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1.发明申请公开(公告)号：US20090123521A1
公开(公告)日：2009-05-14
申请号：US11983796
申请日：2007-11-09
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
IPC分类号： A61F2/00 , A61K31/337 , A61N1/04
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.
摘要翻译： 根据本发明的一个方面，提供了医疗装置，其包括设置在包括基底的结构的至少一部分上的纳米颗粒衍生的无机层，以及任选地，设置在至少一部分上的治疗剂含有层 的基底。 在一些实施方案中，无机层是纳米多孔无机层。 本发明的其它方面包括用于形成这种医疗装置的方法。
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公开(公告)号：US08586072B2
公开(公告)日：2013-11-19
申请号：US11983796
申请日：2007-11-09
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.
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公开(公告)号：US20110130829A1
公开(公告)日：2011-06-02
申请号：US13000594
申请日：2009-06-19
申请人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
发明人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译： 本发明涉及可植入或可插入的医疗装置，其包括基质和含有一种或多种治疗剂的一种或多种含治疗剂的区域。 在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。 本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。
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公开(公告)号：US09533078B2
公开(公告)日：2017-01-03
申请号：US13000594
申请日：2009-06-19
申请人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
发明人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
IPC分类号： A61F2/06 , A61L31/16 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/14 , A61F2/82
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译： 本发明涉及可植入或可插入的医疗装置，其包括基质和含有一种或多种治疗剂的一种或多种含治疗剂的区域。 在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。 本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。
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5.发明申请MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION 审中-公开具有用于控制扩散的金属颗粒组合物的医疗装置公开(公告)号：US20090081272A1
公开(公告)日：2009-03-26
申请号：US11860233
申请日：2007-09-24
申请人： John Clarke , David McMorrow , Aiden Flanagan , Tim O'Connor , Jan Weber , Barry J. O'Brien
发明人： John Clarke , David McMorrow , Aiden Flanagan , Tim O'Connor , Jan Weber , Barry J. O'Brien
IPC分类号： A61F2/00
CPC分类号： A61L31/022 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject.
摘要翻译： 提供了一种植入式或可插入的医疗装置，其包括作为部件：（a）底物组分，其包含至少部分地填充有包含第一治疗剂的含治疗剂的材料的凹陷，和（b）处理的颗粒组合物 在凹陷中，使得在将装置植入或插入到受试者中时，其调节化学物质在装置的凹陷和外部之间的运输。
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公开(公告)号：US08431149B2
公开(公告)日：2013-04-30
申请号：US12072672
申请日：2008-02-27
申请人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
发明人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0036 , A61F2250/0068 , B33Y80/00
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable stent, such as an intravascular stent, having a coating comprising an inorganic or ceramic oxide, metal or inert carbon and a plurality of reservoirs in such material that contain a therapeutic agent.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。 特别地，本发明涉及可植入支架，例如血管内支架，其具有包含无机或陶瓷氧化物，金属或惰性碳的涂层以及含有治疗剂的这种材料中的多个储存器。
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7.发明授权公开(公告)号：US08070797B2
公开(公告)日：2011-12-06
申请号：US12072666
申请日：2008-02-27
申请人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
发明人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗 装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。
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公开(公告)号：US20080241218A1
公开(公告)日：2008-10-02
申请号：US12072672
申请日：2008-02-27
申请人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
发明人： David McMorrow , Barry Heaney , Anthony Malone , Aiden Flanagan , Tim O'Connor
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0036 , A61F2250/0068 , B33Y80/00
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable stent, such as an intravascular stent, having a coating comprising an inorganic or ceramic oxide, metal or inert carbon and a plurality of reservoirs in such material that contain a therapeutic agent.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。 特别地，本发明涉及可植入支架，例如血管内支架，其具有包含无机或陶瓷氧化物，金属或惰性碳的涂层以及包含治疗剂的这种材料中的多个储存器。
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9.发明申请公开(公告)号：US20080243231A1
公开(公告)日：2008-10-02
申请号：US12072666
申请日：2008-02-27
申请人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
发明人： Aiden Flanagan , David McMorrow , Anthony Malone , Tim O'Connor
CPC分类号： A61F2/06 , A61L31/082 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： The present invention is generally directed to implantable medical devices for delivering therapeutic agents to the body tissue of a patient and methods for making such medical devices. In particular, the present invention is directed to implantable medical devices, such as intravascular stents, having a surface that includes a plurality of cavities and a plurality of pores and a composition disposed in the pores and/or cavities, as well as, implantable medical devices, such as intravascular stents, having a surface that has a coating composition disposed on the surface, wherein the coating composition includes a plurality of cavities and a plurality of pores and another coating composition disposed in the pores and/or cavities.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置和用于制造这种医疗装置的方法。 特别地，本发明涉及可植入医疗装置，例如血管内支架，其具有包括多个空腔的表面和多个孔以及设置在孔和/或空腔中的组合物，以及植入式医疗 装置，例如血管内支架，其具有设置在表面上的涂层组合物的表面，其中所述涂层组合物包括多个空腔和多个孔以及设置在孔和/或空腔中的另一涂层组合物。
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公开(公告)号：US08182859B2
公开(公告)日：2012-05-22
申请号：US12057135
申请日：2008-03-27
申请人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
发明人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
IPC分类号： A61L33/00
CPC分类号： B05B5/00 , A61F2/91 , A61F2210/009 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/60 , A61L2300/62 , B05C3/09 , B05D1/18 , B05D1/32 , B05D3/207 , B05D2401/32
摘要： The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device. Under some methods, processes, and systems of the invention, particles including a magnetic material and a therapeutic agent may be directed towards a medical device via magnetic attraction. In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.
摘要翻译： 本发明涉及将治疗剂递送到医疗装置的方法，过程和系统。 在一些方法下，本发明的方法和系统，包括磁性材料和治疗剂的颗粒可以通过磁吸引而引向医疗装置。 在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。 在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。
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