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1.发明授权Stent designs which enable the visibility of the inside of the stent during MRI 失效支架设计，使支架在MRI内部的可视性公开(公告)号：US07479157B2
公开(公告)日：2009-01-20
申请号：US10636063
申请日：2003-08-07
IPC分类号： A61M29/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2250/0043 , A61F2250/0045 , A61F2250/0091
摘要： A medical device that inhibits distortion of medical resonance images taken of the device. In particular, various structures are utilized to allow visibility proximate, and inside of, a tubular member, such as a stent. In one embodiment, the stent is constructed such that any closed path encircling at least a circumference of the stent will pass through at least two materials to reduce or eliminate electrical loops formed in the stent.
摘要翻译： 一种抑制设备拍摄的医用共振图像变形的医疗装置。 特别地，使用各种结构来允许诸如支架之类的管状构件附近和内部的可见性。 在一个实施例中，支架被构造成使得环绕支架的至少圆周的任何封闭路径将穿过至少两种材料以减少或消除在支架中形成的电回路。
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2.发明申请STENT DESIGNS WHICH ENABLE THE VISIBILITY OF THE INSIDE OF THE STENT DURING MRI 审中-公开在MRI中使用STENT设计可以使得椎间盘内窥镜的可视性公开(公告)号：US20090125099A1
公开(公告)日：2009-05-14
申请号：US12353781
申请日：2009-01-14
申请人： Jan Weber , Thomas J. Holman , James Heggestuen
发明人： Jan Weber , Thomas J. Holman , James Heggestuen
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2250/0043 , A61F2250/0045 , A61F2250/0091
摘要： A medical device that inhibits distortion of medical resonance images taken of the device. In particular, various structures are utilized to allow visibility proximate, and inside of, a tubular member, such as a stent. In one embodiment, the stent is constructed such that any closed path encircling at least a circumference of the stent will pass through at least two materials to reduce or eliminate electrical loops formed in the stent.
摘要翻译： 一种抑制设备拍摄的医用共振图像变形的医疗装置。 特别地，使用各种结构来允许诸如支架之类的管状构件附近和内部的可见性。 在一个实施例中，支架被构造成使得环绕支架的至少圆周的任何封闭路径将穿过至少两种材料以减少或消除在支架中形成的电回路。
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3.发明申请Stent designs which enable the visibility of the inside of the stent during MRI 失效支架设计，使支架在MRI内部的可视性公开(公告)号：US20050033407A1
公开(公告)日：2005-02-10
申请号：US10636063
申请日：2003-08-07
申请人： Jan Weber , Thomas Holman , James Heggestuen
发明人： Jan Weber , Thomas Holman , James Heggestuen
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2250/0043 , A61F2250/0045 , A61F2250/0091
摘要： A medical device that inhibits distortion of medical resonance images taken of the device. In particular, various structures are utilized to allow visibility proximate, and inside of, a tubular member, such as a stent. In one embodiment, the stent is constructed such that any closed path encircling at least a circumference of the stent will pass through at least two materials to reduce or eliminate electrical loops formed in the stent.
摘要翻译： 一种抑制设备拍摄的医用共振图像变形的医疗装置。 特别地，使用各种结构来允许诸如支架之类的管状构件附近和内部的可见性。 在一个实施例中，支架被构造成使得环绕支架的至少圆周的任何封闭路径将穿过至少两种材料以减少或消除在支架中形成的电回路。
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公开(公告)号：US20050149176A1
公开(公告)日：2005-07-07
申请号：US10750579
申请日：2003-12-29
申请人： James Heggestuen , Thomas Holman , Jan Weber
发明人： James Heggestuen , Thomas Holman , Jan Weber
CPC分类号： A61L29/14 , A61F2/88 , A61F2/90 , A61F2/945 , A61F2002/072 , A61M25/0012 , A61M25/0041 , A61M25/005 , A61M2025/0063
摘要： Methods of forming support layers for use in catheters using having a support layer included, and stents incorporating coatings of photosensitive polymerizable resins and stents including fibers coated with photosensitive polymerizable resins. A fiber is coated with a PPC resin and incorporated into a support structure for a catheter. Portions of the PPC are polymerized by exposure to light of a desired wavelength, causing increased rigidity and strength to the polymerized portions. As the PPC is polymerized, the fibers coated by the PPC resins become stronger and change the flexibility of devices incorporating such fibers. Additional embodiments include stents incorporating PPC coatings and methods of using such stents, including polymerizing a PPC coating after inserting a self-expanding or balloon-expandable stent.
摘要翻译： 使用包含支撑层的导管形成支撑层的方法，以及包含光敏聚合树脂和支架涂层的支架，包括用光敏聚合树脂涂覆的纤维。 纤维被涂覆有PPC树脂并结合到用于导管的支撑结构中。 PPC的部分通过暴露于所需波长的光而聚合，导致聚合部分的刚性和强度增加。 当PPC聚合时，由PPC树脂涂覆的纤维变得更强，并且改变掺入这种纤维的装置的柔性。 另外的实施方案包括掺入PPC涂层的支架和使用这种支架的方法，包括在插入自扩张或球囊可扩张的支架之后聚合PPC涂层。
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公开(公告)号：US20080091259A1
公开(公告)日：2008-04-17
申请号：US11955098
申请日：2007-12-12
申请人： James Heggestuen , Thomas Holman , Jan Weber
发明人： James Heggestuen , Thomas Holman , Jan Weber
IPC分类号： A61F2/06
CPC分类号： A61L29/14 , A61F2/88 , A61F2/90 , A61F2/945 , A61F2002/072 , A61M25/0012 , A61M25/0041 , A61M25/005 , A61M2025/0063
摘要： Methods of forming support layers for use in catheters using having a support layer included, and stents incorporating coatings of photosensitive polymerizable resins and stents including fibers coated with photosensitive polymerizable resins. A fiber is coated with a PPC resin and incorporated into a support structure for a catheter. Portions of the PPC are polymerized by exposure to light of a desired wavelength, causing increased rigidity and strength to the polymerized portions. As the PPC is polymerized, the fibers coated by the PPC resins become stronger and change the flexibility of devices incorporating such fibers. Additional embodiments include stents incorporating PPC coatings and methods of using such stents, including polymerizing a PPC coating after inserting a self-expanding or balloon-expandable stent.
摘要翻译： 使用包含支撑层的导管形成支撑层的方法，以及包含光敏聚合树脂和支架涂层的支架，包括用光敏聚合树脂涂覆的纤维。 纤维被涂覆有PPC树脂并结合到用于导管的支撑结构中。 PPC的部分通过暴露于所需波长的光而聚合，导致聚合部分的刚性和强度增加。 当PPC聚合时，由PPC树脂涂覆的纤维变得更强，并且改变掺入这种纤维的装置的柔性。 另外的实施方案包括掺入PPC涂层的支架和使用这种支架的方法，包括在插入自扩张或球囊可扩张的支架之后聚合PPC涂层。
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公开(公告)号：US08586072B2
公开(公告)日：2013-11-19
申请号：US11983796
申请日：2007-11-09
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.
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公开(公告)号：US20110130829A1
公开(公告)日：2011-06-02
申请号：US13000594
申请日：2009-06-19
申请人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
发明人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译： 本发明涉及可植入或可插入的医疗装置，其包括基质和含有一种或多种治疗剂的一种或多种含治疗剂的区域。 在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。 本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。
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8.发明申请MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION 审中-公开具有用于控制扩散的金属颗粒组合物的医疗装置公开(公告)号：US20090081272A1
公开(公告)日：2009-03-26
申请号：US11860233
申请日：2007-09-24
申请人： John Clarke , David McMorrow , Aiden Flanagan , Tim O'Connor , Jan Weber , Barry J. O'Brien
发明人： John Clarke , David McMorrow , Aiden Flanagan , Tim O'Connor , Jan Weber , Barry J. O'Brien
IPC分类号： A61F2/00
CPC分类号： A61L31/022 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject.
摘要翻译： 提供了一种植入式或可插入的医疗装置，其包括作为部件：（a）底物组分，其包含至少部分地填充有包含第一治疗剂的含治疗剂的材料的凹陷，和（b）处理的颗粒组合物 在凹陷中，使得在将装置植入或插入到受试者中时，其调节化学物质在装置的凹陷和外部之间的运输。
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9.发明申请公开(公告)号：US20090123521A1
公开(公告)日：2009-05-14
申请号：US11983796
申请日：2007-11-09
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
IPC分类号： A61F2/00 , A61K31/337 , A61N1/04
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.
摘要翻译： 根据本发明的一个方面，提供了医疗装置，其包括设置在包括基底的结构的至少一部分上的纳米颗粒衍生的无机层，以及任选地，设置在至少一部分上的治疗剂含有层 的基底。 在一些实施方案中，无机层是纳米多孔无机层。 本发明的其它方面包括用于形成这种医疗装置的方法。
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公开(公告)号：US09533078B2
公开(公告)日：2017-01-03
申请号：US13000594
申请日：2009-06-19
申请人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
发明人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
IPC分类号： A61F2/06 , A61L31/16 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/14 , A61F2/82
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译： 本发明涉及可植入或可插入的医疗装置，其包括基质和含有一种或多种治疗剂的一种或多种含治疗剂的区域。 在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。 本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。
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