fibrinolytically active plasminogen activator; a process for the treatment of thrombotic disorder; and a process of localizing thrombi while using such plasminogen activator.

    摘要翻译： 组织类型的纤维蛋白溶解活性纤溶酶原激活剂，其中生长因子（G）结构域已经被缺失，并且其中K1结构域已经被删除并且另外已经在以下一个或多个位点或区域被修饰： 氨基酸残基177,184,277和448以及F结构域，F域修饰如果存在的话是部分或全部所述结构域的缺失;包含编码所述纤溶酶原激活物的核苷酸序列的DNA序列; 转化的宿主细胞可以表达所述DNA序列;使用这种载体转化的宿主细胞;包含纤维蛋白溶解活性纤溶酶原激活剂的药物组合物;用于治疗血栓形成疾病的纤溶酶原激活剂;制备这种纤维蛋白溶解活性纤溶酶原激活剂的方法; 治疗血栓性疾病; 以及使用这种纤溶酶原激活剂定位血栓的过程。

    Transgenic non-human mammal expressing the DNA sequence encoding kappa casein mammary gland and milk
    10.
    发明授权
    Transgenic non-human mammal expressing the DNA sequence encoding kappa casein mammary gland and milk 失效
    表达编码k酪蛋白乳腺和牛奶的DNA序列的转基因非人哺乳动物

    公开(公告)号：US06222094B1

    公开(公告)日：2001-04-24

    申请号：US08256799

    申请日：1994-12-06

    申请人： Lennart Hansson ,  Mats Strömqvist ,  Sven Bergström ,  Olle Hernell ,  Jan Törnell

    发明人： Lennart Hansson ,  Mats Strömqvist ,  Sven Bergström ,  Olle Hernell ,  Jan Törnell

    IPC分类号： A01K67027

    CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/10 ,  A01K2227/101 ,  A01K2227/105 ,  A01K2267/01 ,  A23C9/20 ,  C07K14/4732 ,  C12N15/85 ,  C12N2830/002 ,  C12N2830/85 ,  C12N2840/44

    摘要： The present invention relates to an expression system comprising a DNA sequence encoding a polypeptide which ha a biological activity of human &kgr;-casein, the system comprising a 5′-flanking sequence capable of mediating expression of said DNA sequence. In preferred embodiments the 5′-flanking sequence is from a milk protein gene of a mammal such as a casein gene or whey acidic protein (WAP) gene and the DNA sequence contains at least one intron sequence. The invention further relates to DNA sequences, replicable expression vectors and cells harboring said vectors, recombinant polypeptide e.g. in glycosylated form, and milk, infant formula or nutrient supplement comprising recombinant polypeptide. The invention also relates to a method for producing a transgenic non-human mammal comprising injecting an expression system as defined above and optionally a further DNA encoding &bgr;-casein or an analog, variant or subsequence thereof into a fertilized egg or a cell of an embryo of a mammal so as to incorporate the expression system into the germline of the mammal and developing the resulting injected fertilized egg or embryo into an adult female mammal. In one embodiment, the endogenous polypeptide expressing capability of the mammal is destroyed and/or replaced with the expression system defined above. The invention further relates to a transgenic non-human mammal such as a mouse, rat, rabbit, goat, sheep, pig, lama, camel or bovine species whose germ cells a somatic cells contain a DNA sequence as defined above as a result of chromosomal incorporation into the non-human mammalian genome, or into the genome of an ancestor of said non-human mammal.

    摘要翻译： 本发明涉及包含编码具有人κ-酪蛋白的生物活性的多肽的DNA序列的表达系统，该系统包含能够介导所述DNA序列表达的5'-侧翼序列。 在优选的实施方案中，5'-侧翼序列来自哺乳动物的乳蛋白基因，例如酪蛋白基因或乳清酸性蛋白（WAP）基因，并且DNA序列含有至少一个内含子序列。 本发明还涉及DNA序列，可复制表达载体和携带所述载体的细胞，重组多肽例如 糖基化形式，以及包含重组多肽的乳，婴儿配方食品或营养补充剂。 本发明还涉及一种用于产生转基因非人哺乳动物的方法，包括将如上定义的表达系统和任选的编码β-酪蛋白或其类似物，变体或亚序列的另外的DNA注射入受精卵或胚胎细胞 以将表达系统并入哺乳动物的种系，并将所得的注射的受精卵或胚胎发育成成年雌性哺乳动物。 在一个实施方案中，表达哺乳动物的内源多肽被破坏和/或用上述定义的表达系统代替。 本发明还涉及一种转基因非人哺乳动物，例如小鼠，大鼠，兔，山羊，绵羊，猪，羔羊，骆驼或牛，其生殖细胞体细胞含有如上文所定义的DNA序列作为染色体 掺入非人哺乳动物基因组中，或并入所述非人哺乳动物的祖先的基因组中。